TY - JOUR

T1 - SiPP (Stroke in Pregnancy and Postpartum)

T2 - A prospective, observational, international, multicentre study on pathophysiological mechanisms, clinical profile, management and outcome of cerebrovascular diseases in pregnant and postpartum women

AU - Lorenzano, Svetlana

AU - Kremer, Christine

AU - Pavlovic, Aleksandra

AU - Jovanovic, Dejana R.

AU - Sandset, Else Charlotte

AU - Christensen, Hanne

AU - Bushnell, Cheryl

AU - Arsovska, Anita

AU - Sprigg, Nikola

AU - Roffe, Christine

AU - Ijäs, Petra

AU - Gdovinova, Zuzana

AU - Alexandrov, Anne

AU - Zedde, Marialuisa

AU - Tassi, Rossana

AU - Acciaresi, Monica

AU - Lantz, Maria

AU - Sunnerhagen, Katharina

AU - Zarkov, Marija

AU - Rantanen, Kirsi

AU - Perren, Fabienne

AU - Iversen, Helle K.

AU - Kruuse, Christina

AU - Slowik, Agnieszka

AU - Palazzo, Paola

AU - Korv, Janika

AU - Fromm, Annette

AU - Lovrencic-Huzjan, Arijana

AU - Korompoki, Eleni

AU - Fonseca, Ana Catarina

AU - Gall, Seana L.

AU - Brunner, Freimuth

AU - Caso, Valeria

AU - Sacco, Simona

AU - for the SiPP Trial Investigators and ESO-WISE Group

PY - 2020

Y1 - 2020

N2 - Rationale: Cerebrovascular diseases associated with pregnancy and postpartum period are uncommon; however, they can have an important impact on health of both women and foetus or newborn. Aims: To evaluate the frequency, characteristics and management of cerebrovascular events in pregnant/postpartum women, to clarify pathophysiological mechanisms underlying the occurrence of these events including biomolecular aspects, and to assess the short- and long-term cerebrovascular and global cardiovascular outcome of these patients, their predictors and infant outcome. Methods and design: This is an observational, prospective, multicentre, international case–control study. The study will include patients with cerebrovascular events during pregnancy and/or within six months after delivery. For each included case, two controls will be prospectively recruited: one pregnant or puerperal subject without any history of cerebrovascular event and one non-pregnant or non-puerperal subject with a recent cerebrovascular event. All controls will be matched by age, ethnicity and type of cerebrovascular event with their assigned cases. The pregnant controls will be matched also by pregnancy weeks/trimester. Follow-up will last 24 months for the mother and 12 months for the infant. Summary: To better understand causes and outcomes of uncommon conditions like pregnancy/postpartum-related cerebrovascular events, the development of multisite, multidisciplinary registry-based studies, such as the Stroke in Pregnancy and Postpartum study, is needed in order to collect an adequate number of patients, draw reliable conclusions and give definite recommendations on their management.

AB - Rationale: Cerebrovascular diseases associated with pregnancy and postpartum period are uncommon; however, they can have an important impact on health of both women and foetus or newborn. Aims: To evaluate the frequency, characteristics and management of cerebrovascular events in pregnant/postpartum women, to clarify pathophysiological mechanisms underlying the occurrence of these events including biomolecular aspects, and to assess the short- and long-term cerebrovascular and global cardiovascular outcome of these patients, their predictors and infant outcome. Methods and design: This is an observational, prospective, multicentre, international case–control study. The study will include patients with cerebrovascular events during pregnancy and/or within six months after delivery. For each included case, two controls will be prospectively recruited: one pregnant or puerperal subject without any history of cerebrovascular event and one non-pregnant or non-puerperal subject with a recent cerebrovascular event. All controls will be matched by age, ethnicity and type of cerebrovascular event with their assigned cases. The pregnant controls will be matched also by pregnancy weeks/trimester. Follow-up will last 24 months for the mother and 12 months for the infant. Summary: To better understand causes and outcomes of uncommon conditions like pregnancy/postpartum-related cerebrovascular events, the development of multisite, multidisciplinary registry-based studies, such as the Stroke in Pregnancy and Postpartum study, is needed in order to collect an adequate number of patients, draw reliable conclusions and give definite recommendations on their management.

KW - cerebrovascular disease

KW - outcome

KW - postpartum

KW - pregnancy

KW - puerperium

KW - Stroke

U2 - 10.1177/2396987319893512

DO - 10.1177/2396987319893512

M3 - Journal article

C2 - 32637653

AN - SCOPUS:85077375173

VL - 5

SP - 193

EP - 203

JO - European Stroke Journal

JF - European Stroke Journal

SN - 2396-9873

IS - 2

ER -