Pseudoxylallemycins A-F, cyclic tetrapeptides with rare allenyl modifications isolated from Pseudoxylaria sp. X802: a competitor of fungus-growing termite cultivars
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Based on fungus-fungus pairing assays and HRMS-based dereplication strategy, six new cyclic tetrapeptides, pseudoxylallemycins A-F (1-6), were isolated from the termite-associated fungus Pseudoxylaria sp. X802. Structures were characterized using NMR spectroscopy, HRMS, and Marfey's reaction. Pseudoxylallemycins B-D (2-4) possess a rare and chemically accessible allene moiety amenable for synthetic modifications, and derivatives A-D showed antimicrobial activity against Gram-negative human-pathogenic Pseudomonas aeruginosa and antiproliferative activity against human umbilical vein endothelial cells and K-562 cell lines.
Original language | English |
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Journal | Organic Letters |
Volume | 18 |
Issue number | 14 |
Pages (from-to) | 3338-3341 |
Number of pages | 4 |
ISSN | 1523-7060 |
DOIs | |
Publication status | Published - 2016 |
- Journal Article
Research areas
ID: 169945955