Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood
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Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood. / Kristensen, Susanne Lund; Ramlau-Hansen, Cecilia Høst; Ernst, Erik; Olsen, Sjurdur Frodi; Bonde, Jens Peter; Vested, Anne; Halldorsson, Thorhallur Ingi; Rantakokko, Panu; Kiviranta, Hannu; Toft, Gunnar.
In: Environment International, Vol. 92-93, 2016, p. 366-72.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prenatal exposure to persistent organochlorine pollutants and female reproductive function in young adulthood
AU - Kristensen, Susanne Lund
AU - Ramlau-Hansen, Cecilia Høst
AU - Ernst, Erik
AU - Olsen, Sjurdur Frodi
AU - Bonde, Jens Peter
AU - Vested, Anne
AU - Halldorsson, Thorhallur Ingi
AU - Rantakokko, Panu
AU - Kiviranta, Hannu
AU - Toft, Gunnar
N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.
PY - 2016
Y1 - 2016
N2 - BACKGROUND: The biopersistent organochlorine pollutants dichlorodiphenyldichloroethylene (p,p'-DDE), hexachlorobenzene (HCB) and polychlorinated biphenyls (PCBs) can be detected in humans worldwide. The chemicals can cross the placenta and may interfere with endogenous hormonal homeostasis.OBJECTIVES: To investigate effects on female reproduction following intrauterine exposure to selected biopersistent organochlorines.METHODS: We used data from a Danish pregnancy cohort with follow-up on 436 eligible daughters at approximately 20years of age. Information on age of menarche (n=335), menstrual cycle length (n=230) and serum concentrations of reproductive hormones (n=243) was obtained. Number of antral follicles was counted by vaginal ultrasound (n=147). Of 244 daughters who attended clinical examination, 170 used hormonal contraceptives and 74 were non-users. Concentrations of p,p'-DDE, HCB and six PCB congeners were analysed in maternal serum samples obtained in pregnancy week 30.RESULTS: Age of menarche and menstrual cycle length were found not to be statistically significant associated with prenatal organochlorine exposure. Among non-users of hormonal contraceptives with information on antral follicle number (n=43), daughters exposed to the highest tertile of p,p'-DDE had 28% (95% confidence interval (95% CI): 5; 46%) lower follicle number compared to the low-level exposed reference group. Those exposed to medium and higher levels of HCB had 30% (95% CI: 5; 48%) and 28% (95% CI: 7; 44%) lower follicle number compared to the reference group. Furthermore, maternal serum HCB concentrations were inversely associated with free androgen index among non-users of hormonal contraceptives (n=73). These associations were not found in users of hormonal contraceptives.CONCLUSIONS: Among non-users of hormonal contraceptives, we found indications of adverse long-term effects on female reproduction following prenatal exposure to biopersistent organochlorines. These findings may have wide implications for public health as intrauterine exposure occurs worldwide.
AB - BACKGROUND: The biopersistent organochlorine pollutants dichlorodiphenyldichloroethylene (p,p'-DDE), hexachlorobenzene (HCB) and polychlorinated biphenyls (PCBs) can be detected in humans worldwide. The chemicals can cross the placenta and may interfere with endogenous hormonal homeostasis.OBJECTIVES: To investigate effects on female reproduction following intrauterine exposure to selected biopersistent organochlorines.METHODS: We used data from a Danish pregnancy cohort with follow-up on 436 eligible daughters at approximately 20years of age. Information on age of menarche (n=335), menstrual cycle length (n=230) and serum concentrations of reproductive hormones (n=243) was obtained. Number of antral follicles was counted by vaginal ultrasound (n=147). Of 244 daughters who attended clinical examination, 170 used hormonal contraceptives and 74 were non-users. Concentrations of p,p'-DDE, HCB and six PCB congeners were analysed in maternal serum samples obtained in pregnancy week 30.RESULTS: Age of menarche and menstrual cycle length were found not to be statistically significant associated with prenatal organochlorine exposure. Among non-users of hormonal contraceptives with information on antral follicle number (n=43), daughters exposed to the highest tertile of p,p'-DDE had 28% (95% confidence interval (95% CI): 5; 46%) lower follicle number compared to the low-level exposed reference group. Those exposed to medium and higher levels of HCB had 30% (95% CI: 5; 48%) and 28% (95% CI: 7; 44%) lower follicle number compared to the reference group. Furthermore, maternal serum HCB concentrations were inversely associated with free androgen index among non-users of hormonal contraceptives (n=73). These associations were not found in users of hormonal contraceptives.CONCLUSIONS: Among non-users of hormonal contraceptives, we found indications of adverse long-term effects on female reproduction following prenatal exposure to biopersistent organochlorines. These findings may have wide implications for public health as intrauterine exposure occurs worldwide.
KW - Adult
KW - Cohort Studies
KW - Denmark
KW - Environmental Exposure
KW - Environmental Pollutants/adverse effects
KW - Female
KW - Fetal Development
KW - Gestational Age
KW - Humans
KW - Hydrocarbons, Chlorinated/adverse effects
KW - Menarche
KW - Placenta/chemistry
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Reproduction
KW - Young Adult
U2 - 10.1016/j.envint.2016.04.024
DO - 10.1016/j.envint.2016.04.024
M3 - Journal article
C2 - 27132162
VL - 92-93
SP - 366
EP - 372
JO - Environment international
JF - Environment international
SN - 0160-4120
ER -
ID: 306897366