Spatial and temporal patterns of Lyme Neuroborreliosis on Funen, Denmark from 1995-2014
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Spatial and temporal patterns of Lyme Neuroborreliosis on Funen, Denmark from 1995-2014. / Andreasen, Amalie Muus; Dehlendorff, Petter Bart; Knudtzen, Fredrikke Christie; Bødker, Rene; Kjær, Lene Jung; Skarphedinsson, Sigurdur.
In: Scientific Reports, Vol. 10, No. 1, 7796, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Spatial and temporal patterns of Lyme Neuroborreliosis on Funen, Denmark from 1995-2014
AU - Andreasen, Amalie Muus
AU - Dehlendorff, Petter Bart
AU - Knudtzen, Fredrikke Christie
AU - Bødker, Rene
AU - Kjær, Lene Jung
AU - Skarphedinsson, Sigurdur
PY - 2020
Y1 - 2020
N2 - In Europe, Lyme neuroborreliosis (LNB) is the most severe manifestation of Lyme borreliosis and has recently been added to the communicable disease surveillance list for EU/EEA by the European Commission. In Northern Europe, LNB is primarily caused by the spirochete Borrelia garinii and transmitted by the tick Ixodes ricinus. This Danish observational epidemiologic case-control study includes every identified LNB patient (n = 401) on Funen, Denmark, from 1995-2014. We display spatial and temporal LNB incidence variation, seasonal distribution of cases and local spatial case clustering. Seasonal patterns show LNB symptom-onset peaking in July and a significant seasonal difference in number of cases (p < 0.01). We found no significant change in seasonality patterns over time when dividing the study period into 5-year intervals. We identified a significant local geographical hot-spot of cases with a relative risk of 2.44 (p = 0.013). Analysis revealed a significantly shorter distance to nearest forest for cases compared with controls (p < 0.001). We present a novel map of the focal geographical distribution of LNB cases in a high endemic borreliosis area. Continued studies of case clustering in the epidemiology of LNB are of key importance in guiding intervention strategies.
AB - In Europe, Lyme neuroborreliosis (LNB) is the most severe manifestation of Lyme borreliosis and has recently been added to the communicable disease surveillance list for EU/EEA by the European Commission. In Northern Europe, LNB is primarily caused by the spirochete Borrelia garinii and transmitted by the tick Ixodes ricinus. This Danish observational epidemiologic case-control study includes every identified LNB patient (n = 401) on Funen, Denmark, from 1995-2014. We display spatial and temporal LNB incidence variation, seasonal distribution of cases and local spatial case clustering. Seasonal patterns show LNB symptom-onset peaking in July and a significant seasonal difference in number of cases (p < 0.01). We found no significant change in seasonality patterns over time when dividing the study period into 5-year intervals. We identified a significant local geographical hot-spot of cases with a relative risk of 2.44 (p = 0.013). Analysis revealed a significantly shorter distance to nearest forest for cases compared with controls (p < 0.001). We present a novel map of the focal geographical distribution of LNB cases in a high endemic borreliosis area. Continued studies of case clustering in the epidemiology of LNB are of key importance in guiding intervention strategies.
U2 - 10.1038/s41598-020-64638-5
DO - 10.1038/s41598-020-64638-5
M3 - Journal article
C2 - 32385297
VL - 10
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 7796
ER -
ID: 240980777