Potassium Channels in the Heart

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or KCa2), inwardly rectifying potassium channels (Kir), two-pore-domain potassium channels (K2P), and voltage-gated potassium channels (KV). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.

Original languageEnglish
Title of host publicationCardiac and Vascular Biology
Number of pages29
PublisherSpringer Science and Business Media Deutschland GmbH
Publication date2018
Pages47-75
DOIs
Publication statusPublished - 2018
SeriesCardiac and Vascular Biology
Volume6
ISSN2509-7830

Bibliographical note

Publisher Copyright:
© 2018, Springer International Publishing AG, part of Springer Nature.

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