Potassium Channels in the Heart
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or KCa2), inwardly rectifying potassium channels (Kir), two-pore-domain potassium channels (K2P), and voltage-gated potassium channels (KV). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.
|Title of host publication||Channelopathies in Heart Disease|
|Number of pages||29|
|Publication status||Published - 2018|
|Series||Cardiac and Vascular Biology|
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