Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4. / Gutheil, H.; Nielsen, O. H.; Hansen, T. M.; Thomsen, B. S.; Ahnfelt-Rønne, I.

In: Inflammation Research, Vol. 45, No. 1, 05.02.1996, p. 31-34.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gutheil, H, Nielsen, OH, Hansen, TM, Thomsen, BS & Ahnfelt-Rønne, I 1996, 'Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4', Inflammation Research, vol. 45, no. 1, pp. 31-34. https://doi.org/10.1007/BF02263502

APA

Gutheil, H., Nielsen, O. H., Hansen, T. M., Thomsen, B. S., & Ahnfelt-Rønne, I. (1996). Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4. Inflammation Research, 45(1), 31-34. https://doi.org/10.1007/BF02263502

Vancouver

Gutheil H, Nielsen OH, Hansen TM, Thomsen BS, Ahnfelt-Rønne I. Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4. Inflammation Research. 1996 Feb 5;45(1):31-34. https://doi.org/10.1007/BF02263502

Author

Gutheil, H. ; Nielsen, O. H. ; Hansen, T. M. ; Thomsen, B. S. ; Ahnfelt-Rønne, I. / Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4. In: Inflammation Research. 1996 ; Vol. 45, No. 1. pp. 31-34.

Bibtex

@article{91caa850ae8c4ddf959fa5aeee26b630,
title = "Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4",
abstract = "The synthesis of leukotriene B4 by A23187-stimulated rat peritoneal leukocytes was studied in the presence of 0.1% normal human serum, serum from patients treated with NSAIDs for either an inflammatory (rheumatoid arthritis, RA) or a non-inflammatory condition (lumbar disc protrusion, LDP), and serum from RA patients drawn one week after withdrawal from NSAID treatment. The capacity for LTB4 synthesis was significantly lower in the presence of serum from NSAID treated patients: thirty per cent less than observed in presence of normal serum in the RA group, and fifty per cent in the LDP group. When NSAIDs were withdrawn from RA patients, the LTB4 production in presence of serum increased, but was not completely normalized after one week. These results indicate that NSAID treatment may down-regulate the capacity for leukotriene synthesis by an indirect effect.",
keywords = "Leukotriene, NSAID, Prostaglandin, Rheumatoid arthritis, Serum",
author = "H. Gutheil and Nielsen, {O. H.} and Hansen, {T. M.} and Thomsen, {B. S.} and I. Ahnfelt-R{\o}nne",
year = "1996",
month = feb,
day = "5",
doi = "10.1007/BF02263502",
language = "English",
volume = "45",
pages = "31--34",
journal = "Inflammation Research",
issn = "1023-3830",
publisher = "Springer Basel AG",
number = "1",

}

RIS

TY - JOUR

T1 - Serum from NSAID-treated patients attenuates the capacity of rat leukocytes to synthesize leukotriene B4

AU - Gutheil, H.

AU - Nielsen, O. H.

AU - Hansen, T. M.

AU - Thomsen, B. S.

AU - Ahnfelt-Rønne, I.

PY - 1996/2/5

Y1 - 1996/2/5

N2 - The synthesis of leukotriene B4 by A23187-stimulated rat peritoneal leukocytes was studied in the presence of 0.1% normal human serum, serum from patients treated with NSAIDs for either an inflammatory (rheumatoid arthritis, RA) or a non-inflammatory condition (lumbar disc protrusion, LDP), and serum from RA patients drawn one week after withdrawal from NSAID treatment. The capacity for LTB4 synthesis was significantly lower in the presence of serum from NSAID treated patients: thirty per cent less than observed in presence of normal serum in the RA group, and fifty per cent in the LDP group. When NSAIDs were withdrawn from RA patients, the LTB4 production in presence of serum increased, but was not completely normalized after one week. These results indicate that NSAID treatment may down-regulate the capacity for leukotriene synthesis by an indirect effect.

AB - The synthesis of leukotriene B4 by A23187-stimulated rat peritoneal leukocytes was studied in the presence of 0.1% normal human serum, serum from patients treated with NSAIDs for either an inflammatory (rheumatoid arthritis, RA) or a non-inflammatory condition (lumbar disc protrusion, LDP), and serum from RA patients drawn one week after withdrawal from NSAID treatment. The capacity for LTB4 synthesis was significantly lower in the presence of serum from NSAID treated patients: thirty per cent less than observed in presence of normal serum in the RA group, and fifty per cent in the LDP group. When NSAIDs were withdrawn from RA patients, the LTB4 production in presence of serum increased, but was not completely normalized after one week. These results indicate that NSAID treatment may down-regulate the capacity for leukotriene synthesis by an indirect effect.

KW - Leukotriene

KW - NSAID

KW - Prostaglandin

KW - Rheumatoid arthritis

KW - Serum

UR - http://www.scopus.com/inward/record.url?scp=0030033239&partnerID=8YFLogxK

U2 - 10.1007/BF02263502

DO - 10.1007/BF02263502

M3 - Journal article

C2 - 8821776

AN - SCOPUS:0030033239

VL - 45

SP - 31

EP - 34

JO - Inflammation Research

JF - Inflammation Research

SN - 1023-3830

IS - 1

ER -

ID: 218718611