Positron Emission Tomography/Computed Tomography in the Staging and Treatment of Anal Cancer

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Positron Emission Tomography/Computed Tomography in the Staging and Treatment of Anal Cancer. / Sveistrup, Joen; Loft, Annika; Berthelsen, Anne Kiil; Henriksen, Birthe Merete; Nielsen, Michael Bachmann; Engelholm, Svend Aage.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 83, No. 1, 2012, p. 134-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sveistrup, J, Loft, A, Berthelsen, AK, Henriksen, BM, Nielsen, MB & Engelholm, SA 2012, 'Positron Emission Tomography/Computed Tomography in the Staging and Treatment of Anal Cancer', International Journal of Radiation Oncology, Biology, Physics, vol. 83, no. 1, pp. 134-41. https://doi.org/10.1016/j.ijrobp.2011.06.1955

APA

Sveistrup, J., Loft, A., Berthelsen, A. K., Henriksen, B. M., Nielsen, M. B., & Engelholm, S. A. (2012). Positron Emission Tomography/Computed Tomography in the Staging and Treatment of Anal Cancer. International Journal of Radiation Oncology, Biology, Physics, 83(1), 134-41. https://doi.org/10.1016/j.ijrobp.2011.06.1955

Vancouver

Sveistrup J, Loft A, Berthelsen AK, Henriksen BM, Nielsen MB, Engelholm SA. Positron Emission Tomography/Computed Tomography in the Staging and Treatment of Anal Cancer. International Journal of Radiation Oncology, Biology, Physics. 2012;83(1):134-41. https://doi.org/10.1016/j.ijrobp.2011.06.1955

Author

Sveistrup, Joen ; Loft, Annika ; Berthelsen, Anne Kiil ; Henriksen, Birthe Merete ; Nielsen, Michael Bachmann ; Engelholm, Svend Aage. / Positron Emission Tomography/Computed Tomography in the Staging and Treatment of Anal Cancer. In: International Journal of Radiation Oncology, Biology, Physics. 2012 ; Vol. 83, No. 1. pp. 134-41.

Bibtex

@article{425276641edc430d9114d5bb2bcbbffe,

title = "Positron Emission Tomography/Computed Tomography in the Staging and Treatment of Anal Cancer",

abstract = "PURPOSE: This study was intended to determine the role of PET/CT in the staging of anal cancer as a supplement to three-dimensional transanal ultrasound (TAUS) and inguinal ultrasound (US). The impact of the PET/CT on the initial stage and treatment plan proposed by TAUS/US was assessed. METHODS AND MATERIALS: Ninety-five (95) patients referred to our clinic between July 1, 2005, and December 31, 2009, were retrospectively reviewed. All patients had biopsy-proven primary squamous cell cancer of the anal canal. There were 65 females (68%) and 30 males (32%), and the median age was 58 years (range, 35-88 years). Six (6%) of the patients were HIV positive. All patients were staged with TAUS/US and PET/CT. RESULTS: Twenty-eight (28) patients were diagnosed with suspicious perirectal node metastases. TAUS visualized 24 of these, whereas PET/CT detected 15. Suspicious inguinal nodes were visualized on either US or PET/CT in 41 patients. Seventeen (17) of these had confirmed malignant disease on biopsy, and 15 had confirmed benign disease. All 17 patients (100%) with malignant inguinal nodes were diagnosed by PET/CT, whereas US identified 16 (94%). Ten patients were diagnosed with suspicious inguinal nodes on PET/CT that had not been seen on US. One of these was malignant, three were benign, and six were not biopsied. PET/CT diagnosed eight metastatic sites, whereas TAUS/US diagnosed three. PET/CT discovered three of the five synchronous cancers seen in this study. PET/CT upstaged the disease in 14% of the cases and changed the treatment plan proposed by TAUS/US in 17%. CONCLUSION: PET/CT has great potential influence on the staging and treatment of anal cancer. TAUS is important in the staging of the primary tumor and N1-stage, whereas PET/CT seems necessary for the N2/3-stage, the M-stage and synchronous cancers.",

author = "Joen Sveistrup and Annika Loft and Berthelsen, {Anne Kiil} and Henriksen, {Birthe Merete} and Nielsen, {Michael Bachmann} and Engelholm, {Svend Aage}",

year = "2012",

doi = "10.1016/j.ijrobp.2011.06.1955",

language = "English",

volume = "83",

pages = "134--41",

journal = "International Journal of Radiation Oncology, Biology, Physics",

issn = "0360-3016",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Positron Emission Tomography/Computed Tomography in the Staging and Treatment of Anal Cancer

AU - Sveistrup, Joen

AU - Loft, Annika

AU - Berthelsen, Anne Kiil

AU - Henriksen, Birthe Merete

AU - Nielsen, Michael Bachmann

AU - Engelholm, Svend Aage

PY - 2012

Y1 - 2012

N2 - PURPOSE: This study was intended to determine the role of PET/CT in the staging of anal cancer as a supplement to three-dimensional transanal ultrasound (TAUS) and inguinal ultrasound (US). The impact of the PET/CT on the initial stage and treatment plan proposed by TAUS/US was assessed. METHODS AND MATERIALS: Ninety-five (95) patients referred to our clinic between July 1, 2005, and December 31, 2009, were retrospectively reviewed. All patients had biopsy-proven primary squamous cell cancer of the anal canal. There were 65 females (68%) and 30 males (32%), and the median age was 58 years (range, 35-88 years). Six (6%) of the patients were HIV positive. All patients were staged with TAUS/US and PET/CT. RESULTS: Twenty-eight (28) patients were diagnosed with suspicious perirectal node metastases. TAUS visualized 24 of these, whereas PET/CT detected 15. Suspicious inguinal nodes were visualized on either US or PET/CT in 41 patients. Seventeen (17) of these had confirmed malignant disease on biopsy, and 15 had confirmed benign disease. All 17 patients (100%) with malignant inguinal nodes were diagnosed by PET/CT, whereas US identified 16 (94%). Ten patients were diagnosed with suspicious inguinal nodes on PET/CT that had not been seen on US. One of these was malignant, three were benign, and six were not biopsied. PET/CT diagnosed eight metastatic sites, whereas TAUS/US diagnosed three. PET/CT discovered three of the five synchronous cancers seen in this study. PET/CT upstaged the disease in 14% of the cases and changed the treatment plan proposed by TAUS/US in 17%. CONCLUSION: PET/CT has great potential influence on the staging and treatment of anal cancer. TAUS is important in the staging of the primary tumor and N1-stage, whereas PET/CT seems necessary for the N2/3-stage, the M-stage and synchronous cancers.

AB - PURPOSE: This study was intended to determine the role of PET/CT in the staging of anal cancer as a supplement to three-dimensional transanal ultrasound (TAUS) and inguinal ultrasound (US). The impact of the PET/CT on the initial stage and treatment plan proposed by TAUS/US was assessed. METHODS AND MATERIALS: Ninety-five (95) patients referred to our clinic between July 1, 2005, and December 31, 2009, were retrospectively reviewed. All patients had biopsy-proven primary squamous cell cancer of the anal canal. There were 65 females (68%) and 30 males (32%), and the median age was 58 years (range, 35-88 years). Six (6%) of the patients were HIV positive. All patients were staged with TAUS/US and PET/CT. RESULTS: Twenty-eight (28) patients were diagnosed with suspicious perirectal node metastases. TAUS visualized 24 of these, whereas PET/CT detected 15. Suspicious inguinal nodes were visualized on either US or PET/CT in 41 patients. Seventeen (17) of these had confirmed malignant disease on biopsy, and 15 had confirmed benign disease. All 17 patients (100%) with malignant inguinal nodes were diagnosed by PET/CT, whereas US identified 16 (94%). Ten patients were diagnosed with suspicious inguinal nodes on PET/CT that had not been seen on US. One of these was malignant, three were benign, and six were not biopsied. PET/CT diagnosed eight metastatic sites, whereas TAUS/US diagnosed three. PET/CT discovered three of the five synchronous cancers seen in this study. PET/CT upstaged the disease in 14% of the cases and changed the treatment plan proposed by TAUS/US in 17%. CONCLUSION: PET/CT has great potential influence on the staging and treatment of anal cancer. TAUS is important in the staging of the primary tumor and N1-stage, whereas PET/CT seems necessary for the N2/3-stage, the M-stage and synchronous cancers.

U2 - 10.1016/j.ijrobp.2011.06.1955

DO - 10.1016/j.ijrobp.2011.06.1955

M3 - Journal article

VL - 83

SP - 134

EP - 141

JO - International Journal of Radiation Oncology, Biology, Physics

JF - International Journal of Radiation Oncology, Biology, Physics

SN - 0360-3016

IS - 1

ER -

ID: 40150465