Short-term betaadrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients
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Short-term betaadrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients. / Perrild, H.; Feldt-Rasmussen, U.; Kayser, L.; Hansen, J. Mølholm.
In: Journal of Endocrinological Investigation, Vol. 9, No. 5, 1986, p. 413-415.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Short-term betaadrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients
AU - Perrild, H.
AU - Feldt-Rasmussen, U.
AU - Kayser, L.
AU - Hansen, J. Mølholm
PY - 1986
Y1 - 1986
N2 - Cardioselective [Acebutolol (N = 10)] or noncardioselective [Oxprenolol (N = 9)] or [Pindolol (N = 9)] beta-adrenergic blockers were given to patients with suspected hyperthyroidism. Four h after start of the betablockade median serum thyroglobulin (Tg) had decreased to 33 (range: 13–325) μg/l from 41 (range: 12–333) μg/l before start in the acebutolol treated group (p < 0.05). A significant decrease in serum Tg was also found in the oxprenolol-treated group [before start: 45 (24–423) μg/l and after 4 h: 43 (18–363) μg/l (p < 0.01)] and in the pindolol-treated group [before start: 154 (33–210) μg/l and after 4 h: 63 (19–157) μg/l (p<0.05) treated groups. After 7 days treatment the decrease in serum Tg was significant [to 85 (34–182) μg/l (p< 0.02)] only in the Pindolol-treated group. It is suggested that both hemodynamic changes as well as interference with the intrathyroidal 12 S Tg to 19 S Tg dimerization might explain the changes in serum Tg during betablockade. Knowledge of drug influence on serum thyroglobulin is important for the interpretation of variations found in patients where thyroglobulin is being used for diagnostic purposes.
AB - Cardioselective [Acebutolol (N = 10)] or noncardioselective [Oxprenolol (N = 9)] or [Pindolol (N = 9)] beta-adrenergic blockers were given to patients with suspected hyperthyroidism. Four h after start of the betablockade median serum thyroglobulin (Tg) had decreased to 33 (range: 13–325) μg/l from 41 (range: 12–333) μg/l before start in the acebutolol treated group (p < 0.05). A significant decrease in serum Tg was also found in the oxprenolol-treated group [before start: 45 (24–423) μg/l and after 4 h: 43 (18–363) μg/l (p < 0.01)] and in the pindolol-treated group [before start: 154 (33–210) μg/l and after 4 h: 63 (19–157) μg/l (p<0.05) treated groups. After 7 days treatment the decrease in serum Tg was significant [to 85 (34–182) μg/l (p< 0.02)] only in the Pindolol-treated group. It is suggested that both hemodynamic changes as well as interference with the intrathyroidal 12 S Tg to 19 S Tg dimerization might explain the changes in serum Tg during betablockade. Knowledge of drug influence on serum thyroglobulin is important for the interpretation of variations found in patients where thyroglobulin is being used for diagnostic purposes.
KW - Cardioselective
KW - hyperthyroidism
KW - noncardioselective betablockers
KW - thyroglobulin
U2 - 10.1007/BF03346953
DO - 10.1007/BF03346953
M3 - Journal article
C2 - 2878948
AN - SCOPUS:0022928747
VL - 9
SP - 413
EP - 415
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 5
ER -
ID: 335677200