Postoperative morbidity among symptom-free alcohol misusers

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Postoperative morbidity among symptom-free alcohol misusers. / Tønnesen, H; Petersen, K R; Højgaard, L; Stokholm, K H; Nielsen, H J; Knigge, U; Kehlet, H.

In: Lancet Oncology, Vol. 340, No. 8815, 08.08.1992, p. 334-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tønnesen, H, Petersen, KR, Højgaard, L, Stokholm, KH, Nielsen, HJ, Knigge, U & Kehlet, H 1992, 'Postoperative morbidity among symptom-free alcohol misusers', Lancet Oncology, vol. 340, no. 8815, pp. 334-7.

APA

Tønnesen, H., Petersen, K. R., Højgaard, L., Stokholm, K. H., Nielsen, H. J., Knigge, U., & Kehlet, H. (1992). Postoperative morbidity among symptom-free alcohol misusers. Lancet Oncology, 340(8815), 334-7.

Vancouver

Tønnesen H, Petersen KR, Højgaard L, Stokholm KH, Nielsen HJ, Knigge U et al. Postoperative morbidity among symptom-free alcohol misusers. Lancet Oncology. 1992 Aug 8;340(8815):334-7.

Author

Tønnesen, H ; Petersen, K R ; Højgaard, L ; Stokholm, K H ; Nielsen, H J ; Knigge, U ; Kehlet, H. / Postoperative morbidity among symptom-free alcohol misusers. In: Lancet Oncology. 1992 ; Vol. 340, No. 8815. pp. 334-7.

Bibtex

@article{3233cc61b65f48dcba60112c0d48b8de,
title = "Postoperative morbidity among symptom-free alcohol misusers",
abstract = "Retrospective studies suggest that there is an increased postoperative morbidity among alcohol misusers. We have prospectively studied the risk of alcohol intake among patients undergoing surgery. We investigated 15 symptom-free subjects who required colorectal surgery and who were drinking at least 60 g of alcohol per day. These patients were matched for sex, nutrition, age, weight, cardiovascular and pulmonary disease, diagnosis, anaesthesia, and surgery to 15 control subjects who were consuming below 25 g of alcohol daily. Those drinking at least 60 g of alcohol per day developed more postoperative complications than controls (67% vs 20%, p less than 0.05) and hospital stay was prolonged (20 vs 12 days, p less than 0.05). Preoperatively, alcohol misusers had reduced left ventricular ejection fraction (median, 54% vs 68%, p less than 0.01). Delayed hypersensitivity responses were smaller in the alcohol group before (53 mm2 vs 78 mm2, p less than 0.05) and after (18 mm2 vs 55 mm2, p less than 0.01) surgery. Alcohol misusers had longer bleeding times during the first postoperative week (p less than 0.01). Surgical stress responses, as assessed by changes in plasma cortisol and catecholamines, were higher among alcoholics (p less than 0.05). Postoperative morbidity is increased in symptom-free alcohol misusers. The mechanism is probably subclinical cardiac insufficiency, immunosuppression, and decreased haemostatic function. Preoperative alcohol consumption may be a more important risk factor than previously thought.",
keywords = "Aged, Aged, 80 and over, Alcoholism, Bleeding Time, Blood Coagulation Disorders, Blood Glucose, Blood Pressure, Cardiac Output, Low, Catecholamines, Colonic Diseases, Denmark, Heart Rate, Hospitals, University, Humans, Hydrocortisone, Immunologic Deficiency Syndromes, Infection, Length of Stay, Male, Matched-Pair Analysis, Middle Aged, Nursing Care, Postoperative Complications, Prospective Studies, Rectal Diseases, Risk Factors, Stroke Volume, Journal Article, Research Support, Non-U.S. Gov't",
author = "H T{\o}nnesen and Petersen, {K R} and L H{\o}jgaard and Stokholm, {K H} and Nielsen, {H J} and U Knigge and H Kehlet",
year = "1992",
month = aug,
day = "8",
language = "English",
volume = "340",
pages = "334--7",
journal = "The Lancet Oncology",
issn = "1470-2045",
publisher = "TheLancet Publishing Group",
number = "8815",

}

RIS

TY - JOUR

T1 - Postoperative morbidity among symptom-free alcohol misusers

AU - Tønnesen, H

AU - Petersen, K R

AU - Højgaard, L

AU - Stokholm, K H

AU - Nielsen, H J

AU - Knigge, U

AU - Kehlet, H

PY - 1992/8/8

Y1 - 1992/8/8

N2 - Retrospective studies suggest that there is an increased postoperative morbidity among alcohol misusers. We have prospectively studied the risk of alcohol intake among patients undergoing surgery. We investigated 15 symptom-free subjects who required colorectal surgery and who were drinking at least 60 g of alcohol per day. These patients were matched for sex, nutrition, age, weight, cardiovascular and pulmonary disease, diagnosis, anaesthesia, and surgery to 15 control subjects who were consuming below 25 g of alcohol daily. Those drinking at least 60 g of alcohol per day developed more postoperative complications than controls (67% vs 20%, p less than 0.05) and hospital stay was prolonged (20 vs 12 days, p less than 0.05). Preoperatively, alcohol misusers had reduced left ventricular ejection fraction (median, 54% vs 68%, p less than 0.01). Delayed hypersensitivity responses were smaller in the alcohol group before (53 mm2 vs 78 mm2, p less than 0.05) and after (18 mm2 vs 55 mm2, p less than 0.01) surgery. Alcohol misusers had longer bleeding times during the first postoperative week (p less than 0.01). Surgical stress responses, as assessed by changes in plasma cortisol and catecholamines, were higher among alcoholics (p less than 0.05). Postoperative morbidity is increased in symptom-free alcohol misusers. The mechanism is probably subclinical cardiac insufficiency, immunosuppression, and decreased haemostatic function. Preoperative alcohol consumption may be a more important risk factor than previously thought.

AB - Retrospective studies suggest that there is an increased postoperative morbidity among alcohol misusers. We have prospectively studied the risk of alcohol intake among patients undergoing surgery. We investigated 15 symptom-free subjects who required colorectal surgery and who were drinking at least 60 g of alcohol per day. These patients were matched for sex, nutrition, age, weight, cardiovascular and pulmonary disease, diagnosis, anaesthesia, and surgery to 15 control subjects who were consuming below 25 g of alcohol daily. Those drinking at least 60 g of alcohol per day developed more postoperative complications than controls (67% vs 20%, p less than 0.05) and hospital stay was prolonged (20 vs 12 days, p less than 0.05). Preoperatively, alcohol misusers had reduced left ventricular ejection fraction (median, 54% vs 68%, p less than 0.01). Delayed hypersensitivity responses were smaller in the alcohol group before (53 mm2 vs 78 mm2, p less than 0.05) and after (18 mm2 vs 55 mm2, p less than 0.01) surgery. Alcohol misusers had longer bleeding times during the first postoperative week (p less than 0.01). Surgical stress responses, as assessed by changes in plasma cortisol and catecholamines, were higher among alcoholics (p less than 0.05). Postoperative morbidity is increased in symptom-free alcohol misusers. The mechanism is probably subclinical cardiac insufficiency, immunosuppression, and decreased haemostatic function. Preoperative alcohol consumption may be a more important risk factor than previously thought.

KW - Aged

KW - Aged, 80 and over

KW - Alcoholism

KW - Bleeding Time

KW - Blood Coagulation Disorders

KW - Blood Glucose

KW - Blood Pressure

KW - Cardiac Output, Low

KW - Catecholamines

KW - Colonic Diseases

KW - Denmark

KW - Heart Rate

KW - Hospitals, University

KW - Humans

KW - Hydrocortisone

KW - Immunologic Deficiency Syndromes

KW - Infection

KW - Length of Stay

KW - Male

KW - Matched-Pair Analysis

KW - Middle Aged

KW - Nursing Care

KW - Postoperative Complications

KW - Prospective Studies

KW - Rectal Diseases

KW - Risk Factors

KW - Stroke Volume

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 1353805

VL - 340

SP - 334

EP - 337

JO - The Lancet Oncology

JF - The Lancet Oncology

SN - 1470-2045

IS - 8815

ER -

ID: 165884840