Rate constant ratios of the reactions of CF₃O radicals with a number of hydrocarbons have been determined at 298 ± 2 K and atmospheric pressure using a relative rate method. Using a previously determined value k(CF₃O+C₂H₆) = 1.2×10^-12 cm³ molecule^-1 s^-1 these rate constant ratios provide estimates of the rate constants: k(CF₃O+CH₄) = (1.2±0.1)×10^-14, k(CF₃O+c-C₃H₆) = (3.6±0.2)×10^-13, k(CF₃O+C₃H₈) = (4.7±0.7)×10^-12, k(CF₃O+(CH₃)₃CH) = (7.2±0.5)×10^-12, k(CF₃O+C₂H₄) = (3.0±0.1)×10^-11 and k(CF₃O+C₆H₆) = (3.6±0.1)×10^-11 cm³ molecule^-1 s^-1. The importance of the reactions of CF₃O radicals with hydrocarbons under atmospheric conditions is discussed.