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Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. / Kote-Jarai, Zsofia; Olama, Ali Amin Al; Giles, Graham G; Severi, Gianluca; Schleutker, Johanna; Weischer, Maren; Campa, Daniele; Riboli, Elio; Key, Tim; Gronberg, Henrik; Hunter, David J; Kraft, Peter; Thun, Michael J; Ingles, Sue; Chanock, Stephen; Albanes, Demetrius; Hayes, Richard B; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Pharoah, Paul; Schumacher, Fredrick; Henderson, Brian E; Stanford, Janet L; Ostrander, Elaine A; Sorensen, Karina Dalsgaard; Dörk, Thilo; Andriole, Gerald; Dickinson, Joanne L; Cybulski, Cezary; Lubinski, Jan; Spurdle, Amanda; Clements, Judith A; Chambers, Suzanne; Aitken, Joanne; Gardiner, R A Frank; Thibodeau, Stephen N; Schaid, Dan; John, Esther M; Maier, Christiane; Vogel, Walther; Cooney, Kathleen A; Park, Sung Jong; Cannon-Albright, Lisa; Brenner, Hermann; Klarskov, Ole Peter; Nordestgaard, Børge G; Røder, Andreas; Tybjærg-Hansen, Anne; Bojesen, Stig E; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology.
In:
Nature Genetics, Vol. 43, No. 8, 2011, p. 785-91.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Kote-Jarai, Z, Olama, AAA, Giles, GG, Severi, G, Schleutker, J, Weischer, M, Campa, D, Riboli, E, Key, T, Gronberg, H, Hunter, DJ, Kraft, P, Thun, MJ, Ingles, S, Chanock, S, Albanes, D, Hayes, RB, Neal, DE, Hamdy, FC, Donovan, JL, Pharoah, P, Schumacher, F, Henderson, BE, Stanford, JL, Ostrander, EA, Sorensen, KD, Dörk, T, Andriole, G, Dickinson, JL, Cybulski, C, Lubinski, J, Spurdle, A, Clements, JA, Chambers, S, Aitken, J, Gardiner, RAF, Thibodeau, SN, Schaid, D, John, EM, Maier, C, Vogel, W, Cooney, KA, Park, SJ, Cannon-Albright, L, Brenner, H, Klarskov, OP
, Nordestgaard, BG, Røder, A
, Tybjærg-Hansen, A, Bojesen, SE & UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology 2011, '
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study',
Nature Genetics, vol. 43, no. 8, pp. 785-91.
https://doi.org/10.1038/ng.882APA
Kote-Jarai, Z., Olama, A. A. A., Giles, G. G., Severi, G., Schleutker, J., Weischer, M., Campa, D., Riboli, E., Key, T., Gronberg, H., Hunter, D. J., Kraft, P., Thun, M. J., Ingles, S., Chanock, S., Albanes, D., Hayes, R. B., Neal, D. E., Hamdy, F. C., ... UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology (2011).
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Nature Genetics,
43(8), 785-91.
https://doi.org/10.1038/ng.882Vancouver
Kote-Jarai Z, Olama AAA, Giles GG, Severi G, Schleutker J, Weischer M et al.
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Nature Genetics. 2011;43(8):785-91.
https://doi.org/10.1038/ng.882Author
Kote-Jarai, Zsofia ; Olama, Ali Amin Al ; Giles, Graham G ; Severi, Gianluca ; Schleutker, Johanna ; Weischer, Maren ; Campa, Daniele ; Riboli, Elio ; Key, Tim ; Gronberg, Henrik ; Hunter, David J ; Kraft, Peter ; Thun, Michael J ; Ingles, Sue ; Chanock, Stephen ; Albanes, Demetrius ; Hayes, Richard B ; Neal, David E ; Hamdy, Freddie C ; Donovan, Jenny L ; Pharoah, Paul ; Schumacher, Fredrick ; Henderson, Brian E ; Stanford, Janet L ; Ostrander, Elaine A ; Sorensen, Karina Dalsgaard ; Dörk, Thilo ; Andriole, Gerald ; Dickinson, Joanne L ; Cybulski, Cezary ; Lubinski, Jan ; Spurdle, Amanda ; Clements, Judith A ; Chambers, Suzanne ; Aitken, Joanne ; Gardiner, R A Frank ; Thibodeau, Stephen N ; Schaid, Dan ; John, Esther M ; Maier, Christiane ; Vogel, Walther ; Cooney, Kathleen A ; Park, Sung Jong ; Cannon-Albright, Lisa ; Brenner, Hermann ; Klarskov, Ole Peter ; Nordestgaard, Børge G ; Røder, Andreas ; Tybjærg-Hansen, Anne ; Bojesen, Stig E ; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology. / Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. In: Nature Genetics. 2011 ; Vol. 43, No. 8. pp. 785-91.
Bibtex
@article{2e6de3dabfcf407ab6d5db23af5d1059,
title = "Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study",
abstract = "Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.",
author = "Zsofia Kote-Jarai and Olama, {Ali Amin Al} and Giles, {Graham G} and Gianluca Severi and Johanna Schleutker and Maren Weischer and Daniele Campa and Elio Riboli and Tim Key and Henrik Gronberg and Hunter, {David J} and Peter Kraft and Thun, {Michael J} and Sue Ingles and Stephen Chanock and Demetrius Albanes and Hayes, {Richard B} and Neal, {David E} and Hamdy, {Freddie C} and Donovan, {Jenny L} and Paul Pharoah and Fredrick Schumacher and Henderson, {Brian E} and Stanford, {Janet L} and Ostrander, {Elaine A} and Sorensen, {Karina Dalsgaard} and Thilo D{\"o}rk and Gerald Andriole and Dickinson, {Joanne L} and Cezary Cybulski and Jan Lubinski and Amanda Spurdle and Clements, {Judith A} and Suzanne Chambers and Joanne Aitken and Gardiner, {R A Frank} and Thibodeau, {Stephen N} and Dan Schaid and John, {Esther M} and Christiane Maier and Walther Vogel and Cooney, {Kathleen A} and Park, {Sung Jong} and Lisa Cannon-Albright and Hermann Brenner and Klarskov, {Ole Peter} and Nordestgaard, {B{\o}rge G} and Andreas R{\o}der and Anne Tybj{\ae}rg-Hansen and Bojesen, {Stig E} and Anne Tybj{\ae}rg-Hansen",
year = "2011",
doi = "http://dx.doi.org/10.1038/ng.882",
language = "English",
volume = "43",
pages = "785--91",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "8",
}
RIS
TY - JOUR
T1 - Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
AU - Kote-Jarai, Zsofia
AU - Olama, Ali Amin Al
AU - Giles, Graham G
AU - Severi, Gianluca
AU - Schleutker, Johanna
AU - Weischer, Maren
AU - Campa, Daniele
AU - Riboli, Elio
AU - Key, Tim
AU - Gronberg, Henrik
AU - Hunter, David J
AU - Kraft, Peter
AU - Thun, Michael J
AU - Ingles, Sue
AU - Chanock, Stephen
AU - Albanes, Demetrius
AU - Hayes, Richard B
AU - Neal, David E
AU - Hamdy, Freddie C
AU - Donovan, Jenny L
AU - Pharoah, Paul
AU - Schumacher, Fredrick
AU - Henderson, Brian E
AU - Stanford, Janet L
AU - Ostrander, Elaine A
AU - Sorensen, Karina Dalsgaard
AU - Dörk, Thilo
AU - Andriole, Gerald
AU - Dickinson, Joanne L
AU - Cybulski, Cezary
AU - Lubinski, Jan
AU - Spurdle, Amanda
AU - Clements, Judith A
AU - Chambers, Suzanne
AU - Aitken, Joanne
AU - Gardiner, R A Frank
AU - Thibodeau, Stephen N
AU - Schaid, Dan
AU - John, Esther M
AU - Maier, Christiane
AU - Vogel, Walther
AU - Cooney, Kathleen A
AU - Park, Sung Jong
AU - Cannon-Albright, Lisa
AU - Brenner, Hermann
AU - Klarskov, Ole Peter
AU - Nordestgaard, Børge G
AU - Røder, Andreas
AU - Tybjærg-Hansen, Anne
AU - Bojesen, Stig E
AU - UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology
PY - 2011
Y1 - 2011
N2 - Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.
AB - Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.
U2 - http://dx.doi.org/10.1038/ng.882
DO - http://dx.doi.org/10.1038/ng.882
M3 - Journal article
VL - 43
SP - 785
EP - 791
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 8
ER -
