Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy. / Overgaard, Anne Julie; Hansen, Henning Gram; Lajer, Maria; Pedersen, Lykke; Tarnow, Lise; Rossing, Peter; McGuire, James N.; Pociot, Flemming.

In: Proteome Science, Vol. 8, 2010, p. 4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Overgaard, AJ, Hansen, HG, Lajer, M, Pedersen, L, Tarnow, L, Rossing, P, McGuire, JN & Pociot, F 2010, 'Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy', Proteome Science, vol. 8, pp. 4. https://doi.org/10.1186/1477-5956-8-4

APA

Overgaard, A. J., Hansen, H. G., Lajer, M., Pedersen, L., Tarnow, L., Rossing, P., McGuire, J. N., & Pociot, F. (2010). Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy. Proteome Science, 8, 4. https://doi.org/10.1186/1477-5956-8-4

Vancouver

Overgaard AJ, Hansen HG, Lajer M, Pedersen L, Tarnow L, Rossing P et al. Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy. Proteome Science. 2010;8:4. https://doi.org/10.1186/1477-5956-8-4

Author

Overgaard, Anne Julie ; Hansen, Henning Gram ; Lajer, Maria ; Pedersen, Lykke ; Tarnow, Lise ; Rossing, Peter ; McGuire, James N. ; Pociot, Flemming. / Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy. In: Proteome Science. 2010 ; Vol. 8. pp. 4.

Bibtex

@article{8318962cbe5946f7afd0cf25a7e6d940,
title = "Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy",
abstract = "As part of a clinical proteomics program focused on diabetes and its complications we are looking for new and better protein biomarkers for diabetic nephropathy. The search for new and better biomarkers for diabetic nephropathy has, with a few exceptions, previously focused on either hypothesis-driven studies or urinary based investigations. To date only two studies have investigated the proteome of blood in search for new biomarkers, and these studies were conducted in sera from patients with type 2 diabetes. This is the first reported in depth proteomic study where plasma from type 1 diabetic patients was investigated with the goal of finding improved candidate biomarkers to predict diabetic nephropathy. In order to reach lower concentration proteins in plasma a pre-fractionation step, either hexapeptide bead-based libraries or anion exchange chromatography, was performed prior to surface enhanced laser desorption/ionization time-of-flight mass spectrometry analysis.",
author = "Overgaard, {Anne Julie} and Hansen, {Henning Gram} and Maria Lajer and Lykke Pedersen and Lise Tarnow and Peter Rossing and McGuire, {James N.} and Flemming Pociot",
year = "2010",
doi = "10.1186/1477-5956-8-4",
language = "English",
volume = "8",
pages = "4",
journal = "Proteome Science",
issn = "1477-5956",
publisher = "BioMed Central",

}

RIS

TY - JOUR

T1 - Plasma proteome analysis of patients with type 1 diabetes with diabetic nephropathy

AU - Overgaard, Anne Julie

AU - Hansen, Henning Gram

AU - Lajer, Maria

AU - Pedersen, Lykke

AU - Tarnow, Lise

AU - Rossing, Peter

AU - McGuire, James N.

AU - Pociot, Flemming

PY - 2010

Y1 - 2010

N2 - As part of a clinical proteomics program focused on diabetes and its complications we are looking for new and better protein biomarkers for diabetic nephropathy. The search for new and better biomarkers for diabetic nephropathy has, with a few exceptions, previously focused on either hypothesis-driven studies or urinary based investigations. To date only two studies have investigated the proteome of blood in search for new biomarkers, and these studies were conducted in sera from patients with type 2 diabetes. This is the first reported in depth proteomic study where plasma from type 1 diabetic patients was investigated with the goal of finding improved candidate biomarkers to predict diabetic nephropathy. In order to reach lower concentration proteins in plasma a pre-fractionation step, either hexapeptide bead-based libraries or anion exchange chromatography, was performed prior to surface enhanced laser desorption/ionization time-of-flight mass spectrometry analysis.

AB - As part of a clinical proteomics program focused on diabetes and its complications we are looking for new and better protein biomarkers for diabetic nephropathy. The search for new and better biomarkers for diabetic nephropathy has, with a few exceptions, previously focused on either hypothesis-driven studies or urinary based investigations. To date only two studies have investigated the proteome of blood in search for new biomarkers, and these studies were conducted in sera from patients with type 2 diabetes. This is the first reported in depth proteomic study where plasma from type 1 diabetic patients was investigated with the goal of finding improved candidate biomarkers to predict diabetic nephropathy. In order to reach lower concentration proteins in plasma a pre-fractionation step, either hexapeptide bead-based libraries or anion exchange chromatography, was performed prior to surface enhanced laser desorption/ionization time-of-flight mass spectrometry analysis.

U2 - 10.1186/1477-5956-8-4

DO - 10.1186/1477-5956-8-4

M3 - Journal article

C2 - 20205888

VL - 8

SP - 4

JO - Proteome Science

JF - Proteome Science

SN - 1477-5956

ER -

ID: 32671884