Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

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Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. / Kote-Jarai, Zsofia; Olama, Ali Amin Al; Giles, Graham G; Severi, Gianluca; Schleutker, Johanna; Weischer, Maren; Campa, Daniele; Riboli, Elio; Key, Tim; Gronberg, Henrik; Hunter, David J; Kraft, Peter; Thun, Michael J; Ingles, Sue; Chanock, Stephen; Albanes, Demetrius; Hayes, Richard B; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Pharoah, Paul; Schumacher, Fredrick; Henderson, Brian E; Stanford, Janet L; Ostrander, Elaine A; Sorensen, Karina Dalsgaard; Dörk, Thilo; Andriole, Gerald; Dickinson, Joanne L; Cybulski, Cezary; Lubinski, Jan; Spurdle, Amanda; Clements, Judith A; Chambers, Suzanne; Aitken, Joanne; Gardiner, R A Frank; Thibodeau, Stephen N; Schaid, Dan; John, Esther M; Maier, Christiane; Vogel, Walther; Cooney, Kathleen A; Park, Sung Jong; Cannon-Albright, Lisa; Brenner, Hermann; Klarskov, Ole Peter; Nordestgaard, Børge G; Røder, Andreas; Tybjærg-Hansen, Anne; Bojesen, Stig E; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology.

In: Nature Genetics, Vol. 43, No. 8, 2011, p. 785-91.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kote-Jarai, Z, Olama, AAA, Giles, GG, Severi, G, Schleutker, J, Weischer, M, Campa, D, Riboli, E, Key, T, Gronberg, H, Hunter, DJ, Kraft, P, Thun, MJ, Ingles, S, Chanock, S, Albanes, D, Hayes, RB, Neal, DE, Hamdy, FC, Donovan, JL, Pharoah, P, Schumacher, F, Henderson, BE, Stanford, JL, Ostrander, EA, Sorensen, KD, Dörk, T, Andriole, G, Dickinson, JL, Cybulski, C, Lubinski, J, Spurdle, A, Clements, JA, Chambers, S, Aitken, J, Gardiner, RAF, Thibodeau, SN, Schaid, D, John, EM, Maier, C, Vogel, W, Cooney, KA, Park, SJ, Cannon-Albright, L, Brenner, H, Klarskov, OP, Nordestgaard, BG, Røder, A, Tybjærg-Hansen, A, Bojesen, SE & UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology 2011, 'Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study', Nature Genetics, vol. 43, no. 8, pp. 785-91. https://doi.org/10.1038/ng.882

APA

Kote-Jarai, Z., Olama, A. A. A., Giles, G. G., Severi, G., Schleutker, J., Weischer, M., ... UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology (2011). Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nature Genetics, 43(8), 785-91. https://doi.org/10.1038/ng.882

Vancouver

Kote-Jarai Z, Olama AAA, Giles GG, Severi G, Schleutker J, Weischer M et al. Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nature Genetics. 2011;43(8):785-91. https://doi.org/10.1038/ng.882

Author

Kote-Jarai, Zsofia ; Olama, Ali Amin Al ; Giles, Graham G ; Severi, Gianluca ; Schleutker, Johanna ; Weischer, Maren ; Campa, Daniele ; Riboli, Elio ; Key, Tim ; Gronberg, Henrik ; Hunter, David J ; Kraft, Peter ; Thun, Michael J ; Ingles, Sue ; Chanock, Stephen ; Albanes, Demetrius ; Hayes, Richard B ; Neal, David E ; Hamdy, Freddie C ; Donovan, Jenny L ; Pharoah, Paul ; Schumacher, Fredrick ; Henderson, Brian E ; Stanford, Janet L ; Ostrander, Elaine A ; Sorensen, Karina Dalsgaard ; Dörk, Thilo ; Andriole, Gerald ; Dickinson, Joanne L ; Cybulski, Cezary ; Lubinski, Jan ; Spurdle, Amanda ; Clements, Judith A ; Chambers, Suzanne ; Aitken, Joanne ; Gardiner, R A Frank ; Thibodeau, Stephen N ; Schaid, Dan ; John, Esther M ; Maier, Christiane ; Vogel, Walther ; Cooney, Kathleen A ; Park, Sung Jong ; Cannon-Albright, Lisa ; Brenner, Hermann ; Klarskov, Ole Peter ; Nordestgaard, Børge G ; Røder, Andreas ; Tybjærg-Hansen, Anne ; Bojesen, Stig E ; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology. / Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. In: Nature Genetics. 2011 ; Vol. 43, No. 8. pp. 785-91.

Bibtex

@article{2e6de3dabfcf407ab6d5db23af5d1059,
title = "Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study",
abstract = "Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25{\%} of the familial risk in this disease, have now been identified.",
author = "Zsofia Kote-Jarai and Olama, {Ali Amin Al} and Giles, {Graham G} and Gianluca Severi and Johanna Schleutker and Maren Weischer and Daniele Campa and Elio Riboli and Tim Key and Henrik Gronberg and Hunter, {David J} and Peter Kraft and Thun, {Michael J} and Sue Ingles and Stephen Chanock and Demetrius Albanes and Hayes, {Richard B} and Neal, {David E} and Hamdy, {Freddie C} and Donovan, {Jenny L} and Paul Pharoah and Fredrick Schumacher and Henderson, {Brian E} and Stanford, {Janet L} and Ostrander, {Elaine A} and Sorensen, {Karina Dalsgaard} and Thilo D{\"o}rk and Gerald Andriole and Dickinson, {Joanne L} and Cezary Cybulski and Jan Lubinski and Amanda Spurdle and Clements, {Judith A} and Suzanne Chambers and Joanne Aitken and Gardiner, {R A Frank} and Thibodeau, {Stephen N} and Dan Schaid and John, {Esther M} and Christiane Maier and Walther Vogel and Cooney, {Kathleen A} and Park, {Sung Jong} and Lisa Cannon-Albright and Hermann Brenner and Klarskov, {Ole Peter} and Nordestgaard, {B{\o}rge G} and Andreas R{\o}der and Anne Tybj{\ae}rg-Hansen and Bojesen, {Stig E} and Anne Tybj{\ae}rg-Hansen",
year = "2011",
doi = "http://dx.doi.org/10.1038/ng.882",
language = "English",
volume = "43",
pages = "785--91",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "8",

}

RIS

TY - JOUR

T1 - Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study

AU - Kote-Jarai, Zsofia

AU - Olama, Ali Amin Al

AU - Giles, Graham G

AU - Severi, Gianluca

AU - Schleutker, Johanna

AU - Weischer, Maren

AU - Campa, Daniele

AU - Riboli, Elio

AU - Key, Tim

AU - Gronberg, Henrik

AU - Hunter, David J

AU - Kraft, Peter

AU - Thun, Michael J

AU - Ingles, Sue

AU - Chanock, Stephen

AU - Albanes, Demetrius

AU - Hayes, Richard B

AU - Neal, David E

AU - Hamdy, Freddie C

AU - Donovan, Jenny L

AU - Pharoah, Paul

AU - Schumacher, Fredrick

AU - Henderson, Brian E

AU - Stanford, Janet L

AU - Ostrander, Elaine A

AU - Sorensen, Karina Dalsgaard

AU - Dörk, Thilo

AU - Andriole, Gerald

AU - Dickinson, Joanne L

AU - Cybulski, Cezary

AU - Lubinski, Jan

AU - Spurdle, Amanda

AU - Clements, Judith A

AU - Chambers, Suzanne

AU - Aitken, Joanne

AU - Gardiner, R A Frank

AU - Thibodeau, Stephen N

AU - Schaid, Dan

AU - John, Esther M

AU - Maier, Christiane

AU - Vogel, Walther

AU - Cooney, Kathleen A

AU - Park, Sung Jong

AU - Cannon-Albright, Lisa

AU - Brenner, Hermann

AU - Klarskov, Ole Peter

AU - Nordestgaard, Børge G

AU - Røder, Andreas

AU - Tybjærg-Hansen, Anne

AU - Bojesen, Stig E

AU - UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology

PY - 2011

Y1 - 2011

N2 - Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.

AB - Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.

U2 - http://dx.doi.org/10.1038/ng.882

DO - http://dx.doi.org/10.1038/ng.882

M3 - Journal article

VL - 43

SP - 785

EP - 791

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 8

ER -

ID: 40184636