Parental socioeconomic position and midlife allostatic load: a study of potential mediators
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Parental socioeconomic position and midlife allostatic load : a study of potential mediators. / Christensen, Dinne S; Flensborg-Madsen, Trine; Garde, Ellen; Hansen, Åse M; Pedersen, Jolene M; Mortensen, Erik L.
In: BMC Public Health, Vol. 18, No. 1, 1029, 2018.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Parental socioeconomic position and midlife allostatic load
T2 - a study of potential mediators
AU - Christensen, Dinne S
AU - Flensborg-Madsen, Trine
AU - Garde, Ellen
AU - Hansen, Åse M
AU - Pedersen, Jolene M
AU - Mortensen, Erik L
PY - 2018
Y1 - 2018
N2 - BACKGROUND: The mechanisms underlying the association of parental socioeconomic position with later life allostatic load remain unclear. The present study aims to examine potential pathways underlying this association: personality, social relations, intelligence and education.METHODS: The study comprised 361 members of the Copenhagen Perinatal Cohort who participated in two subsequent follow-ups: the Prenatal Development Project (mean age 27 years) and the Copenhagen Aging and Midlife Biobank study (mean age 50 years). Allostatic load was based on 14 biomarkers representing the inflammatory, metabolic and cardiovascular system measured at midlife. Information on potential mediators was collected in young adulthood, and their role in the association of parental socioeconomic position with midlife allostatic load were examined in linear regression path analyses.RESULTS: Parental socioeconomic position at one year was inversely associated with midlife allostatic load (β = - 0.238, p < .001). No mediation effects were found for personality or social relations. In a model including intelligence and education, a significant indirect effect was found for education (β = - 0.151, p < .001). A significant direct effect remained (β = - 0.111, p = .040).CONCLUSIONS: Parental socioeconomic position was inversely associated with allostatic load in midlife. Results suggest that part of this association was mediated by education. A better understanding of the non-cognitive pathways related to education is an important prerequisite for the development of effective intervention strategies.
AB - BACKGROUND: The mechanisms underlying the association of parental socioeconomic position with later life allostatic load remain unclear. The present study aims to examine potential pathways underlying this association: personality, social relations, intelligence and education.METHODS: The study comprised 361 members of the Copenhagen Perinatal Cohort who participated in two subsequent follow-ups: the Prenatal Development Project (mean age 27 years) and the Copenhagen Aging and Midlife Biobank study (mean age 50 years). Allostatic load was based on 14 biomarkers representing the inflammatory, metabolic and cardiovascular system measured at midlife. Information on potential mediators was collected in young adulthood, and their role in the association of parental socioeconomic position with midlife allostatic load were examined in linear regression path analyses.RESULTS: Parental socioeconomic position at one year was inversely associated with midlife allostatic load (β = - 0.238, p < .001). No mediation effects were found for personality or social relations. In a model including intelligence and education, a significant indirect effect was found for education (β = - 0.151, p < .001). A significant direct effect remained (β = - 0.111, p = .040).CONCLUSIONS: Parental socioeconomic position was inversely associated with allostatic load in midlife. Results suggest that part of this association was mediated by education. A better understanding of the non-cognitive pathways related to education is an important prerequisite for the development of effective intervention strategies.
KW - Allostasis
KW - Cohort Studies
KW - Educational Status
KW - Female
KW - Humans
KW - Intelligence
KW - Interpersonal Relations
KW - Linear Models
KW - Male
KW - Middle Aged
KW - Parents/psychology
KW - Personality
KW - Social Class
U2 - 10.1186/s12889-018-5956-x
DO - 10.1186/s12889-018-5956-x
M3 - Journal article
C2 - 30126406
VL - 18
JO - BMC Public Health
JF - BMC Public Health
SN - 1471-2458
IS - 1
M1 - 1029
ER -
ID: 203243192