Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease. / Navarro, José Fernández; Croteau, Deborah L.; Jurek, Aleksandra; Andrusivova, Zaneta; Yang, Beimeng; Wang, Yue; Ogedegbe, Benjamin; Riaz, Tahira; Støen, Mari; Desler, Claus; Rasmussen, Lene Juel; Tønjum, Tone; Galas, Marie Christine; Lundeberg, Joakim; Bohr, Vilhelm A.
In: iScience, Vol. 23, No. 10, 101556, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease
AU - Navarro, José Fernández
AU - Croteau, Deborah L.
AU - Jurek, Aleksandra
AU - Andrusivova, Zaneta
AU - Yang, Beimeng
AU - Wang, Yue
AU - Ogedegbe, Benjamin
AU - Riaz, Tahira
AU - Støen, Mari
AU - Desler, Claus
AU - Rasmussen, Lene Juel
AU - Tønjum, Tone
AU - Galas, Marie Christine
AU - Lundeberg, Joakim
AU - Bohr, Vilhelm A.
PY - 2020
Y1 - 2020
N2 - Alzheimer disease (AD) is a devastating neurological disease associated with progressive loss of mental skills and cognitive and physical functions whose etiology is not completely understood. Here, our goal was to simultaneously uncover novel and known molecular targets in the structured layers of the hippocampus and olfactory bulbs that may contribute to early hippocampal synaptic deficits and olfactory dysfunction in AD mice. Spatially resolved transcriptomics was used to identify high-confidence genes that were differentially regulated in AD mice relative to controls. A diverse set of genes that modulate stress responses and transcription were predominant in both hippocampi and olfactory bulbs. Notably, we identify Bok, implicated in mitochondrial physiology and cell death, as a spatially downregulated gene in the hippocampus of mouse and human AD brains. In summary, we provide a rich resource of spatially differentially expressed genes, which may contribute to understanding AD pathology.
AB - Alzheimer disease (AD) is a devastating neurological disease associated with progressive loss of mental skills and cognitive and physical functions whose etiology is not completely understood. Here, our goal was to simultaneously uncover novel and known molecular targets in the structured layers of the hippocampus and olfactory bulbs that may contribute to early hippocampal synaptic deficits and olfactory dysfunction in AD mice. Spatially resolved transcriptomics was used to identify high-confidence genes that were differentially regulated in AD mice relative to controls. A diverse set of genes that modulate stress responses and transcription were predominant in both hippocampi and olfactory bulbs. Notably, we identify Bok, implicated in mitochondrial physiology and cell death, as a spatially downregulated gene in the hippocampus of mouse and human AD brains. In summary, we provide a rich resource of spatially differentially expressed genes, which may contribute to understanding AD pathology.
KW - Cellular Neuroscience
KW - Omics
KW - Transcriptomics
U2 - 10.1016/j.isci.2020.101556
DO - 10.1016/j.isci.2020.101556
M3 - Journal article
C2 - 33083725
AN - SCOPUS:85091561842
VL - 23
JO - iScience
JF - iScience
SN - 2589-0042
IS - 10
M1 - 101556
ER -
ID: 249770179