Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages

Research output: Contribution to journalJournal articleResearchpeer-review

Derivatives of 4-aminomethyl-l-phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C-terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.

Original languageEnglish
JournalAngewandte Chemie - International Edition
Issue number12
Pages (from-to)4860-4864
Number of pages5
Publication statusPublished - 16 Mar 2020
Externally publishedYes

    Research areas

  • flexizyme, foldamers, in vitro translation, peptides, peptidomimetics

ID: 243921596