Productive vs non-productive chronic cough associated with worse lung health and higher morbidity and mortality in the general population
Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Background: Whether productive or non-productive chronic cough is worse in the general population is unknown. We tested the hypothesis that productive vs non-productive chronic cough is associated with worse lung health and higher morbidity and mortality in the general population.
Methods: We included 44,436 random adults from the Copenhagen General Population Study, and defined productive chronic cough as a cough lasting more than 8 weeks with mucus production during the day as long as 3 consecutive months a year. We investigated differences in lung function, accompanying respiratory symptoms, morbidity, and mortality.
Results: Among 44,436 individuals, 1416 (3%) had productive chronic cough and 1380 (3%) non-productive chronic cough. Individuals with productive vs non-productive chronic cough had lower lung function (FEV1 88% vs 95% predicted, FVC 97% vs 101% predicted, and FEV1/FVC 0.72 vs 0.75), and more often accompanying respiratory symptoms (dyspnoea 5% vs 3% and wheezing 53% vs 29%), gastro-oesophageal reflux disease (36% vs 28%), and diabetes (11% vs 7%), and higher levels of inflammatory biomarkers in blood at baseline examination. Individuals with productive chronic cough vs controls had adjusted hazard ratios (HRs) of 7.2 (95% confidence interval: 4.3-12) for COPD exacerbation, 2.9 (2.2-3.8) for pneumonia, and 2.1 (1.6-2.6) for all-cause mortality. Corresponding HRs for non-productive chronic cough were 3.0 (1.4-6.2), 1.8 (1.2-2.5), and 1.5 (1.1-2.1), respectively.
Conclusion: Individuals with productive versus non-productive chronic cough have worse lung health and higher risk of morbidity and mortality.
Methods: We included 44,436 random adults from the Copenhagen General Population Study, and defined productive chronic cough as a cough lasting more than 8 weeks with mucus production during the day as long as 3 consecutive months a year. We investigated differences in lung function, accompanying respiratory symptoms, morbidity, and mortality.
Results: Among 44,436 individuals, 1416 (3%) had productive chronic cough and 1380 (3%) non-productive chronic cough. Individuals with productive vs non-productive chronic cough had lower lung function (FEV1 88% vs 95% predicted, FVC 97% vs 101% predicted, and FEV1/FVC 0.72 vs 0.75), and more often accompanying respiratory symptoms (dyspnoea 5% vs 3% and wheezing 53% vs 29%), gastro-oesophageal reflux disease (36% vs 28%), and diabetes (11% vs 7%), and higher levels of inflammatory biomarkers in blood at baseline examination. Individuals with productive chronic cough vs controls had adjusted hazard ratios (HRs) of 7.2 (95% confidence interval: 4.3-12) for COPD exacerbation, 2.9 (2.2-3.8) for pneumonia, and 2.1 (1.6-2.6) for all-cause mortality. Corresponding HRs for non-productive chronic cough were 3.0 (1.4-6.2), 1.8 (1.2-2.5), and 1.5 (1.1-2.1), respectively.
Conclusion: Individuals with productive versus non-productive chronic cough have worse lung health and higher risk of morbidity and mortality.
Original language | English |
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Article number | 4029 |
Journal | European Respiratory Journal |
Volume | 60 |
Issue number | suppl 66 |
Number of pages | 1 |
ISSN | 0903-1936 |
DOIs | |
Publication status | Published - 2022 |
Event | ERS International Congress 2022 - Barcelona, Barcelona, Spain Duration: 4 Sep 2022 → 6 Sep 2022 https://www.ersnet.org/congress-and-events/congress/venue-hotel-and-travel-information/venue/ |
Conference
Conference | ERS International Congress 2022 |
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Location | Barcelona |
Country | Spain |
City | Barcelona |
Period | 04/09/2022 → 06/09/2022 |
Internet address |
ID: 357996643