Remnant cholesterol and low-grade inflammation jointly in atherosclerotic cardiovascular disease: Implications for clinical trials
Research output: Contribution to journal › Review › Research › peer-review
Purpose of reviewAtherosclerotic cardiovascular disease (ASCVD) is the leading cause of death despite the development of effective treatments. Recently, elevated remnant cholesterol and low-grade inflammation have emerged as factors explaining part of the residual ASCVD risk. Interestingly, the coexistence of both high remnant cholesterol and low-grade inflammation can further increase the risk of ASCVD. The aim of this review is to describe the role of elevated remnant cholesterol and low-grade inflammation, separately and combined, in ASCVD.Recent findingsResults from recently published studies, including observational and genetic Mendelian randomization studies, support a causal relationship between elevated remnant cholesterol and low-grade inflammation on risk of ASCVD in both primary and secondary prevention settings. In addition, current evidence from observational studies suggests that the coexistence of elevated remnant cholesterol and low-grade inflammation further increases the risk of ASCVD.SummaryRecent observational studies suggest that high remnant cholesterol combined with low-grade inflammation may confer a particular high risk for ASCVD. Attention on the dual threat from high remnant cholesterol and low-grade inflammation is necessary, and further research in this field is warranted. The effect of remnant cholesterol-lowering drugs and anti-inflammatory drugs on ASCVD risk alone and combined remains to be elucidated.Video abstracthttp://links.lww.com/COCN/A20.
Original language | English |
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Journal | Current Opinion in Clinical Nutrition and Metabolic Care |
Volume | 27 |
Issue number | 2 |
Pages (from-to) | 125-135 |
Number of pages | 11 |
ISSN | 1363-1950 |
DOIs | |
Publication status | Published - 2024 |
Bibliographical note
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- C-reactive protein, low-density lipoprotein cholesterol, triglyceride-rich lipoproteins, triglycerides, very low-density lipoprotein
Research areas
ID: 384570473