Respiratory gating in cardiac PET: Effects of adenosine and dipyridamole
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND: Respiratory motion due to breathing during cardiac positron emission tomography (PET) results in spatial blurring and erroneous tracer quantification. Respiratory gating might represent a solution by dividing the PET coincidence dataset into smaller respiratory phase subsets. The aim of our study was to compare the resulting imaging quality by the use of a time-based respiratory gating system in two groups administered either adenosine or dipyridamole as the pharmacological stress agent.
METHODS AND RESULTS: Forty-eight patients were randomized to adenosine or dipyridamole cardiac stress (82)RB-PET. Respiratory rates and depths were measured by a respiratory gating system in addition to registering actual respiratory rates. Patients undergoing adenosine stress showed a decrease in measured respiratory rate from initial to later scan phase measurements [12.4 (±5.7) vs 5.6 (±4.7) min(-1), P < .001] and tended to have a lower frequency of successful respiratory gating compared to dipyridamole (47% vs 71%, P = .12). As a result, imaging quality was superior in the dipyridamole group compared to adenosine.
CONCLUSIONS: If respiratory gating is considered for use in cardiac PET, a dipyridamole stress protocol is recommended as it, compared to adenosine, causes a more uniform respiration and results in a higher frequency of successful respiratory gating and thereby superior imaging quality.
Original language | English |
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Journal | Journal of Nuclear Cardiology |
Volume | 24 |
Issue number | 6 |
Pages (from-to) | 1941–1949 |
ISSN | 1071-3581 |
DOIs | |
Publication status | Published - Dec 2017 |
- Journal Article
Research areas
ID: 173478548