Postpartum and non-postpartum depression

Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Postpartum and non-postpartum depression : a population-based matched case-control study comparing polygenic risk scores for severe mental disorders. / Munk-Olsen, Trine; Di Florio, Arianna; Madsen, Kathrine B.; Albiñana, Clara; Mægbæk, Merete L.; Bergink, Veerle; Frøkjær, Vibe G.; Agerbo, Esben; Vilhjálmsson, Bjarni J.; Werge, Thomas; Nordentoft, Merete; Hougaard, David M.; Børglum, Anders D.; Mors, Ole; Mortensen, Preben Bo; Liu, Xiaoqin.

In: Translational Psychiatry, Vol. 13, No. 1, 346, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Munk-Olsen, T, Di Florio, A, Madsen, KB, Albiñana, C, Mægbæk, ML, Bergink, V, Frøkjær, VG, Agerbo, E, Vilhjálmsson, BJ, Werge, T, Nordentoft, M, Hougaard, DM, Børglum, AD, Mors, O, Mortensen, PB & Liu, X 2023, 'Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders', Translational Psychiatry, vol. 13, no. 1, 346. https://doi.org/10.1038/s41398-023-02649-2

APA

Munk-Olsen, T., Di Florio, A., Madsen, K. B., Albiñana, C., Mægbæk, M. L., Bergink, V., Frøkjær, V. G., Agerbo, E., Vilhjálmsson, B. J., Werge, T., Nordentoft, M., Hougaard, D. M., Børglum, A. D., Mors, O., Mortensen, P. B., & Liu, X. (2023). Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders. Translational Psychiatry, 13(1), [346]. https://doi.org/10.1038/s41398-023-02649-2

Vancouver

Munk-Olsen T, Di Florio A, Madsen KB, Albiñana C, Mægbæk ML, Bergink V et al. Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders. Translational Psychiatry. 2023;13(1). 346. https://doi.org/10.1038/s41398-023-02649-2

Author

Munk-Olsen, Trine ; Di Florio, Arianna ; Madsen, Kathrine B. ; Albiñana, Clara ; Mægbæk, Merete L. ; Bergink, Veerle ; Frøkjær, Vibe G. ; Agerbo, Esben ; Vilhjálmsson, Bjarni J. ; Werge, Thomas ; Nordentoft, Merete ; Hougaard, David M. ; Børglum, Anders D. ; Mors, Ole ; Mortensen, Preben Bo ; Liu, Xiaoqin. / Postpartum and non-postpartum depression : a population-based matched case-control study comparing polygenic risk scores for severe mental disorders. In: Translational Psychiatry. 2023 ; Vol. 13, No. 1.

Bibtex

@article{eb10a6f5ebfa41d5baed0ea9000b2d15,

title = "Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders",

abstract = "It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark. We identified 333 women with first-onset postpartum depression (PPD group), who were matched with 993 women with first-onset depression diagnosed outside of postpartum (MDD group), and 999 female population controls. Data on genetics and depressive disorders were retrieved from neonatal biobanks and the Psychiatric Central Research Register. PGSs were calculated from both individual-level genetic data and meta-analysis summary statistics from the Psychiatric Genomics Consortium. Conditional logistic regression was used to calculate the odds ratio (OR), accounting for the selection-related reproductive behavior. After adjustment for covariates, higher PGSs for severe mental disorders were associated with increased ORs of both PPD and MDD. Compared with MDD cases, MDD PGS and attention-deficit/hyperactivity disorder PGS were marginally but not statistically higher for PPD cases, with the OR of PPD versus MDD being 1.12 (95% CI: 0.97–1.29) and 1.11 (0.97–1.27) per-standard deviation increase, respectively. The ORs of PPD versus MDD did not statistically differ by PGSs of bipolar disorder, schizophrenia, or autism spectrum disorder. Our findings suggest that relying on PGS data, there was no clear evidence of distinct genetic make-up of women with depression occurring during or outside postpartum, after taking the selection-related reproductive behavior into account.",

author = "Trine Munk-Olsen and {Di Florio}, Arianna and Madsen, {Kathrine B.} and Clara Albi{\~n}ana and M{\ae}gb{\ae}k, {Merete L.} and Veerle Bergink and Fr{\o}kj{\ae}r, {Vibe G.} and Esben Agerbo and Vilhj{\'a}lmsson, {Bjarni J.} and Thomas Werge and Merete Nordentoft and Hougaard, {David M.} and B{\o}rglum, {Anders D.} and Ole Mors and Mortensen, {Preben Bo} and Xiaoqin Liu",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

doi = "10.1038/s41398-023-02649-2",

language = "English",

volume = "13",

journal = "Translational Psychiatry",

issn = "2158-3188",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - Postpartum and non-postpartum depression

T2 - a population-based matched case-control study comparing polygenic risk scores for severe mental disorders

AU - Munk-Olsen, Trine

AU - Di Florio, Arianna

AU - Madsen, Kathrine B.

AU - Albiñana, Clara

AU - Mægbæk, Merete L.

AU - Bergink, Veerle

AU - Frøkjær, Vibe G.

AU - Agerbo, Esben

AU - Vilhjálmsson, Bjarni J.

AU - Werge, Thomas

AU - Nordentoft, Merete

AU - Hougaard, David M.

AU - Børglum, Anders D.

AU - Mors, Ole

AU - Mortensen, Preben Bo

AU - Liu, Xiaoqin

PY - 2023

Y1 - 2023

N2 - It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark. We identified 333 women with first-onset postpartum depression (PPD group), who were matched with 993 women with first-onset depression diagnosed outside of postpartum (MDD group), and 999 female population controls. Data on genetics and depressive disorders were retrieved from neonatal biobanks and the Psychiatric Central Research Register. PGSs were calculated from both individual-level genetic data and meta-analysis summary statistics from the Psychiatric Genomics Consortium. Conditional logistic regression was used to calculate the odds ratio (OR), accounting for the selection-related reproductive behavior. After adjustment for covariates, higher PGSs for severe mental disorders were associated with increased ORs of both PPD and MDD. Compared with MDD cases, MDD PGS and attention-deficit/hyperactivity disorder PGS were marginally but not statistically higher for PPD cases, with the OR of PPD versus MDD being 1.12 (95% CI: 0.97–1.29) and 1.11 (0.97–1.27) per-standard deviation increase, respectively. The ORs of PPD versus MDD did not statistically differ by PGSs of bipolar disorder, schizophrenia, or autism spectrum disorder. Our findings suggest that relying on PGS data, there was no clear evidence of distinct genetic make-up of women with depression occurring during or outside postpartum, after taking the selection-related reproductive behavior into account.

AB - It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disorders differ between PPD cases and MDD cases in a nested case-control study of 50,057 women born from 1981 to 1997 in the iPSYCH2015 sample in Demark. We identified 333 women with first-onset postpartum depression (PPD group), who were matched with 993 women with first-onset depression diagnosed outside of postpartum (MDD group), and 999 female population controls. Data on genetics and depressive disorders were retrieved from neonatal biobanks and the Psychiatric Central Research Register. PGSs were calculated from both individual-level genetic data and meta-analysis summary statistics from the Psychiatric Genomics Consortium. Conditional logistic regression was used to calculate the odds ratio (OR), accounting for the selection-related reproductive behavior. After adjustment for covariates, higher PGSs for severe mental disorders were associated with increased ORs of both PPD and MDD. Compared with MDD cases, MDD PGS and attention-deficit/hyperactivity disorder PGS were marginally but not statistically higher for PPD cases, with the OR of PPD versus MDD being 1.12 (95% CI: 0.97–1.29) and 1.11 (0.97–1.27) per-standard deviation increase, respectively. The ORs of PPD versus MDD did not statistically differ by PGSs of bipolar disorder, schizophrenia, or autism spectrum disorder. Our findings suggest that relying on PGS data, there was no clear evidence of distinct genetic make-up of women with depression occurring during or outside postpartum, after taking the selection-related reproductive behavior into account.

U2 - 10.1038/s41398-023-02649-2

DO - 10.1038/s41398-023-02649-2

M3 - Journal article

C2 - 37953300

AN - SCOPUS:85176457984

VL - 13

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 1

M1 - 346

ER -

ID: 373871791