Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People with HIV

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People with HIV. / Bundgård, Johanne; Jensen, Anne Marie R.; Suarez-Zdunek, Moises A.; Høgh, Julie; Gerstoft, Jan; Benfield, Thomas; Ostrowski, Sisse R.; Nielsen, Susanne D.; Knudsen, Andreas D.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 93, No. 3, 2023, p. 237-243.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bundgård, J, Jensen, AMR, Suarez-Zdunek, MA, Høgh, J, Gerstoft, J, Benfield, T, Ostrowski, SR, Nielsen, SD & Knudsen, AD 2023, 'Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People with HIV', Journal of Acquired Immune Deficiency Syndromes, vol. 93, no. 3, pp. 237-243. https://doi.org/10.1097/QAI.0000000000003194

APA

Bundgård, J., Jensen, A. M. R., Suarez-Zdunek, M. A., Høgh, J., Gerstoft, J., Benfield, T., Ostrowski, S. R., Nielsen, S. D., & Knudsen, A. D. (2023). Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People with HIV. Journal of Acquired Immune Deficiency Syndromes, 93(3), 237-243. https://doi.org/10.1097/QAI.0000000000003194

Vancouver

Bundgård J, Jensen AMR, Suarez-Zdunek MA, Høgh J, Gerstoft J, Benfield T et al. Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People with HIV. Journal of Acquired Immune Deficiency Syndromes. 2023;93(3):237-243. https://doi.org/10.1097/QAI.0000000000003194

Author

Bundgård, Johanne ; Jensen, Anne Marie R. ; Suarez-Zdunek, Moises A. ; Høgh, Julie ; Gerstoft, Jan ; Benfield, Thomas ; Ostrowski, Sisse R. ; Nielsen, Susanne D. ; Knudsen, Andreas D. / Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People with HIV. In: Journal of Acquired Immune Deficiency Syndromes. 2023 ; Vol. 93, No. 3. pp. 237-243.

Bibtex

@article{16e02678295243e5839542d07320e87a,

title = "Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People with HIV",

abstract = "Background:People with HIV (PWH) have an increased risk of peripheral artery disease (PAD), but the pathogenesis is unknown. We aimed to determine the associations between markers of endothelial dysfunction and platelet activation and both PAD at baseline and de novo PAD in PWH.Methods:In total, 1012 PWH from the longitudinal Copenhagen Comorbidity in HIV-infection (COCOMO) study and 57 age-matched and sex-matched population controls were included. Plasma samples were collected at baseline and analyzed for soluble thrombomodulin, syndecan-1, and CD40 ligand (sCD40L). The ankle-brachial index was measured at baseline and two-year follow-up in PWH. Logistic and Poisson regression models were used to test associations.Results:PWH had higher concentrations of soluble thrombomodulin (P = 0.03) and syndecan-1 (P < 0.001) and lower concentration of sCD40L (P < 0.001) compared with controls. High concentration of soluble thrombomodulin, but not syndecan-1 or sCD40L, was associated with lower odds of PAD in PWH at baseline after adjustments (adjusted odds ratio: 0.50 [0.28, 0.90], P = 0.02). None of the markers were associated with de novo PAD.Conclusions:PWH had higher concentrations of soluble thrombomodulin and syndecan-1 and lower concentration of sCD40L compared with controls. Soluble thrombomodulin was associated with lower odds of PAD at baseline. Further studies are needed to elucidate the pathogenesis of PAD in people with HIV.",

keywords = "endothelial dysfunction, human immunodeficiency virus (HIV), peripheral artery disease (PAD), soluble CD40 ligand (sCD40L), soluble syndecan-1 (sdc-1), soluble thrombomodulin (sTM)",

author = "Johanne Bundg{\aa}rd and Jensen, {Anne Marie R.} and Suarez-Zdunek, {Moises A.} and Julie H{\o}gh and Jan Gerstoft and Thomas Benfield and Ostrowski, {Sisse R.} and Nielsen, {Susanne D.} and Knudsen, {Andreas D.}",

year = "2023",

doi = "10.1097/QAI.0000000000003194",

language = "English",

volume = "93",

pages = "237--243",

journal = "J A I D S",

issn = "1525-4135",

publisher = "Lippincott Williams & Wilkins",

number = "3",

}

RIS

TY - JOUR

T1 - Peripheral Artery Disease and Markers of Endothelial Dysfunction and Platelet Activation in People with HIV

AU - Bundgård, Johanne

AU - Jensen, Anne Marie R.

AU - Suarez-Zdunek, Moises A.

AU - Høgh, Julie

AU - Gerstoft, Jan

AU - Benfield, Thomas

AU - Ostrowski, Sisse R.

AU - Nielsen, Susanne D.

AU - Knudsen, Andreas D.

PY - 2023

Y1 - 2023

N2 - Background:People with HIV (PWH) have an increased risk of peripheral artery disease (PAD), but the pathogenesis is unknown. We aimed to determine the associations between markers of endothelial dysfunction and platelet activation and both PAD at baseline and de novo PAD in PWH.Methods:In total, 1012 PWH from the longitudinal Copenhagen Comorbidity in HIV-infection (COCOMO) study and 57 age-matched and sex-matched population controls were included. Plasma samples were collected at baseline and analyzed for soluble thrombomodulin, syndecan-1, and CD40 ligand (sCD40L). The ankle-brachial index was measured at baseline and two-year follow-up in PWH. Logistic and Poisson regression models were used to test associations.Results:PWH had higher concentrations of soluble thrombomodulin (P = 0.03) and syndecan-1 (P < 0.001) and lower concentration of sCD40L (P < 0.001) compared with controls. High concentration of soluble thrombomodulin, but not syndecan-1 or sCD40L, was associated with lower odds of PAD in PWH at baseline after adjustments (adjusted odds ratio: 0.50 [0.28, 0.90], P = 0.02). None of the markers were associated with de novo PAD.Conclusions:PWH had higher concentrations of soluble thrombomodulin and syndecan-1 and lower concentration of sCD40L compared with controls. Soluble thrombomodulin was associated with lower odds of PAD at baseline. Further studies are needed to elucidate the pathogenesis of PAD in people with HIV.

AB - Background:People with HIV (PWH) have an increased risk of peripheral artery disease (PAD), but the pathogenesis is unknown. We aimed to determine the associations between markers of endothelial dysfunction and platelet activation and both PAD at baseline and de novo PAD in PWH.Methods:In total, 1012 PWH from the longitudinal Copenhagen Comorbidity in HIV-infection (COCOMO) study and 57 age-matched and sex-matched population controls were included. Plasma samples were collected at baseline and analyzed for soluble thrombomodulin, syndecan-1, and CD40 ligand (sCD40L). The ankle-brachial index was measured at baseline and two-year follow-up in PWH. Logistic and Poisson regression models were used to test associations.Results:PWH had higher concentrations of soluble thrombomodulin (P = 0.03) and syndecan-1 (P < 0.001) and lower concentration of sCD40L (P < 0.001) compared with controls. High concentration of soluble thrombomodulin, but not syndecan-1 or sCD40L, was associated with lower odds of PAD in PWH at baseline after adjustments (adjusted odds ratio: 0.50 [0.28, 0.90], P = 0.02). None of the markers were associated with de novo PAD.Conclusions:PWH had higher concentrations of soluble thrombomodulin and syndecan-1 and lower concentration of sCD40L compared with controls. Soluble thrombomodulin was associated with lower odds of PAD at baseline. Further studies are needed to elucidate the pathogenesis of PAD in people with HIV.

KW - endothelial dysfunction

KW - human immunodeficiency virus (HIV)

KW - peripheral artery disease (PAD)

KW - soluble CD40 ligand (sCD40L)

KW - soluble syndecan-1 (sdc-1)

KW - soluble thrombomodulin (sTM)

U2 - 10.1097/QAI.0000000000003194

DO - 10.1097/QAI.0000000000003194

M3 - Journal article

C2 - 36961943

AN - SCOPUS:85163192823

VL - 93

SP - 237

EP - 243

JO - J A I D S

JF - J A I D S

SN - 1525-4135

IS - 3

ER -

ID: 370663949