Risk of psoriasis in patients with childhood asthma: a Danish nationwide cohort study
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Risk of psoriasis in patients with childhood asthma : a Danish nationwide cohort study. / Egeberg, A; Khalid, U; Gislason, G H; Mallbris, L; Skov, L; Hansen, P R.
In: British Journal of Dermatology, Vol. 173, No. 1, 07.2015, p. 159-64.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Risk of psoriasis in patients with childhood asthma
T2 - a Danish nationwide cohort study
AU - Egeberg, A
AU - Khalid, U
AU - Gislason, G H
AU - Mallbris, L
AU - Skov, L
AU - Hansen, P R
N1 - © 2015 British Association of Dermatologists.
PY - 2015/7
Y1 - 2015/7
N2 - BACKGROUND: Psoriasis and asthma are disorders driven by inflammation. Psoriasis may carry an increased risk of asthma, but the reverse relationship has not been investigated.OBJECTIVES: To investigate the risk of psoriasis in subjects with childhood asthma in a nationwide Danish cohort.METHODS: Data on all Danish individuals aged 6-14 years at study entry between 1 January 1997 and 31 December 2011 (n = 1,478,110) were linked at an individual level in nationwide registers. Incidence rates per 10,000 person-years were calculated, and incidence rate ratios (IRRs) adjusted for age, sex, concomitant medication and comorbidity were estimated by Poisson regression models.RESULTS: There were 21,725 cases of childhood asthma and 6586 incident cases of psoriasis. There were 5697 and 889 incident cases of mild and severe psoriasis, respectively. The incidence rates of overall, mild and severe psoriasis were 4.49, 3.88 and 0.61 for the reference population, and 5.95, 5.18 and 0.83 for subjects with childhood asthma, respectively. The IRRs for overall, mild and severe psoriasis were 3.94 [95% confidence interval (CI) 2.16-7.17], 5.03 (95% CI 2.48-10.21) and 2.27 (95% CI 0.61-8.42) for patients with childhood asthma.CONCLUSIONS: Childhood asthma was associated with a significantly increased risk of psoriasis. Further studies are warranted to determine the clinical significance and effects of therapeutic interventions on this association.
AB - BACKGROUND: Psoriasis and asthma are disorders driven by inflammation. Psoriasis may carry an increased risk of asthma, but the reverse relationship has not been investigated.OBJECTIVES: To investigate the risk of psoriasis in subjects with childhood asthma in a nationwide Danish cohort.METHODS: Data on all Danish individuals aged 6-14 years at study entry between 1 January 1997 and 31 December 2011 (n = 1,478,110) were linked at an individual level in nationwide registers. Incidence rates per 10,000 person-years were calculated, and incidence rate ratios (IRRs) adjusted for age, sex, concomitant medication and comorbidity were estimated by Poisson regression models.RESULTS: There were 21,725 cases of childhood asthma and 6586 incident cases of psoriasis. There were 5697 and 889 incident cases of mild and severe psoriasis, respectively. The incidence rates of overall, mild and severe psoriasis were 4.49, 3.88 and 0.61 for the reference population, and 5.95, 5.18 and 0.83 for subjects with childhood asthma, respectively. The IRRs for overall, mild and severe psoriasis were 3.94 [95% confidence interval (CI) 2.16-7.17], 5.03 (95% CI 2.48-10.21) and 2.27 (95% CI 0.61-8.42) for patients with childhood asthma.CONCLUSIONS: Childhood asthma was associated with a significantly increased risk of psoriasis. Further studies are warranted to determine the clinical significance and effects of therapeutic interventions on this association.
KW - Adolescent
KW - Asthma
KW - Child
KW - Denmark
KW - Epidemiologic Methods
KW - Female
KW - Humans
KW - Male
KW - Psoriasis
U2 - 10.1111/bjd.13781
DO - 10.1111/bjd.13781
M3 - Journal article
C2 - 25801416
VL - 173
SP - 159
EP - 164
JO - British Journal of Dermatology
JF - British Journal of Dermatology
SN - 0007-0963
IS - 1
ER -
ID: 162030867