Parkinson disease and growth factors — is GDNF good enough?
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Parkinson disease and growth factors — is GDNF good enough? / Kirkeby, Agnete; Barker, Roger A.
In: Nature Reviews Neurology, Vol. 15, No. 6, 01.06.2019, p. 312-314.Research output: Contribution to journal › Comment/debate › Research › peer-review
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TY - JOUR
T1 - Parkinson disease and growth factors — is GDNF good enough?
AU - Kirkeby, Agnete
AU - Barker, Roger A.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Previous open-label trials testing glial cell line-derived neurotrophic factor (GDNF) family ligands in Parkinson disease have shown promising clinical effects. However, in placebo-controlled trials, the treatments have failed. A new randomized placebo-controlled trial of intraputamenal delivery of GDNF designed to resolve this conundrum has again failed to do just that.
AB - Previous open-label trials testing glial cell line-derived neurotrophic factor (GDNF) family ligands in Parkinson disease have shown promising clinical effects. However, in placebo-controlled trials, the treatments have failed. A new randomized placebo-controlled trial of intraputamenal delivery of GDNF designed to resolve this conundrum has again failed to do just that.
UR - http://www.scopus.com/inward/record.url?scp=85064011594&partnerID=8YFLogxK
U2 - 10.1038/s41582-019-0180-6
DO - 10.1038/s41582-019-0180-6
M3 - Comment/debate
C2 - 30948845
AN - SCOPUS:85064011594
VL - 15
SP - 312
EP - 314
JO - Nature Reviews. Neurology
JF - Nature Reviews. Neurology
SN - 1759-4758
IS - 6
ER -
ID: 228505366