Roadmap to 3D printed oral pharmaceutical dosage forms

Roadmap to 3D printed oral pharmaceutical dosage forms: Feedstock filament properties and characterization for fused deposition modeling

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Roadmap to 3D printed oral pharmaceutical dosage forms : Feedstock filament properties and characterization for fused deposition modeling. / Aho, J; Bøtker, J P; Genina, N; Edinger, M; Arnfast, L; Rantanen, J.

In: Journal of Pharmaceutical Sciences, Vol. 108, No. 1, 01.2019, p. 26–35.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Aho, J, Bøtker, JP, Genina, N, Edinger, M, Arnfast, L & Rantanen, J 2019, 'Roadmap to 3D printed oral pharmaceutical dosage forms: Feedstock filament properties and characterization for fused deposition modeling', Journal of Pharmaceutical Sciences, vol. 108, no. 1, pp. 26–35. https://doi.org/10.1016/j.xphs.2018.11.012

APA

Aho, J., Bøtker, J. P., Genina, N., Edinger, M., Arnfast, L., & Rantanen, J. (2019). Roadmap to 3D printed oral pharmaceutical dosage forms: Feedstock filament properties and characterization for fused deposition modeling. Journal of Pharmaceutical Sciences, 108(1), 26–35. https://doi.org/10.1016/j.xphs.2018.11.012

Vancouver

Aho J, Bøtker JP, Genina N, Edinger M, Arnfast L, Rantanen J. Roadmap to 3D printed oral pharmaceutical dosage forms: Feedstock filament properties and characterization for fused deposition modeling. Journal of Pharmaceutical Sciences. 2019 Jan;108(1):26–35. https://doi.org/10.1016/j.xphs.2018.11.012

Author

Aho, J ; Bøtker, J P ; Genina, N ; Edinger, M ; Arnfast, L ; Rantanen, J. / Roadmap to 3D printed oral pharmaceutical dosage forms : Feedstock filament properties and characterization for fused deposition modeling. In: Journal of Pharmaceutical Sciences. 2019 ; Vol. 108, No. 1. pp. 26–35.

Bibtex

@article{c568429b69d24a689793fce3a210a934,

title = "Roadmap to 3D printed oral pharmaceutical dosage forms: Feedstock filament properties and characterization for fused deposition modeling",

abstract = "Application of additive manufacturing techniques (3D printing) for mass-customized products has boomed in the recent years. In pharmaceutical industry and research, the interest has grown particularly with the future scenario of more personalized medicinal products. Understanding a broad range of material properties and process behavior of the drug-excipient combinations is necessary for successful 3D printing of dosage forms. This commentary reviews recent 3D printing studies by fused deposition modeling (FDM) technique in pharmaceutical sciences, extending into the fields of polymer processing and rapid prototyping, where more in-depth studies on the feedstock material properties, modeling and simulation of the FDM process have been performed. A case study of a model oral dosage form from custom-prepared indomethacin-polycaprolactone feedstock filament was used as an example in the pharmaceutical context. The printability was assessed in the different process steps: preparation of customized filaments for FDM, filament feeding, deposition, and solidification. These were linked with the rheological, thermal, and mechanical properties and their characterization, relevant for understanding the printability of drug products by FDM.",

author = "J Aho and B{\o}tker, {J P} and N Genina and M Edinger and L Arnfast and J Rantanen",

year = "2019",

month = jan,

doi = "10.1016/j.xphs.2018.11.012",

language = "English",

volume = "108",

pages = "26–35",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Roadmap to 3D printed oral pharmaceutical dosage forms

T2 - Feedstock filament properties and characterization for fused deposition modeling

AU - Aho, J

AU - Bøtker, J P

AU - Genina, N

AU - Edinger, M

AU - Arnfast, L

AU - Rantanen, J

PY - 2019/1

Y1 - 2019/1

N2 - Application of additive manufacturing techniques (3D printing) for mass-customized products has boomed in the recent years. In pharmaceutical industry and research, the interest has grown particularly with the future scenario of more personalized medicinal products. Understanding a broad range of material properties and process behavior of the drug-excipient combinations is necessary for successful 3D printing of dosage forms. This commentary reviews recent 3D printing studies by fused deposition modeling (FDM) technique in pharmaceutical sciences, extending into the fields of polymer processing and rapid prototyping, where more in-depth studies on the feedstock material properties, modeling and simulation of the FDM process have been performed. A case study of a model oral dosage form from custom-prepared indomethacin-polycaprolactone feedstock filament was used as an example in the pharmaceutical context. The printability was assessed in the different process steps: preparation of customized filaments for FDM, filament feeding, deposition, and solidification. These were linked with the rheological, thermal, and mechanical properties and their characterization, relevant for understanding the printability of drug products by FDM.

AB - Application of additive manufacturing techniques (3D printing) for mass-customized products has boomed in the recent years. In pharmaceutical industry and research, the interest has grown particularly with the future scenario of more personalized medicinal products. Understanding a broad range of material properties and process behavior of the drug-excipient combinations is necessary for successful 3D printing of dosage forms. This commentary reviews recent 3D printing studies by fused deposition modeling (FDM) technique in pharmaceutical sciences, extending into the fields of polymer processing and rapid prototyping, where more in-depth studies on the feedstock material properties, modeling and simulation of the FDM process have been performed. A case study of a model oral dosage form from custom-prepared indomethacin-polycaprolactone feedstock filament was used as an example in the pharmaceutical context. The printability was assessed in the different process steps: preparation of customized filaments for FDM, filament feeding, deposition, and solidification. These were linked with the rheological, thermal, and mechanical properties and their characterization, relevant for understanding the printability of drug products by FDM.

U2 - 10.1016/j.xphs.2018.11.012

DO - 10.1016/j.xphs.2018.11.012

M3 - Journal article

C2 - 30445005

VL - 108

SP - 26

EP - 35

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 1

ER -

ID: 209680008