Pharos 2023: an integrated resource for the understudied human proteome

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Pharos 2023 : an integrated resource for the understudied human proteome. / Kelleher, Keith J.; Sheils, Timothy K.; Mathias, Stephen L.; Yang, Jeremy J.; Metzger, Vincent T.; Siramshetty, Vishal B.; Nguyen, Dac-Trung; Jensen, Lars Juhl; Vidovic, Dusica; Schurer, Stephan C.; Holmes, Jayme; Sharma, Karlie R.; Pillai, Ajay; Bologa, Cristian G.; Edwards, Jeremy S.; Mathe, Ewy A.; Oprea, Tudor.

In: Nucleic Acids Research, Vol. 51, No. D1, gkac1033, 2023, p. D1405-D1416.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kelleher, KJ, Sheils, TK, Mathias, SL, Yang, JJ, Metzger, VT, Siramshetty, VB, Nguyen, D-T, Jensen, LJ, Vidovic, D, Schurer, SC, Holmes, J, Sharma, KR, Pillai, A, Bologa, CG, Edwards, JS, Mathe, EA & Oprea, T 2023, 'Pharos 2023: an integrated resource for the understudied human proteome', Nucleic Acids Research, vol. 51, no. D1, gkac1033, pp. D1405-D1416. https://doi.org/10.1093/nar/gkac1033

APA

Kelleher, K. J., Sheils, T. K., Mathias, S. L., Yang, J. J., Metzger, V. T., Siramshetty, V. B., Nguyen, D-T., Jensen, L. J., Vidovic, D., Schurer, S. C., Holmes, J., Sharma, K. R., Pillai, A., Bologa, C. G., Edwards, J. S., Mathe, E. A., & Oprea, T. (2023). Pharos 2023: an integrated resource for the understudied human proteome. Nucleic Acids Research, 51(D1), D1405-D1416. [gkac1033]. https://doi.org/10.1093/nar/gkac1033

Vancouver

Kelleher KJ, Sheils TK, Mathias SL, Yang JJ, Metzger VT, Siramshetty VB et al. Pharos 2023: an integrated resource for the understudied human proteome. Nucleic Acids Research. 2023;51(D1):D1405-D1416. gkac1033. https://doi.org/10.1093/nar/gkac1033

Author

Kelleher, Keith J. ; Sheils, Timothy K. ; Mathias, Stephen L. ; Yang, Jeremy J. ; Metzger, Vincent T. ; Siramshetty, Vishal B. ; Nguyen, Dac-Trung ; Jensen, Lars Juhl ; Vidovic, Dusica ; Schurer, Stephan C. ; Holmes, Jayme ; Sharma, Karlie R. ; Pillai, Ajay ; Bologa, Cristian G. ; Edwards, Jeremy S. ; Mathe, Ewy A. ; Oprea, Tudor. / Pharos 2023 : an integrated resource for the understudied human proteome. In: Nucleic Acids Research. 2023 ; Vol. 51, No. D1. pp. D1405-D1416.

Bibtex

@article{f032f17bc49b4c109eb336e30874c00f,
title = "Pharos 2023: an integrated resource for the understudied human proteome",
abstract = "The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of disease biology by perturbing them with small molecules, biologics, or other therapeutic modalities. Two main products from the IDG effort are the Target Central Resource Database (TCRD), which curates and aggregates information, and Pharos, a web interface for fusers to extract and visualize data from TCRD. Since the 2021 release, TCRD/Pharos has focused on developing visualization and analysis tools that help reveal higher-level patterns in the underlying data. The current iterations of TCRD and Pharos enable users to perform enrichment calculations based on subsets of targets, diseases, or ligands and to create interactive heat maps and UpSet charts of many types of annotations. Using several examples, we show how to address disease biology and drug discovery questions through enrichment calculations and UpSet charts.",
keywords = "DATABASE, VISUALIZATION, DISCOVERY, ONTOLOGY, MAP",
author = "Kelleher, {Keith J.} and Sheils, {Timothy K.} and Mathias, {Stephen L.} and Yang, {Jeremy J.} and Metzger, {Vincent T.} and Siramshetty, {Vishal B.} and Dac-Trung Nguyen and Jensen, {Lars Juhl} and Dusica Vidovic and Schurer, {Stephan C.} and Jayme Holmes and Sharma, {Karlie R.} and Ajay Pillai and Bologa, {Cristian G.} and Edwards, {Jeremy S.} and Mathe, {Ewy A.} and Tudor Oprea",
year = "2023",
doi = "10.1093/nar/gkac1033",
language = "English",
volume = "51",
pages = "D1405--D1416",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "D1",

}

RIS

TY - JOUR

T1 - Pharos 2023

T2 - an integrated resource for the understudied human proteome

AU - Kelleher, Keith J.

AU - Sheils, Timothy K.

AU - Mathias, Stephen L.

AU - Yang, Jeremy J.

AU - Metzger, Vincent T.

AU - Siramshetty, Vishal B.

AU - Nguyen, Dac-Trung

AU - Jensen, Lars Juhl

AU - Vidovic, Dusica

AU - Schurer, Stephan C.

AU - Holmes, Jayme

AU - Sharma, Karlie R.

AU - Pillai, Ajay

AU - Bologa, Cristian G.

AU - Edwards, Jeremy S.

AU - Mathe, Ewy A.

AU - Oprea, Tudor

PY - 2023

Y1 - 2023

N2 - The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of disease biology by perturbing them with small molecules, biologics, or other therapeutic modalities. Two main products from the IDG effort are the Target Central Resource Database (TCRD), which curates and aggregates information, and Pharos, a web interface for fusers to extract and visualize data from TCRD. Since the 2021 release, TCRD/Pharos has focused on developing visualization and analysis tools that help reveal higher-level patterns in the underlying data. The current iterations of TCRD and Pharos enable users to perform enrichment calculations based on subsets of targets, diseases, or ligands and to create interactive heat maps and UpSet charts of many types of annotations. Using several examples, we show how to address disease biology and drug discovery questions through enrichment calculations and UpSet charts.

AB - The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of disease biology by perturbing them with small molecules, biologics, or other therapeutic modalities. Two main products from the IDG effort are the Target Central Resource Database (TCRD), which curates and aggregates information, and Pharos, a web interface for fusers to extract and visualize data from TCRD. Since the 2021 release, TCRD/Pharos has focused on developing visualization and analysis tools that help reveal higher-level patterns in the underlying data. The current iterations of TCRD and Pharos enable users to perform enrichment calculations based on subsets of targets, diseases, or ligands and to create interactive heat maps and UpSet charts of many types of annotations. Using several examples, we show how to address disease biology and drug discovery questions through enrichment calculations and UpSet charts.

KW - DATABASE

KW - VISUALIZATION

KW - DISCOVERY

KW - ONTOLOGY

KW - MAP

U2 - 10.1093/nar/gkac1033

DO - 10.1093/nar/gkac1033

M3 - Journal article

C2 - 36624666

VL - 51

SP - D1405-D1416

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - D1

M1 - gkac1033

ER -

ID: 330737800