Renal Aquaporins in Health and Disease

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Aquaporins (AQPs) are a large family of membrane proteins that act as semipermeable channels. The majority of AQPs are permeable to water, but a subset of the family can also transport glycerol, urea, and other small solutes. Currently, 13 AQP homologues have been identified in mammals, termed AQP0–12. These aquaporins are highly abundant in epithelial cells and non-epithelial cells in various tissues including the kidney, brain, liver, lungs, and salivary glands. In this chapter we focus on AQPs expressed in kidney epithelial cells. We summarize the current knowledge with respect to their localization and function within the kidney tubule and their critical role in mammalian water homeostasis. We describe a number of water balance disorders resulting from altered AQP function and provide an overview of some of the treatment strategies for these disorders.
Original languageEnglish
Title of host publication Ion Channels and Transporters of Epithelia in Health and Disease
Number of pages52
Publication date2016
ISBN (Print)978-1-4939-3364-8
ISBN (Electronic)978-1-4939-3366-2
Publication statusPublished - 2016
Externally publishedYes
SeriesPhysiology in Health and Disease

ID: 161161446