Peptidoglycan and muropeptides from pathogens Agrobacterium and Xanthomonas elicit plant innate immunity: structure and activity

Research output: Contribution to journalJournal articlepeer-review

  • Gitte Erbs
  • Alba Silipo
  • Shazia Aslam
  • Cristina De Castro
  • Valeria Liparoti
  • Angela Flagiello
  • Pietro Pucci
  • Rosa Lanzetta
  • Michelangelo Parrilli
  • Antonio Molinaro
  • Newman, Mari-Anne
  • Richard M. Cooper
Peptidoglycan (PGN) is a unique and essential structural part of the bacterial cell wall. PGNs from two contrasting Gram-negative plant pathogenic bacteria elicited components characteristic of the innate immune system in Arabidopsis thaliana, such as transcription of the defense gene PR1, oxidative burst, medium alkalinization, and formation of callose. Highly purified muropeptides from PGNs were more effective elicitors of early defense responses than native PGN. Therefore, PGN and its constituents represent a Microbe-Associated Molecular Pattern (MAMP) in plant-bacterial interactions. PGN and muropeptides from aggressive Xanthomonas campestris pv. campestris were significantly more active than those from Agrobacterium tumefaciens, which must maintain host cell viability during infection. The structure of muropeptide components and the distinctive differences are described. Differing defense-eliciting abilities appear to depend on subtle structural differences in either carbohydrate or peptide groups.
Original languageEnglish
JournalChemistry & Biology
Issue number5
Pages (from-to)438-448
Number of pages11
Publication statusPublished - 2008

ID: 8112294