Small molecules from spiders used as chemical probes
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Small molecules from spiders used as chemical probes. / Olsen, Christian Adam; Kristensen, Anders Skov; Strømgaard, Kristian.
In: Angewandte Chemie International Edition, Vol. 50, No. 48, 25.11.2011, p. 11296-11311.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Small molecules from spiders used as chemical probes
AU - Olsen, Christian Adam
AU - Kristensen, Anders Skov
AU - Strømgaard, Kristian
N1 - Keywords: allemones; pheromones; polyamines; spiders; toxins
PY - 2011/11/25
Y1 - 2011/11/25
N2 - Spiders are important species in ecological systems and as major predators of insects they are endowed with a plethora of low-molecular-weight natural products having intriguing biological activities. The isolation and biological characterization of these entities are well established, however, only very recently have these compounds been used as templates for the design, synthesis, and biological evaluation of synthetic analogues. In contrast, the investigation of compounds responsible for chemical communication between spiders is far less developed, but recently new light has been shed onto the area of pheromones and allomones from spiders. Herein, we recapitulate these recent results, put them into perspective with previous findings, and provide an outlook for future studies of these chemotypes.
AB - Spiders are important species in ecological systems and as major predators of insects they are endowed with a plethora of low-molecular-weight natural products having intriguing biological activities. The isolation and biological characterization of these entities are well established, however, only very recently have these compounds been used as templates for the design, synthesis, and biological evaluation of synthetic analogues. In contrast, the investigation of compounds responsible for chemical communication between spiders is far less developed, but recently new light has been shed onto the area of pheromones and allomones from spiders. Herein, we recapitulate these recent results, put them into perspective with previous findings, and provide an outlook for future studies of these chemotypes.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1002/anie.201101599
DO - 10.1002/anie.201101599
M3 - Review
C2 - 22034051
VL - 50
SP - 11296
EP - 11311
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
SN - 1433-7851
IS - 48
ER -
ID: 35411825