State dependency of the effects of microinjection of cholinergic drugs into the nucleus pontis oralis
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State dependency of the effects of microinjection of cholinergic drugs into the nucleus pontis oralis. / López-Rodríguez, F; Kohlmeier, Kristi Anne; Morales, F R; Chase, M H.
In: Brain Research, Vol. 649, No. 1-2, 1994, p. 271-81.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - State dependency of the effects of microinjection of cholinergic drugs into the nucleus pontis oralis
AU - López-Rodríguez, F
AU - Kohlmeier, Kristi Anne
AU - Morales, F R
AU - Chase, M H
PY - 1994
Y1 - 1994
N2 - The microinjection of cholinergic drugs into the pontine reticular formation elicits active sleep-like states that are comprised of the principal physiological patterns of activity that characterize naturally-occurring active sleep, i.e., EEG desynchronization, PGO waves, rapid eye movements and atonia. We have reported that other behavioral states arise even when cholinergic drugs are injected into the exact same reticular location. The present study was conducted to explore the basis for the differences in the drug effect. A combination of acetylcholine and neostigmine was injected by microiontophoresis into the dorsal region of the nucleus pontis oralis in four chronic, unanesthetized cats. The states that were induced by cholinergic drug injection depended on the state of the animal at the time of the injection. When the animal was awake, cholinergic injections resulted in a waking-dissociated state, which was characterized by EEG desynchronization and muscle atonia in a cat that appeared to be awake and was able to track objects in its visual field. If the cat was in quiet sleep at the time of the injection, an active sleep-like state followed that was indistinguishable from naturally-occurring active sleep; on a few occasions following cholinergic injections during quiet sleep there was a quiet sleep-dissociated state, which was characterized by PGO waves and muscle atonia in the cat that by other indices appeared to be in quiet sleep. The results of this study indicate that the state of the animal at the time of drug injection is a critical variable that influences the responses which are induced by cholinergic stimulation of the pontine reticular formation.
AB - The microinjection of cholinergic drugs into the pontine reticular formation elicits active sleep-like states that are comprised of the principal physiological patterns of activity that characterize naturally-occurring active sleep, i.e., EEG desynchronization, PGO waves, rapid eye movements and atonia. We have reported that other behavioral states arise even when cholinergic drugs are injected into the exact same reticular location. The present study was conducted to explore the basis for the differences in the drug effect. A combination of acetylcholine and neostigmine was injected by microiontophoresis into the dorsal region of the nucleus pontis oralis in four chronic, unanesthetized cats. The states that were induced by cholinergic drug injection depended on the state of the animal at the time of the injection. When the animal was awake, cholinergic injections resulted in a waking-dissociated state, which was characterized by EEG desynchronization and muscle atonia in a cat that appeared to be awake and was able to track objects in its visual field. If the cat was in quiet sleep at the time of the injection, an active sleep-like state followed that was indistinguishable from naturally-occurring active sleep; on a few occasions following cholinergic injections during quiet sleep there was a quiet sleep-dissociated state, which was characterized by PGO waves and muscle atonia in the cat that by other indices appeared to be in quiet sleep. The results of this study indicate that the state of the animal at the time of drug injection is a critical variable that influences the responses which are induced by cholinergic stimulation of the pontine reticular formation.
KW - Animals
KW - Behavior, Animal
KW - Cats
KW - Cholinergic Agents
KW - Electroencephalography
KW - Electromyography
KW - Electrooculography
KW - Hippocampus
KW - Iontophoresis
KW - Microinjections
KW - Pons
KW - Reticular Formation
KW - Sleep
KW - Wakefulness
M3 - Journal article
C2 - 7953643
VL - 649
SP - 271
EP - 281
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -
ID: 38346849