Preparation of Co-Amorphous Systems by Freeze-Drying

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Preparation of Co-Amorphous Systems by Freeze-Drying. / Wostry, Melvin; Plappert, Hanna; Grohganz, Holger.

In: Pharmaceutics, Vol. 12, No. 10, 941, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wostry, M, Plappert, H & Grohganz, H 2020, 'Preparation of Co-Amorphous Systems by Freeze-Drying', Pharmaceutics, vol. 12, no. 10, 941. https://doi.org/10.3390/pharmaceutics12100941

APA

Wostry, M., Plappert, H., & Grohganz, H. (2020). Preparation of Co-Amorphous Systems by Freeze-Drying. Pharmaceutics, 12(10), [941]. https://doi.org/10.3390/pharmaceutics12100941

Vancouver

Wostry M, Plappert H, Grohganz H. Preparation of Co-Amorphous Systems by Freeze-Drying. Pharmaceutics. 2020;12(10). 941. https://doi.org/10.3390/pharmaceutics12100941

Author

Wostry, Melvin ; Plappert, Hanna ; Grohganz, Holger. / Preparation of Co-Amorphous Systems by Freeze-Drying. In: Pharmaceutics. 2020 ; Vol. 12, No. 10.

Bibtex

@article{40adcaeb08714c319c8c907317fcaf7c,
title = "Preparation of Co-Amorphous Systems by Freeze-Drying",
abstract = "Freeze-drying was evaluated as a production technique for co-amorphous systems of a poorly water-soluble drug. Naproxen was freeze-dried together with arginine and lysine as co-former. To increase the solubility of naproxen in the starting solution, the applicability of five surfactants was investigated, namely sodium dodecyl sulfate, pluronic F-127, polyoxyethylene (40) stearate, tween 20 and TPGS 1000. The influence of the surfactant type, surfactant concentration and total solid content to be freeze-dried on the solid state of the sample was investigated. X-ray powder diffraction and differential scanning calorimetry showed that the majority of systems formed co-amorphous one-phase systems. However, at higher surfactant concentrations, and depending on the surfactant type, surfactant reflections were observed in the XRPD analysis upon production. Crystallization of both naproxen and amino acid occurred from some combinations under storage. In conclusion, freeze-drying was shown to be a feasible technique for the production of a selection of co-amorphous drug-amino acid formulations.",
keywords = "co-amorphous, freeze-drying, surfactant, WATER-SOLUBLE DRUGS, AMINO-ACIDS, ENHANCED DISSOLUTION, BINARY-SYSTEMS, STABILITY, FORMULATIONS, SOLUBILITY, SACCHARIN, BEHAVIOR, IMPROVE",
author = "Melvin Wostry and Hanna Plappert and Holger Grohganz",
year = "2020",
doi = "10.3390/pharmaceutics12100941",
language = "English",
volume = "12",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "10",

}

RIS

TY - JOUR

T1 - Preparation of Co-Amorphous Systems by Freeze-Drying

AU - Wostry, Melvin

AU - Plappert, Hanna

AU - Grohganz, Holger

PY - 2020

Y1 - 2020

N2 - Freeze-drying was evaluated as a production technique for co-amorphous systems of a poorly water-soluble drug. Naproxen was freeze-dried together with arginine and lysine as co-former. To increase the solubility of naproxen in the starting solution, the applicability of five surfactants was investigated, namely sodium dodecyl sulfate, pluronic F-127, polyoxyethylene (40) stearate, tween 20 and TPGS 1000. The influence of the surfactant type, surfactant concentration and total solid content to be freeze-dried on the solid state of the sample was investigated. X-ray powder diffraction and differential scanning calorimetry showed that the majority of systems formed co-amorphous one-phase systems. However, at higher surfactant concentrations, and depending on the surfactant type, surfactant reflections were observed in the XRPD analysis upon production. Crystallization of both naproxen and amino acid occurred from some combinations under storage. In conclusion, freeze-drying was shown to be a feasible technique for the production of a selection of co-amorphous drug-amino acid formulations.

AB - Freeze-drying was evaluated as a production technique for co-amorphous systems of a poorly water-soluble drug. Naproxen was freeze-dried together with arginine and lysine as co-former. To increase the solubility of naproxen in the starting solution, the applicability of five surfactants was investigated, namely sodium dodecyl sulfate, pluronic F-127, polyoxyethylene (40) stearate, tween 20 and TPGS 1000. The influence of the surfactant type, surfactant concentration and total solid content to be freeze-dried on the solid state of the sample was investigated. X-ray powder diffraction and differential scanning calorimetry showed that the majority of systems formed co-amorphous one-phase systems. However, at higher surfactant concentrations, and depending on the surfactant type, surfactant reflections were observed in the XRPD analysis upon production. Crystallization of both naproxen and amino acid occurred from some combinations under storage. In conclusion, freeze-drying was shown to be a feasible technique for the production of a selection of co-amorphous drug-amino acid formulations.

KW - co-amorphous

KW - freeze-drying

KW - surfactant

KW - WATER-SOLUBLE DRUGS

KW - AMINO-ACIDS

KW - ENHANCED DISSOLUTION

KW - BINARY-SYSTEMS

KW - STABILITY

KW - FORMULATIONS

KW - SOLUBILITY

KW - SACCHARIN

KW - BEHAVIOR

KW - IMPROVE

U2 - 10.3390/pharmaceutics12100941

DO - 10.3390/pharmaceutics12100941

M3 - Journal article

C2 - 33008124

VL - 12

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 10

M1 - 941

ER -

ID: 251313067