Postoperative Chronic Hypoparathyroidism and Quality of Life After Total Thyroidectomy
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Postoperative Chronic Hypoparathyroidism and Quality of Life After Total Thyroidectomy. / Jørgensen, Camilla Uhre; Homøe, Preben; Dahl, Morten; Hitz, Mette Friberg.
In: JBMR Plus, Vol. 5, No. 4, e10479, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Postoperative Chronic Hypoparathyroidism and Quality of Life After Total Thyroidectomy
AU - Jørgensen, Camilla Uhre
AU - Homøe, Preben
AU - Dahl, Morten
AU - Hitz, Mette Friberg
PY - 2021
Y1 - 2021
N2 - Chronic hypoparathyroidism (HypoPT) is a common complication after total thyroidectomy and it impacts affected patients' quality of life (QoL). This study aimed to assess the QoL in patients with chronic HypoPT independently from their concurrent hypothyroidism and other comorbidities. For this purpose a follow-up study was performed, including 14 patients who developed chronic HypoPT after total thyroidectomy and 28 age- and sex-matched patients who had intact parathyroid function after total thyroidectomy. We used the RAND Short Form 36 Health Survey (SF-36) to compare the QoL between patients with or without chronic HypoPT. Chronic HypoPT patients had lower QoL scores in all domains of the RAND-SF-36 questionnaire and significant impairment in six of eight domains after adjustment for relevant confounders. They were more often operated because of a toxic diagnosis (p =.01), often being Graves disease. Additionally adjusting for surgical indications resulted in three of eight domains being significant affected. Chronic HypoPT is associated with significantly impairment of QoL, independently of the concurrent disease of hypothyroidism, comorbidities, and prospective values of TSH and serum (se)-ionized-Ca++. There is a need for more focus and better treatment of patients experiencing chronic HypoPT after surgery.
AB - Chronic hypoparathyroidism (HypoPT) is a common complication after total thyroidectomy and it impacts affected patients' quality of life (QoL). This study aimed to assess the QoL in patients with chronic HypoPT independently from their concurrent hypothyroidism and other comorbidities. For this purpose a follow-up study was performed, including 14 patients who developed chronic HypoPT after total thyroidectomy and 28 age- and sex-matched patients who had intact parathyroid function after total thyroidectomy. We used the RAND Short Form 36 Health Survey (SF-36) to compare the QoL between patients with or without chronic HypoPT. Chronic HypoPT patients had lower QoL scores in all domains of the RAND-SF-36 questionnaire and significant impairment in six of eight domains after adjustment for relevant confounders. They were more often operated because of a toxic diagnosis (p =.01), often being Graves disease. Additionally adjusting for surgical indications resulted in three of eight domains being significant affected. Chronic HypoPT is associated with significantly impairment of QoL, independently of the concurrent disease of hypothyroidism, comorbidities, and prospective values of TSH and serum (se)-ionized-Ca++. There is a need for more focus and better treatment of patients experiencing chronic HypoPT after surgery.
KW - CALCIUM
KW - PARATHYROIDEA
KW - QoL
KW - RAND-36
KW - THYROIDECTOMY
U2 - 10.1002/jbm4.10479
DO - 10.1002/jbm4.10479
M3 - Journal article
C2 - 33869995
AN - SCOPUS:85102517064
VL - 5
JO - JBMR Plus
JF - JBMR Plus
SN - 2473-4039
IS - 4
M1 - e10479
ER -
ID: 259054900