Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women. / Immanuel, Jincy; Simmons, David; Desoye, Gernot; Corcoy, Rosa; Adelantado, Juan M.; Devlieger, Roland; Lapolla, Annunziata; Dalfra, Maria G.; Bertolotto, Alessandra; Harreiter, Jürgen; Wender-Ozegowska, Ewa; Zawiejska, Agnieszka; Dunne, Fidelma P.; Damm, Peter; Mathiesen, Elisabeth R.; Jensen, Dorte M.; Andersen, Lise Lotte T.; Hill, David J.; Jelsma, Judith G.M.; Snoek, Frank J.; Scharnagl, Hubert; Galjaard, Sander; Kautzky-Willer, Alexandra; VAN Poppel, Mireille N.M.

In: Diabetes Research and Clinical Practice, Vol. 168, 108378, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Immanuel, J, Simmons, D, Desoye, G, Corcoy, R, Adelantado, JM, Devlieger, R, Lapolla, A, Dalfra, MG, Bertolotto, A, Harreiter, J, Wender-Ozegowska, E, Zawiejska, A, Dunne, FP, Damm, P, Mathiesen, ER, Jensen, DM, Andersen, LLT, Hill, DJ, Jelsma, JGM, Snoek, FJ, Scharnagl, H, Galjaard, S, Kautzky-Willer, A & VAN Poppel, MNM 2020, 'Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women', Diabetes Research and Clinical Practice, vol. 168, 108378. https://doi.org/10.1016/j.diabres.2020.108378

APA

Immanuel, J., Simmons, D., Desoye, G., Corcoy, R., Adelantado, J. M., Devlieger, R., Lapolla, A., Dalfra, M. G., Bertolotto, A., Harreiter, J., Wender-Ozegowska, E., Zawiejska, A., Dunne, F. P., Damm, P., Mathiesen, E. R., Jensen, D. M., Andersen, L. L. T., Hill, D. J., Jelsma, J. G. M., ... VAN Poppel, M. N. M. (2020). Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women. Diabetes Research and Clinical Practice, 168, [108378]. https://doi.org/10.1016/j.diabres.2020.108378

Vancouver

Immanuel J, Simmons D, Desoye G, Corcoy R, Adelantado JM, Devlieger R et al. Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women. Diabetes Research and Clinical Practice. 2020;168. 108378. https://doi.org/10.1016/j.diabres.2020.108378

Author

Immanuel, Jincy ; Simmons, David ; Desoye, Gernot ; Corcoy, Rosa ; Adelantado, Juan M. ; Devlieger, Roland ; Lapolla, Annunziata ; Dalfra, Maria G. ; Bertolotto, Alessandra ; Harreiter, Jürgen ; Wender-Ozegowska, Ewa ; Zawiejska, Agnieszka ; Dunne, Fidelma P. ; Damm, Peter ; Mathiesen, Elisabeth R. ; Jensen, Dorte M. ; Andersen, Lise Lotte T. ; Hill, David J. ; Jelsma, Judith G.M. ; Snoek, Frank J. ; Scharnagl, Hubert ; Galjaard, Sander ; Kautzky-Willer, Alexandra ; VAN Poppel, Mireille N.M. / Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women. In: Diabetes Research and Clinical Practice. 2020 ; Vol. 168.

Bibtex

@article{d299e4f613704e90b34260968bf46191,
title = "Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women",
abstract = "Aims: To investigate the performance of early pregnancy HbA1c for predicting gestational diabetes mellitus (GDM) and adverse pregnancy outcomes in obese women. Methods: Post hoc analysis using data from the Vitamin D And Lifestyle Intervention for GDM prevention trials conducted across 9 European countries (2012–2014). Pregnant women (BMI ≥ 29 kg/m2) underwent a baseline HbA1c and oral glucose tolerance tests at < 20 weeks, 24–28 weeks, and 35–37 weeks. Women with GDM were referred for treatment. Results: Among the 869 women tested, the prevalence of GDM was 25.9% before 20 weeks, with a further 8.6% at 24–28 weeks. The areas under the curves for HbA1c at the two time points were 0.55 (0.50–0.59) and 0.54 (0.47–0.61), respectively. An early HbA1c ≥ 5.7% (39 mmol/mol) (N = 111) showed low sensitivity (18.2%) with 89.1% specificity for GDM before 20 weeks, at 24–28 weeks (sensitivity of 8.0% and specificity of 88.6% after excluding early GDM), and throughout gestation (sensitivity of 15.9% and specificity of 89.4%). The ≥ 5.7% (39 mmol/mol) threshold was significantly associated with concurrent GDM before 20 weeks (adjusted OR (aOR) 2.77(1.39–5.51)) and throughout gestation (aOR 1.72 (1.02–2.89)), but not adverse pregnancy outcomes. Conclusions: Early pregnancy HbA1c is of limited use for predicting either GDM or adverse outcomes in overweight/obese European women.",
keywords = "Diagnostic threshold, Gestational diabetes mellitus, Hemoglobin A, Odds Ratio, Pregnancy, Pregnancy outcome",
author = "Jincy Immanuel and David Simmons and Gernot Desoye and Rosa Corcoy and Adelantado, {Juan M.} and Roland Devlieger and Annunziata Lapolla and Dalfra, {Maria G.} and Alessandra Bertolotto and J{\"u}rgen Harreiter and Ewa Wender-Ozegowska and Agnieszka Zawiejska and Dunne, {Fidelma P.} and Peter Damm and Mathiesen, {Elisabeth R.} and Jensen, {Dorte M.} and Andersen, {Lise Lotte T.} and Hill, {David J.} and Jelsma, {Judith G.M.} and Snoek, {Frank J.} and Hubert Scharnagl and Sander Galjaard and Alexandra Kautzky-Willer and {VAN Poppel}, {Mireille N.M.}",
year = "2020",
doi = "10.1016/j.diabres.2020.108378",
language = "English",
volume = "168",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women

AU - Immanuel, Jincy

AU - Simmons, David

AU - Desoye, Gernot

AU - Corcoy, Rosa

AU - Adelantado, Juan M.

AU - Devlieger, Roland

AU - Lapolla, Annunziata

AU - Dalfra, Maria G.

AU - Bertolotto, Alessandra

AU - Harreiter, Jürgen

AU - Wender-Ozegowska, Ewa

AU - Zawiejska, Agnieszka

AU - Dunne, Fidelma P.

AU - Damm, Peter

AU - Mathiesen, Elisabeth R.

AU - Jensen, Dorte M.

AU - Andersen, Lise Lotte T.

AU - Hill, David J.

AU - Jelsma, Judith G.M.

AU - Snoek, Frank J.

AU - Scharnagl, Hubert

AU - Galjaard, Sander

AU - Kautzky-Willer, Alexandra

AU - VAN Poppel, Mireille N.M.

PY - 2020

Y1 - 2020

N2 - Aims: To investigate the performance of early pregnancy HbA1c for predicting gestational diabetes mellitus (GDM) and adverse pregnancy outcomes in obese women. Methods: Post hoc analysis using data from the Vitamin D And Lifestyle Intervention for GDM prevention trials conducted across 9 European countries (2012–2014). Pregnant women (BMI ≥ 29 kg/m2) underwent a baseline HbA1c and oral glucose tolerance tests at < 20 weeks, 24–28 weeks, and 35–37 weeks. Women with GDM were referred for treatment. Results: Among the 869 women tested, the prevalence of GDM was 25.9% before 20 weeks, with a further 8.6% at 24–28 weeks. The areas under the curves for HbA1c at the two time points were 0.55 (0.50–0.59) and 0.54 (0.47–0.61), respectively. An early HbA1c ≥ 5.7% (39 mmol/mol) (N = 111) showed low sensitivity (18.2%) with 89.1% specificity for GDM before 20 weeks, at 24–28 weeks (sensitivity of 8.0% and specificity of 88.6% after excluding early GDM), and throughout gestation (sensitivity of 15.9% and specificity of 89.4%). The ≥ 5.7% (39 mmol/mol) threshold was significantly associated with concurrent GDM before 20 weeks (adjusted OR (aOR) 2.77(1.39–5.51)) and throughout gestation (aOR 1.72 (1.02–2.89)), but not adverse pregnancy outcomes. Conclusions: Early pregnancy HbA1c is of limited use for predicting either GDM or adverse outcomes in overweight/obese European women.

AB - Aims: To investigate the performance of early pregnancy HbA1c for predicting gestational diabetes mellitus (GDM) and adverse pregnancy outcomes in obese women. Methods: Post hoc analysis using data from the Vitamin D And Lifestyle Intervention for GDM prevention trials conducted across 9 European countries (2012–2014). Pregnant women (BMI ≥ 29 kg/m2) underwent a baseline HbA1c and oral glucose tolerance tests at < 20 weeks, 24–28 weeks, and 35–37 weeks. Women with GDM were referred for treatment. Results: Among the 869 women tested, the prevalence of GDM was 25.9% before 20 weeks, with a further 8.6% at 24–28 weeks. The areas under the curves for HbA1c at the two time points were 0.55 (0.50–0.59) and 0.54 (0.47–0.61), respectively. An early HbA1c ≥ 5.7% (39 mmol/mol) (N = 111) showed low sensitivity (18.2%) with 89.1% specificity for GDM before 20 weeks, at 24–28 weeks (sensitivity of 8.0% and specificity of 88.6% after excluding early GDM), and throughout gestation (sensitivity of 15.9% and specificity of 89.4%). The ≥ 5.7% (39 mmol/mol) threshold was significantly associated with concurrent GDM before 20 weeks (adjusted OR (aOR) 2.77(1.39–5.51)) and throughout gestation (aOR 1.72 (1.02–2.89)), but not adverse pregnancy outcomes. Conclusions: Early pregnancy HbA1c is of limited use for predicting either GDM or adverse outcomes in overweight/obese European women.

KW - Diagnostic threshold

KW - Gestational diabetes mellitus

KW - Hemoglobin A

KW - Odds Ratio

KW - Pregnancy

KW - Pregnancy outcome

U2 - 10.1016/j.diabres.2020.108378

DO - 10.1016/j.diabres.2020.108378

M3 - Journal article

C2 - 32828833

AN - SCOPUS:85090030724

VL - 168

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

M1 - 108378

ER -

ID: 250383457