Single particles as resonators for thermomechanical analysis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Single particles as resonators for thermomechanical analysis. / Okeyo, Peter Ouma; Larsen, Peter Emil; Kissi, Eric Ofosu; Ajalloueian, Fatemeh; Rades, Thomas; Rantanen, Jukka; Boisen, Anja.

In: Nature Communications, Vol. 11, No. 1, 1235, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Okeyo, PO, Larsen, PE, Kissi, EO, Ajalloueian, F, Rades, T, Rantanen, J & Boisen, A 2020, 'Single particles as resonators for thermomechanical analysis', Nature Communications, vol. 11, no. 1, 1235. https://doi.org/10.1038/s41467-020-15028-y

APA

Okeyo, P. O., Larsen, P. E., Kissi, E. O., Ajalloueian, F., Rades, T., Rantanen, J., & Boisen, A. (2020). Single particles as resonators for thermomechanical analysis. Nature Communications, 11(1), [1235]. https://doi.org/10.1038/s41467-020-15028-y

Vancouver

Okeyo PO, Larsen PE, Kissi EO, Ajalloueian F, Rades T, Rantanen J et al. Single particles as resonators for thermomechanical analysis. Nature Communications. 2020;11(1). 1235. https://doi.org/10.1038/s41467-020-15028-y

Author

Okeyo, Peter Ouma ; Larsen, Peter Emil ; Kissi, Eric Ofosu ; Ajalloueian, Fatemeh ; Rades, Thomas ; Rantanen, Jukka ; Boisen, Anja. / Single particles as resonators for thermomechanical analysis. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Bibtex

@article{aec4887f8c8941fa9e971dadfc17bbf6,

title = "Single particles as resonators for thermomechanical analysis",

abstract = "Thermal methods are indispensable for the characterization of most materials. However, the existing methods require bulk amounts for analysis and give an averaged response of a material. This can be especially challenging in a biomedical setting, where only very limited amounts of material are initially available. Nano- and microelectromechanical systems (NEMS/MEMS) offer the possibility of conducting thermal analysis on small amounts of materials in the nano-microgram range, but cleanroom fabricated resonators are required. Here, we report the use of single drug and collagen particles as micro mechanical resonators, thereby eliminating the need for cleanroom fabrication. Furthermore, the proposed method reveals additional thermal transitions that are undetected by standard thermal methods and provide the possibility of understanding fundamental changes in the mechanical properties of the materials during thermal cycling. This method is applicable to a variety of different materials and opens the door to fundamental mechanistic insights.",

keywords = "DIFFERENTIAL SCANNING CALORIMETRY, THERMAL-ANALYSIS, MECHANICAL-PROPERTIES, THEOPHYLLINE MONOHYDRATE, INFRARED-SPECTROSCOPY, POLYMORPHIC IMPURITY, STRING RESONATORS, COLLAGEN, DEHYDRATION, TRANSFORMATION",

author = "Okeyo, {Peter Ouma} and Larsen, {Peter Emil} and Kissi, {Eric Ofosu} and Fatemeh Ajalloueian and Thomas Rades and Jukka Rantanen and Anja Boisen",

year = "2020",

doi = "10.1038/s41467-020-15028-y",

language = "English",

volume = "11",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - Single particles as resonators for thermomechanical analysis

AU - Okeyo, Peter Ouma

AU - Larsen, Peter Emil

AU - Kissi, Eric Ofosu

AU - Ajalloueian, Fatemeh

AU - Rades, Thomas

AU - Rantanen, Jukka

AU - Boisen, Anja

PY - 2020

Y1 - 2020

N2 - Thermal methods are indispensable for the characterization of most materials. However, the existing methods require bulk amounts for analysis and give an averaged response of a material. This can be especially challenging in a biomedical setting, where only very limited amounts of material are initially available. Nano- and microelectromechanical systems (NEMS/MEMS) offer the possibility of conducting thermal analysis on small amounts of materials in the nano-microgram range, but cleanroom fabricated resonators are required. Here, we report the use of single drug and collagen particles as micro mechanical resonators, thereby eliminating the need for cleanroom fabrication. Furthermore, the proposed method reveals additional thermal transitions that are undetected by standard thermal methods and provide the possibility of understanding fundamental changes in the mechanical properties of the materials during thermal cycling. This method is applicable to a variety of different materials and opens the door to fundamental mechanistic insights.

AB - Thermal methods are indispensable for the characterization of most materials. However, the existing methods require bulk amounts for analysis and give an averaged response of a material. This can be especially challenging in a biomedical setting, where only very limited amounts of material are initially available. Nano- and microelectromechanical systems (NEMS/MEMS) offer the possibility of conducting thermal analysis on small amounts of materials in the nano-microgram range, but cleanroom fabricated resonators are required. Here, we report the use of single drug and collagen particles as micro mechanical resonators, thereby eliminating the need for cleanroom fabrication. Furthermore, the proposed method reveals additional thermal transitions that are undetected by standard thermal methods and provide the possibility of understanding fundamental changes in the mechanical properties of the materials during thermal cycling. This method is applicable to a variety of different materials and opens the door to fundamental mechanistic insights.

KW - DIFFERENTIAL SCANNING CALORIMETRY

KW - THERMAL-ANALYSIS

KW - MECHANICAL-PROPERTIES

KW - THEOPHYLLINE MONOHYDRATE

KW - INFRARED-SPECTROSCOPY

KW - POLYMORPHIC IMPURITY

KW - STRING RESONATORS

KW - COLLAGEN

KW - DEHYDRATION

KW - TRANSFORMATION

U2 - 10.1038/s41467-020-15028-y

DO - 10.1038/s41467-020-15028-y

M3 - Journal article

C2 - 32144254

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 1235

ER -

ID: 248192553