Risk of breast cancer among women with benign ovarian tumors: a Danish nationwide cohort study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Risk of breast cancer among women with benign ovarian tumors : a Danish nationwide cohort study. / Gottschau, Mathilde; Jensen, Allan; Reinholdt, Kristian; Guleria, Sonia; Munk, Christian; Mellemkjær, Lene; Kjær, Susanne K.
In: Breast Cancer Research and Treatment, Vol. 178, No. 1, 11.2019, p. 199-205.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Risk of breast cancer among women with benign ovarian tumors
T2 - a Danish nationwide cohort study
AU - Gottschau, Mathilde
AU - Jensen, Allan
AU - Reinholdt, Kristian
AU - Guleria, Sonia
AU - Munk, Christian
AU - Mellemkjær, Lene
AU - Kjær, Susanne K
PY - 2019/11
Y1 - 2019/11
N2 - PURPOSE: To assess the association between benign ovarian tumors and subsequent risk of breast cancer, and to examine this association according to type of benign ovarian tumors.METHODS: This nationwide cohort study comprised all Danish women diagnosed with a benign ovarian tumor during 1978-2016 (n = 158,221) identified through the Danish National Patient Register. The cohort was linked to the Danish Cancer Registry to identify all cases of breast cancer, and standardized incidence ratios (SIR) and 95% confidence intervals (CI) were calculated.RESULTS: Overall, women with a benign ovarian tumor were at significantly increased risk of breast cancer. The risk was confined to women with a solid ovarian tumor (SIR 1.09; 95% CI 1.05-1.13), particularly in women ≥ 50 years at benign tumor diagnosis (SIR 1.19; 95% CI 1.12-1.26). The risk remained increased up to 20 years or more after the diagnosis of a solid ovarian tumor (SIR 1.11; 95% CI 1.04-1.18), and women with a solid tumor were at increased risk of ductal, lobular, and other types of breast cancer, although most consistent for the lobular subtype. For cystic tumors, this association was confined to ductal breast cancer in women with the tumor diagnosed at age ≥ 50 years.CONCLUSIONS: Women with a benign ovarian tumor were at increased risk of breast cancer. This association was largely confined to women with a solid ovarian tumor, and the excess risk was present 20 years or more after the ovarian tumor diagnosis. The underlying mechanism is unknown and should be investigated further.
AB - PURPOSE: To assess the association between benign ovarian tumors and subsequent risk of breast cancer, and to examine this association according to type of benign ovarian tumors.METHODS: This nationwide cohort study comprised all Danish women diagnosed with a benign ovarian tumor during 1978-2016 (n = 158,221) identified through the Danish National Patient Register. The cohort was linked to the Danish Cancer Registry to identify all cases of breast cancer, and standardized incidence ratios (SIR) and 95% confidence intervals (CI) were calculated.RESULTS: Overall, women with a benign ovarian tumor were at significantly increased risk of breast cancer. The risk was confined to women with a solid ovarian tumor (SIR 1.09; 95% CI 1.05-1.13), particularly in women ≥ 50 years at benign tumor diagnosis (SIR 1.19; 95% CI 1.12-1.26). The risk remained increased up to 20 years or more after the diagnosis of a solid ovarian tumor (SIR 1.11; 95% CI 1.04-1.18), and women with a solid tumor were at increased risk of ductal, lobular, and other types of breast cancer, although most consistent for the lobular subtype. For cystic tumors, this association was confined to ductal breast cancer in women with the tumor diagnosed at age ≥ 50 years.CONCLUSIONS: Women with a benign ovarian tumor were at increased risk of breast cancer. This association was largely confined to women with a solid ovarian tumor, and the excess risk was present 20 years or more after the ovarian tumor diagnosis. The underlying mechanism is unknown and should be investigated further.
KW - Adult
KW - Age of Onset
KW - Aged
KW - Aged, 80 and over
KW - Breast Neoplasms/epidemiology
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Female
KW - Humans
KW - Middle Aged
KW - Ovarian Neoplasms/epidemiology
KW - Registries
KW - Young Adult
U2 - 10.1007/s10549-019-05369-8
DO - 10.1007/s10549-019-05369-8
M3 - Journal article
C2 - 31364000
VL - 178
SP - 199
EP - 205
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 1
ER -
ID: 236990463