Robustness of the Estimator of the Index of Dispersion for DNA Sequences

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Robustness of the Estimator of the Index of Dispersion for DNA Sequences. / Nielsen, Rasmus.

In: Molecular Phylogenetics and Evolution, Vol. 7, No. 3, 01.06.1997, p. 346-351.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, R 1997, 'Robustness of the Estimator of the Index of Dispersion for DNA Sequences', Molecular Phylogenetics and Evolution, vol. 7, no. 3, pp. 346-351. https://doi.org/10.1006/mpev.1997.0411

APA

Nielsen, R. (1997). Robustness of the Estimator of the Index of Dispersion for DNA Sequences. Molecular Phylogenetics and Evolution, 7(3), 346-351. https://doi.org/10.1006/mpev.1997.0411

Vancouver

Nielsen R. Robustness of the Estimator of the Index of Dispersion for DNA Sequences. Molecular Phylogenetics and Evolution. 1997 Jun 1;7(3):346-351. https://doi.org/10.1006/mpev.1997.0411

Author

Nielsen, Rasmus. / Robustness of the Estimator of the Index of Dispersion for DNA Sequences. In: Molecular Phylogenetics and Evolution. 1997 ; Vol. 7, No. 3. pp. 346-351.

Bibtex

@article{cfeadbb7bb6a46f2baa4c492454748d2,
title = "Robustness of the Estimator of the Index of Dispersion for DNA Sequences",
abstract = "If substitutions in DNA sequences follow a Poisson process, the ratio of the variance in the number of substitutions to the mean number of substitutions (the index of dispersion) should equal 1. In this paper, the robustness of the commonly applied estimator of the index of dispersion in replacement sites and silent sites to various assumptions regarding DNA evolution is explored using simulation methods. The estimate of the index of dispersion may be strongly biased if the assumptions of the model of substitution are violated. However, the results of this study support the conclusions of studies by Gillespie and Ohta that the process of substitution in replacement sites is overdispersed. This result contradicts those of a recent study and shows that the high index of dispersion for replacement sites is not an artifact caused by the method of estimation.",
author = "Rasmus Nielsen",
year = "1997",
month = jun,
day = "1",
doi = "10.1006/mpev.1997.0411",
language = "English",
volume = "7",
pages = "346--351",
journal = "Molecular Phylogenetics and Evolution",
issn = "1055-7903",
publisher = "Academic Press",
number = "3",

}

RIS

TY - JOUR

T1 - Robustness of the Estimator of the Index of Dispersion for DNA Sequences

AU - Nielsen, Rasmus

PY - 1997/6/1

Y1 - 1997/6/1

N2 - If substitutions in DNA sequences follow a Poisson process, the ratio of the variance in the number of substitutions to the mean number of substitutions (the index of dispersion) should equal 1. In this paper, the robustness of the commonly applied estimator of the index of dispersion in replacement sites and silent sites to various assumptions regarding DNA evolution is explored using simulation methods. The estimate of the index of dispersion may be strongly biased if the assumptions of the model of substitution are violated. However, the results of this study support the conclusions of studies by Gillespie and Ohta that the process of substitution in replacement sites is overdispersed. This result contradicts those of a recent study and shows that the high index of dispersion for replacement sites is not an artifact caused by the method of estimation.

AB - If substitutions in DNA sequences follow a Poisson process, the ratio of the variance in the number of substitutions to the mean number of substitutions (the index of dispersion) should equal 1. In this paper, the robustness of the commonly applied estimator of the index of dispersion in replacement sites and silent sites to various assumptions regarding DNA evolution is explored using simulation methods. The estimate of the index of dispersion may be strongly biased if the assumptions of the model of substitution are violated. However, the results of this study support the conclusions of studies by Gillespie and Ohta that the process of substitution in replacement sites is overdispersed. This result contradicts those of a recent study and shows that the high index of dispersion for replacement sites is not an artifact caused by the method of estimation.

UR - http://www.scopus.com/inward/record.url?scp=0031154080&partnerID=8YFLogxK

U2 - 10.1006/mpev.1997.0411

DO - 10.1006/mpev.1997.0411

M3 - Journal article

C2 - 9187093

AN - SCOPUS:0031154080

VL - 7

SP - 346

EP - 351

JO - Molecular Phylogenetics and Evolution

JF - Molecular Phylogenetics and Evolution

SN - 1055-7903

IS - 3

ER -

ID: 222646796