School performance and genetic propensities for educational attainment and depression in the etiology of self-harm: a Danish population-based study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

School performance and genetic propensities for educational attainment and depression in the etiology of self-harm : a Danish population-based study. / Sørensen, Holger J; Antonsen, Sussie; Benros, Michael E; Erlangsen, Annette; Albiñana, Clara; Nordentoft, Merete; Børglum, Anders D; Mors, Ole; Werge, Thomas; Mortensen, Preben B; Hougaard, David; Webb, Roger T; Agerbo, Esben.

In: Nordic Journal of Psychiatry, Vol. 77, No. 2, 2023, p. 179-187.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sørensen, HJ, Antonsen, S, Benros, ME, Erlangsen, A, Albiñana, C, Nordentoft, M, Børglum, AD, Mors, O, Werge, T, Mortensen, PB, Hougaard, D, Webb, RT & Agerbo, E 2023, 'School performance and genetic propensities for educational attainment and depression in the etiology of self-harm: a Danish population-based study', Nordic Journal of Psychiatry, vol. 77, no. 2, pp. 179-187. https://doi.org/10.1080/08039488.2022.2078998

APA

Sørensen, H. J., Antonsen, S., Benros, M. E., Erlangsen, A., Albiñana, C., Nordentoft, M., Børglum, A. D., Mors, O., Werge, T., Mortensen, P. B., Hougaard, D., Webb, R. T., & Agerbo, E. (2023). School performance and genetic propensities for educational attainment and depression in the etiology of self-harm: a Danish population-based study. Nordic Journal of Psychiatry, 77(2), 179-187. https://doi.org/10.1080/08039488.2022.2078998

Vancouver

Sørensen HJ, Antonsen S, Benros ME, Erlangsen A, Albiñana C, Nordentoft M et al. School performance and genetic propensities for educational attainment and depression in the etiology of self-harm: a Danish population-based study. Nordic Journal of Psychiatry. 2023;77(2):179-187. https://doi.org/10.1080/08039488.2022.2078998

Author

Sørensen, Holger J ; Antonsen, Sussie ; Benros, Michael E ; Erlangsen, Annette ; Albiñana, Clara ; Nordentoft, Merete ; Børglum, Anders D ; Mors, Ole ; Werge, Thomas ; Mortensen, Preben B ; Hougaard, David ; Webb, Roger T ; Agerbo, Esben. / School performance and genetic propensities for educational attainment and depression in the etiology of self-harm : a Danish population-based study. In: Nordic Journal of Psychiatry. 2023 ; Vol. 77, No. 2. pp. 179-187.

Bibtex

@article{d42e5d24c5d1410b831cc9b5df8f9e46,
title = "School performance and genetic propensities for educational attainment and depression in the etiology of self-harm: a Danish population-based study",
abstract = "BACKGROUND: Poor school performance is linked to higher risks of self-harm. The association might be explained through genetic liabilities for depression or educational attainment. We investigated the association between school performance and self-harm in a population-based sample while assessing the potential influence of polygenic risk scores (PRSs) for depression (PRSMDD) and for educational attainment (PRSEDU).METHOD: We conducted a follow-up study of individuals born 1987-98 and followed from age 18 until 2016. The total sample consisted of a case group (23,779 diagnosed with mental disorders; schizophrenia, bipolar disorder, depression, autism, and attention deficit hyperactivity disorder (ADHD) and a randomly sampled comparison group (n = 10,925). Genome-wide data were obtained from the Neonatal Screening Biobank and information on school performance, family psychiatric history, and socioeconomic status from national administrative registers.RESULTS: Individuals in the top PRSMDD decile were at higher self-harm risk in the case group (IRR: 1.30; 95% CI 1.15-1.46), whereas individuals in the top PRSEDU decile were at lower self-harm risk (IRR: 0.63; 95% CI: 0.55-0.74). Poorer school performance was associated with higher self-harm risk in persons diagnosed with any mental disorder (IRR: 1.69; 95% CI: 1.44-1.99) and among the comparison group (IRR: 7.93; 95% CI: 4.47-15.18). Observed effects of PRSMDD and PRSEDU on self-harm risk were strongest for individuals with poor school performance.CONCLUSION: Associations between PRSMDD and self-harm risk and between PRSEDU and self-harm risk were found. Nevertheless, these polygenic scores seem currently of limited clinical utility for identifying individuals at high self-harm risk.",
author = "S{\o}rensen, {Holger J} and Sussie Antonsen and Benros, {Michael E} and Annette Erlangsen and Clara Albi{\~n}ana and Merete Nordentoft and B{\o}rglum, {Anders D} and Ole Mors and Thomas Werge and Mortensen, {Preben B} and David Hougaard and Webb, {Roger T} and Esben Agerbo",
year = "2023",
doi = "10.1080/08039488.2022.2078998",
language = "English",
volume = "77",
pages = "179--187",
journal = "Nordic Journal of Psychiatry, Supplement",
issn = "0803-9496",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - School performance and genetic propensities for educational attainment and depression in the etiology of self-harm

T2 - a Danish population-based study

AU - Sørensen, Holger J

AU - Antonsen, Sussie

AU - Benros, Michael E

AU - Erlangsen, Annette

AU - Albiñana, Clara

AU - Nordentoft, Merete

AU - Børglum, Anders D

AU - Mors, Ole

AU - Werge, Thomas

AU - Mortensen, Preben B

AU - Hougaard, David

AU - Webb, Roger T

AU - Agerbo, Esben

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Poor school performance is linked to higher risks of self-harm. The association might be explained through genetic liabilities for depression or educational attainment. We investigated the association between school performance and self-harm in a population-based sample while assessing the potential influence of polygenic risk scores (PRSs) for depression (PRSMDD) and for educational attainment (PRSEDU).METHOD: We conducted a follow-up study of individuals born 1987-98 and followed from age 18 until 2016. The total sample consisted of a case group (23,779 diagnosed with mental disorders; schizophrenia, bipolar disorder, depression, autism, and attention deficit hyperactivity disorder (ADHD) and a randomly sampled comparison group (n = 10,925). Genome-wide data were obtained from the Neonatal Screening Biobank and information on school performance, family psychiatric history, and socioeconomic status from national administrative registers.RESULTS: Individuals in the top PRSMDD decile were at higher self-harm risk in the case group (IRR: 1.30; 95% CI 1.15-1.46), whereas individuals in the top PRSEDU decile were at lower self-harm risk (IRR: 0.63; 95% CI: 0.55-0.74). Poorer school performance was associated with higher self-harm risk in persons diagnosed with any mental disorder (IRR: 1.69; 95% CI: 1.44-1.99) and among the comparison group (IRR: 7.93; 95% CI: 4.47-15.18). Observed effects of PRSMDD and PRSEDU on self-harm risk were strongest for individuals with poor school performance.CONCLUSION: Associations between PRSMDD and self-harm risk and between PRSEDU and self-harm risk were found. Nevertheless, these polygenic scores seem currently of limited clinical utility for identifying individuals at high self-harm risk.

AB - BACKGROUND: Poor school performance is linked to higher risks of self-harm. The association might be explained through genetic liabilities for depression or educational attainment. We investigated the association between school performance and self-harm in a population-based sample while assessing the potential influence of polygenic risk scores (PRSs) for depression (PRSMDD) and for educational attainment (PRSEDU).METHOD: We conducted a follow-up study of individuals born 1987-98 and followed from age 18 until 2016. The total sample consisted of a case group (23,779 diagnosed with mental disorders; schizophrenia, bipolar disorder, depression, autism, and attention deficit hyperactivity disorder (ADHD) and a randomly sampled comparison group (n = 10,925). Genome-wide data were obtained from the Neonatal Screening Biobank and information on school performance, family psychiatric history, and socioeconomic status from national administrative registers.RESULTS: Individuals in the top PRSMDD decile were at higher self-harm risk in the case group (IRR: 1.30; 95% CI 1.15-1.46), whereas individuals in the top PRSEDU decile were at lower self-harm risk (IRR: 0.63; 95% CI: 0.55-0.74). Poorer school performance was associated with higher self-harm risk in persons diagnosed with any mental disorder (IRR: 1.69; 95% CI: 1.44-1.99) and among the comparison group (IRR: 7.93; 95% CI: 4.47-15.18). Observed effects of PRSMDD and PRSEDU on self-harm risk were strongest for individuals with poor school performance.CONCLUSION: Associations between PRSMDD and self-harm risk and between PRSEDU and self-harm risk were found. Nevertheless, these polygenic scores seem currently of limited clinical utility for identifying individuals at high self-harm risk.

U2 - 10.1080/08039488.2022.2078998

DO - 10.1080/08039488.2022.2078998

M3 - Journal article

C2 - 35635301

VL - 77

SP - 179

EP - 187

JO - Nordic Journal of Psychiatry, Supplement

JF - Nordic Journal of Psychiatry, Supplement

SN - 0803-9496

IS - 2

ER -

ID: 323628130