Racial/Ethnic Differences in Incidence and Persistence of Childhood Atopic Dermatitis
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Racial/Ethnic Differences in Incidence and Persistence of Childhood Atopic Dermatitis. / Kim, Yuhree; Blomberg, Maria; Rifas-Shiman, Sheryl L.; Camargo, Carlos A.; Gold, Diane R.; Thyssen, Jacob P.; Litonjua, Augusto A.; Oken, Emily; Asgari, Maryam M.
In: Journal of Investigative Dermatology, Vol. 139, No. 4, 04.2019, p. 827-834.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Racial/Ethnic Differences in Incidence and Persistence of Childhood Atopic Dermatitis
AU - Kim, Yuhree
AU - Blomberg, Maria
AU - Rifas-Shiman, Sheryl L.
AU - Camargo, Carlos A.
AU - Gold, Diane R.
AU - Thyssen, Jacob P.
AU - Litonjua, Augusto A.
AU - Oken, Emily
AU - Asgari, Maryam M.
PY - 2019/4
Y1 - 2019/4
N2 - Although previous studies have explored racial/ethnic differences in incident atopic dermatitis (AD) in childhood, few studies have examined risk factors associated with AD persistence. As such, we sought to examine differences in incidence and persistence of childhood AD by race/ethnicity accounting for sociodemographic characteristics and perinatal vitamin D levels. Using data from Project Viva, a prospective prebirth cohort in eastern Massachusetts, we studied 1,437 mother-child pairs with known AD status to examine the associations of race/ethnicity with maternally reported child AD. We used multivariable logistic regression, adjusting for sociodemographic factors and maternal plasma vitamin D, to estimate adjusted odds ratios (aORs) of AD incidence at early childhood and persistence at mid-childhood. Compared to non-Hispanic whites, non-Hispanic blacks (aOR = 2.71, 95% confidence interval = 1.75–4.19) and other non-Hispanics (aOR = 1.80, 95% confidence interval = 1.16–2.80) were more likely to have incident AD. Non-Hispanic blacks (aOR = 6.26, 95% confidence interval = 2.32–16.88) and Hispanics (aOR = 6.42, 95% CI = 1.93–21.41) with early childhood AD were more likely to have persistent AD. In conclusion, compared with non-Hispanic whites, AD incidence and persistence are higher among certain nonwhite racial/ethnic subgroups. Further research is warranted to identify environmental, socioeconomic, and genetic factors that may be responsible for the observed differences.
AB - Although previous studies have explored racial/ethnic differences in incident atopic dermatitis (AD) in childhood, few studies have examined risk factors associated with AD persistence. As such, we sought to examine differences in incidence and persistence of childhood AD by race/ethnicity accounting for sociodemographic characteristics and perinatal vitamin D levels. Using data from Project Viva, a prospective prebirth cohort in eastern Massachusetts, we studied 1,437 mother-child pairs with known AD status to examine the associations of race/ethnicity with maternally reported child AD. We used multivariable logistic regression, adjusting for sociodemographic factors and maternal plasma vitamin D, to estimate adjusted odds ratios (aORs) of AD incidence at early childhood and persistence at mid-childhood. Compared to non-Hispanic whites, non-Hispanic blacks (aOR = 2.71, 95% confidence interval = 1.75–4.19) and other non-Hispanics (aOR = 1.80, 95% confidence interval = 1.16–2.80) were more likely to have incident AD. Non-Hispanic blacks (aOR = 6.26, 95% confidence interval = 2.32–16.88) and Hispanics (aOR = 6.42, 95% CI = 1.93–21.41) with early childhood AD were more likely to have persistent AD. In conclusion, compared with non-Hispanic whites, AD incidence and persistence are higher among certain nonwhite racial/ethnic subgroups. Further research is warranted to identify environmental, socioeconomic, and genetic factors that may be responsible for the observed differences.
U2 - 10.1016/j.jid.2018.10.029
DO - 10.1016/j.jid.2018.10.029
M3 - Journal article
C2 - 30414911
AN - SCOPUS:85060336197
VL - 139
SP - 827
EP - 834
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
SN - 0022-202X
IS - 4
ER -
ID: 240411995