Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets

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Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets. / Jensen, Michael Ladegaard; Sangild, Per Torp; Lykke, Mikkel; Schmidt, Mette; Boye, Mette; Jensen, Bent B; Thymann, Thomas.

In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 305, No. 1, 2013, p. R4-R12.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Jensen, ML, Sangild, PT, Lykke, M, Schmidt, M, Boye, M, Jensen, BB & Thymann, T 2013, 'Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 305, no. 1, pp. R4-R12. https://doi.org/10.1152/ajpregu.00094.2013

APA

Jensen, M. L., Sangild, P. T., Lykke, M., Schmidt, M., Boye, M., Jensen, B. B., & Thymann, T. (2013). Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 305(1), R4-R12. https://doi.org/10.1152/ajpregu.00094.2013

Vancouver

Jensen ML, Sangild PT, Lykke M, Schmidt M, Boye M, Jensen BB et al. Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2013;305(1):R4-R12. https://doi.org/10.1152/ajpregu.00094.2013

Author

Jensen, Michael Ladegaard ; Sangild, Per Torp ; Lykke, Mikkel ; Schmidt, Mette ; Boye, Mette ; Jensen, Bent B ; Thymann, Thomas. / Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets. In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 2013 ; Vol. 305, No. 1. pp. R4-R12.

Bibtex

@article{6f64f191924f4ecf8da9dd1e9cec0b06,
title = "Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets",
abstract = "Preterm birth and formula feeding predispose to necrotizing enterocolitis (NEC) in infants. As mother's milk is often absent following preterm delivery, infant formula (IF) and human donor milk (HM) are frequently used as alternatives. We have previously shown that porcine and bovine colostrum (BC) provide similar NEC protection in preterm piglets relative to IF. We hypothesized that HM exerts similar effects and that this effect is partly species-independent. Preterm piglets (n = 40) received 2 days of total parenteral nutrition, followed by a rapid transition to full enteral feeding (15 ml·kg(-1)·2 h(-1)) for 2 days using BC (n = 13), HM (n = 13), or IF (n = 14). Intestinal passage time and hexose absorption were tested in vivo. Body and organ weights were recorded on day 5, and macroscopic NEC lesions in the gastrointestinal tract were assessed. Intestinal samples were collected for determination of histomorphology, histopathology, tissue IL-6 and IL-8, organic acids, bacterial adherence by fluorescence in situ hybridization score, and digestive enzyme activities. Relative to IF, pigs from BC and HM showed longer intestinal passage time; higher weight gain, hexose absorptive capacity, mucosal proportion, and enzyme activities; lower NEC incidence, organic acid concentration, and IL-8 concentration; and reduced histopathology lesions. Tissue IL-6 concentration and bacterial adherence score were lower for HM, relative to both BC and IF groups. We conclude that BC and HM are both superior to IF in stimulating gut structure, function, and NEC resistance in preterm piglets. BC may be a relevant alternative to HM when mother's milk is unavailable during the first week after preterm birth.",
author = "Jensen, {Michael Ladegaard} and Sangild, {Per Torp} and Mikkel Lykke and Mette Schmidt and Mette Boye and Jensen, {Bent B} and Thomas Thymann",
note = "CURIS 2013 NEXS 188",
year = "2013",
doi = "10.1152/ajpregu.00094.2013",
language = "English",
volume = "305",
pages = "R4--R12",
journal = "American Journal of Physiology: Regulatory, Integrative and Comparative Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Similar efficacy of human banked milk and bovine colostrum to decrease incidence of necrotizing enterocolitis in preterm piglets

AU - Jensen, Michael Ladegaard

AU - Sangild, Per Torp

AU - Lykke, Mikkel

AU - Schmidt, Mette

AU - Boye, Mette

AU - Jensen, Bent B

AU - Thymann, Thomas

N1 - CURIS 2013 NEXS 188

PY - 2013

Y1 - 2013

N2 - Preterm birth and formula feeding predispose to necrotizing enterocolitis (NEC) in infants. As mother's milk is often absent following preterm delivery, infant formula (IF) and human donor milk (HM) are frequently used as alternatives. We have previously shown that porcine and bovine colostrum (BC) provide similar NEC protection in preterm piglets relative to IF. We hypothesized that HM exerts similar effects and that this effect is partly species-independent. Preterm piglets (n = 40) received 2 days of total parenteral nutrition, followed by a rapid transition to full enteral feeding (15 ml·kg(-1)·2 h(-1)) for 2 days using BC (n = 13), HM (n = 13), or IF (n = 14). Intestinal passage time and hexose absorption were tested in vivo. Body and organ weights were recorded on day 5, and macroscopic NEC lesions in the gastrointestinal tract were assessed. Intestinal samples were collected for determination of histomorphology, histopathology, tissue IL-6 and IL-8, organic acids, bacterial adherence by fluorescence in situ hybridization score, and digestive enzyme activities. Relative to IF, pigs from BC and HM showed longer intestinal passage time; higher weight gain, hexose absorptive capacity, mucosal proportion, and enzyme activities; lower NEC incidence, organic acid concentration, and IL-8 concentration; and reduced histopathology lesions. Tissue IL-6 concentration and bacterial adherence score were lower for HM, relative to both BC and IF groups. We conclude that BC and HM are both superior to IF in stimulating gut structure, function, and NEC resistance in preterm piglets. BC may be a relevant alternative to HM when mother's milk is unavailable during the first week after preterm birth.

AB - Preterm birth and formula feeding predispose to necrotizing enterocolitis (NEC) in infants. As mother's milk is often absent following preterm delivery, infant formula (IF) and human donor milk (HM) are frequently used as alternatives. We have previously shown that porcine and bovine colostrum (BC) provide similar NEC protection in preterm piglets relative to IF. We hypothesized that HM exerts similar effects and that this effect is partly species-independent. Preterm piglets (n = 40) received 2 days of total parenteral nutrition, followed by a rapid transition to full enteral feeding (15 ml·kg(-1)·2 h(-1)) for 2 days using BC (n = 13), HM (n = 13), or IF (n = 14). Intestinal passage time and hexose absorption were tested in vivo. Body and organ weights were recorded on day 5, and macroscopic NEC lesions in the gastrointestinal tract were assessed. Intestinal samples were collected for determination of histomorphology, histopathology, tissue IL-6 and IL-8, organic acids, bacterial adherence by fluorescence in situ hybridization score, and digestive enzyme activities. Relative to IF, pigs from BC and HM showed longer intestinal passage time; higher weight gain, hexose absorptive capacity, mucosal proportion, and enzyme activities; lower NEC incidence, organic acid concentration, and IL-8 concentration; and reduced histopathology lesions. Tissue IL-6 concentration and bacterial adherence score were lower for HM, relative to both BC and IF groups. We conclude that BC and HM are both superior to IF in stimulating gut structure, function, and NEC resistance in preterm piglets. BC may be a relevant alternative to HM when mother's milk is unavailable during the first week after preterm birth.

U2 - 10.1152/ajpregu.00094.2013

DO - 10.1152/ajpregu.00094.2013

M3 - Journal article

C2 - 23657639

VL - 305

SP - R4-R12

JO - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

JF - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

SN - 0363-6119

IS - 1

ER -

ID: 49702868