Rapid functional upregulation of vasocontractile endothelin ETB receptors in rat coronary arteries

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Endothelin ET(B) receptors mediate under normal physiological conditions vasorelaxation in coronary arteries. However, vasocontractile ET(B) receptors appear in coronary arteries of ischemic heart disease patients. Interestingly, organ culture of isolated coronary arteries also induces upregulation of vasocontractile ET(B) receptors. This study examines the early time course and mechanism behind upregulation of contractile ET(B) receptors in isolated rat coronary arteries during short-term organ culture.
Original languageEnglish
JournalLife Sciences
Issue number13-14
Pages (from-to)593-9
Number of pages7
Publication statusPublished - 2012

ID: 40968474