Selected strategies to fight pathogenic bacteria

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  • Aiva Plotniece
  • Arkadij Sobolev
  • Claudiu T Supuran
  • Fabrizio Carta
  • Björkling, Fredrik
  • Franzyk, Henrik
  • Jari Yli-Kauhaluoma
  • Koen Augustyns
  • Paul Cos
  • Linda De Vooght
  • Matthias Govaerts
  • Juliana Aizawa
  • Päivi Tammela
  • Raivis Žalubovskis

Natural products and analogues are a source of antibacterial drug discovery. Considering drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes and the synthesis of selective inhibitors are interesting for antibacterial agent development. Peptide nucleic acids are attractive antisense and antigene agents representing a novel strategy to target pathogens due to their unique mechanism of action. Antisense inhibition and development of antisense peptide nucleic acids is a new approach to antibacterial agents. Due to the increased resistance of biofilms to antibiotics, alternative therapeutic options are necessary. To develop antimicrobial strategies, optimised in vitro and in vivo models are needed. In vivo models to study biofilm-related respiratory infections, device-related infections: ventilator-associated pneumonia, tissue-related infections: chronic infection models based on alginate or agar beads, methods to battle biofilm-related infections are discussed. Drug delivery in case of antibacterials often is a serious issue therefore this review includes overview of drug delivery nanosystems.

Original languageEnglish
Article number2155816
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Issue number1
Number of pages27
Publication statusPublished - 2023

    Research areas

  • Peptide Nucleic Acids, Bacteria, Anti-Infective Agents, Anti-Bacterial Agents/pharmacology, Biofilms

ID: 332611667