TY - JOUR

T1 - Printing technologies in fabrication of drug delivery systems.

AU - Kolakovic, Ruzica

AU - Viitala, Tapani

AU - Ihalainen, Petri

AU - Genina, Natalja

AU - Peltonen, Jouko

AU - Sandler, Niklas

PY - 2013

Y1 - 2013

N2 - INTRODUCTION: There has been increased activity in the field recently regarding the development and research on various printing techniques in fabrication of dosage forms and drug delivery systems. These technologies may offer benefits and flexibility in manufacturing, potentially paving the way for personalized dosing and tailor-made dosage forms.\n\nAREAS COVERED: In this review, the most recent observations and advancements in fabrication of drug delivery systems by utilizing printing technologies are summarized. A general overview of 2D printing techniques is presented including a review of the most recent literature where printing techniques are used in fabrication of drug delivery systems. The future perspectives and possible impacts on formulation strategies, flexible dosing and personalized medication of using printing techniques for fabrication of drug delivery systems are discussed.\n\nEXPERT OPINION: It is evident that there is an urgent need to meet the challenges of rapidly growing trend of personalization of medicines through development of flexible drug-manufacturing approaches. In this context, various printing technologies, such as inkjet and flexography, can play an important role. Challenges on different levels exist and include: i) technological development of printers and production lines; ii) printable formulations and carrier substrates; iii) quality control and characterization; and iv) regulatory perspectives.

AB - INTRODUCTION: There has been increased activity in the field recently regarding the development and research on various printing techniques in fabrication of dosage forms and drug delivery systems. These technologies may offer benefits and flexibility in manufacturing, potentially paving the way for personalized dosing and tailor-made dosage forms.\n\nAREAS COVERED: In this review, the most recent observations and advancements in fabrication of drug delivery systems by utilizing printing technologies are summarized. A general overview of 2D printing techniques is presented including a review of the most recent literature where printing techniques are used in fabrication of drug delivery systems. The future perspectives and possible impacts on formulation strategies, flexible dosing and personalized medication of using printing techniques for fabrication of drug delivery systems are discussed.\n\nEXPERT OPINION: It is evident that there is an urgent need to meet the challenges of rapidly growing trend of personalization of medicines through development of flexible drug-manufacturing approaches. In this context, various printing technologies, such as inkjet and flexography, can play an important role. Challenges on different levels exist and include: i) technological development of printers and production lines; ii) printable formulations and carrier substrates; iii) quality control and characterization; and iv) regulatory perspectives.

KW - 10

KW - 12

KW - 1711-1723

KW - 2013

KW - drop-on-demand

KW - drug deliv

KW - expert opin

KW - flexography

KW - inkjet

KW - personalized dosing

KW - printing technologies

KW - roll-to-roll

KW - screen printing

U2 - 10.1517/17425247.2013.859134

DO - 10.1517/17425247.2013.859134

M3 - Journal article

C2 - 24256326

SP - 1711

EP - 1723

JO - Expert Opinion on Drug Delivery

JF - Expert Opinion on Drug Delivery

SN - 1742-5247

ER -