Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives

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Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives. / Coello, Klara; Mäkinen, Ilari Jaakko Olavi; Kjærstad, Hanne Lie; Faurholt-Jepsen, Maria; Miskowiak, Kamilla Woznica; Poulsen, Henrik Enghusen; Vinberg, Maj; Kessing, Lars Vedel.

In: Translational Psychiatry, Vol. 14, No. 1, 81, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Coello, K, Mäkinen, IJO, Kjærstad, HL, Faurholt-Jepsen, M, Miskowiak, KW, Poulsen, HE, Vinberg, M & Kessing, LV 2024, 'Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives', Translational Psychiatry, vol. 14, no. 1, 81. https://doi.org/10.1038/s41398-024-02772-8

APA

Coello, K., Mäkinen, I. J. O., Kjærstad, H. L., Faurholt-Jepsen, M., Miskowiak, K. W., Poulsen, H. E., Vinberg, M., & Kessing, L. V. (2024). Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives. Translational Psychiatry, 14(1), [81]. https://doi.org/10.1038/s41398-024-02772-8

Vancouver

Coello K, Mäkinen IJO, Kjærstad HL, Faurholt-Jepsen M, Miskowiak KW, Poulsen HE et al. Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives. Translational Psychiatry. 2024;14(1). 81. https://doi.org/10.1038/s41398-024-02772-8

Author

Coello, Klara ; Mäkinen, Ilari Jaakko Olavi ; Kjærstad, Hanne Lie ; Faurholt-Jepsen, Maria ; Miskowiak, Kamilla Woznica ; Poulsen, Henrik Enghusen ; Vinberg, Maj ; Kessing, Lars Vedel. / Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives. In: Translational Psychiatry. 2024 ; Vol. 14, No. 1.

Bibtex

@article{c11704cfadb7460ab8ca4d01574aa430,

title = "Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives",

abstract = "Excessive oxidative stress-generated nucleoside damage seems to play a key role in bipolar disorder (BD) and may present a trait phenomenon associated with familial risk and is one of the putative mechanisms explaining accelerated atherosclerosis and premature cardiovascular diseases (CVD) in younger patients with BD. However, oxidative stress-generated nucleoside damage has not been studied in young BD patients and their unaffected relatives (UR). Therefore, we compared oxidative stress-generated damage to DNA and RNA in young patients newly diagnosed with BD, UR, and healthy control individuals (HC). Systemic oxidative stress-generated DNA and RNA damage levels were compared by analyzing urinary levels of 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-oxo-7,8-dihydroguanosine in participants aged 15–25 years, including 133 patients newly diagnosed with BD, 57 UR, and 83 HC. Compared with HC, damage to DNA was 21.8% higher in BD patients (B = 1.218, 95% CI = 1.111–1.335, p = <0.001) and 22.5% higher in UR (B = 1.225, 95% CI = 1.090–1.377, p = <0.002), while damage to RNA was 14.8% higher in BD patients (B = 1.148, 95% CI = 1.082–1.219, p = <0.001) and 14.0% higher in UR (B = 1.140, 95% CI = 1.055–1.230, p = < 0.001) in models adjusted for sex and age after correction for multiple comparison. Levels did not differ between patients with BD and UR. Our findings support higher oxidative stress-generated nucleoside damage being a trait phenomenon in BD associated with familial risk and highlight the importance of early diagnosis and treatment to prevent illness progression and development of premature CVD.",

author = "Klara Coello and M{\"a}kinen, {Ilari Jaakko Olavi} and Kj{\ae}rstad, {Hanne Lie} and Maria Faurholt-Jepsen and Miskowiak, {Kamilla Woznica} and Poulsen, {Henrik Enghusen} and Maj Vinberg and Kessing, {Lars Vedel}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

doi = "10.1038/s41398-024-02772-8",

language = "English",

volume = "14",

journal = "Translational Psychiatry",

issn = "2158-3188",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - Oxidation of DNA and RNA in young patients with newly diagnosed bipolar disorder and relatives

AU - Coello, Klara

AU - Mäkinen, Ilari Jaakko Olavi

AU - Kjærstad, Hanne Lie

AU - Faurholt-Jepsen, Maria

AU - Miskowiak, Kamilla Woznica

AU - Poulsen, Henrik Enghusen

AU - Vinberg, Maj

AU - Kessing, Lars Vedel

PY - 2024

Y1 - 2024

N2 - Excessive oxidative stress-generated nucleoside damage seems to play a key role in bipolar disorder (BD) and may present a trait phenomenon associated with familial risk and is one of the putative mechanisms explaining accelerated atherosclerosis and premature cardiovascular diseases (CVD) in younger patients with BD. However, oxidative stress-generated nucleoside damage has not been studied in young BD patients and their unaffected relatives (UR). Therefore, we compared oxidative stress-generated damage to DNA and RNA in young patients newly diagnosed with BD, UR, and healthy control individuals (HC). Systemic oxidative stress-generated DNA and RNA damage levels were compared by analyzing urinary levels of 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-oxo-7,8-dihydroguanosine in participants aged 15–25 years, including 133 patients newly diagnosed with BD, 57 UR, and 83 HC. Compared with HC, damage to DNA was 21.8% higher in BD patients (B = 1.218, 95% CI = 1.111–1.335, p = <0.001) and 22.5% higher in UR (B = 1.225, 95% CI = 1.090–1.377, p = <0.002), while damage to RNA was 14.8% higher in BD patients (B = 1.148, 95% CI = 1.082–1.219, p = <0.001) and 14.0% higher in UR (B = 1.140, 95% CI = 1.055–1.230, p = < 0.001) in models adjusted for sex and age after correction for multiple comparison. Levels did not differ between patients with BD and UR. Our findings support higher oxidative stress-generated nucleoside damage being a trait phenomenon in BD associated with familial risk and highlight the importance of early diagnosis and treatment to prevent illness progression and development of premature CVD.

AB - Excessive oxidative stress-generated nucleoside damage seems to play a key role in bipolar disorder (BD) and may present a trait phenomenon associated with familial risk and is one of the putative mechanisms explaining accelerated atherosclerosis and premature cardiovascular diseases (CVD) in younger patients with BD. However, oxidative stress-generated nucleoside damage has not been studied in young BD patients and their unaffected relatives (UR). Therefore, we compared oxidative stress-generated damage to DNA and RNA in young patients newly diagnosed with BD, UR, and healthy control individuals (HC). Systemic oxidative stress-generated DNA and RNA damage levels were compared by analyzing urinary levels of 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-oxo-7,8-dihydroguanosine in participants aged 15–25 years, including 133 patients newly diagnosed with BD, 57 UR, and 83 HC. Compared with HC, damage to DNA was 21.8% higher in BD patients (B = 1.218, 95% CI = 1.111–1.335, p = <0.001) and 22.5% higher in UR (B = 1.225, 95% CI = 1.090–1.377, p = <0.002), while damage to RNA was 14.8% higher in BD patients (B = 1.148, 95% CI = 1.082–1.219, p = <0.001) and 14.0% higher in UR (B = 1.140, 95% CI = 1.055–1.230, p = < 0.001) in models adjusted for sex and age after correction for multiple comparison. Levels did not differ between patients with BD and UR. Our findings support higher oxidative stress-generated nucleoside damage being a trait phenomenon in BD associated with familial risk and highlight the importance of early diagnosis and treatment to prevent illness progression and development of premature CVD.

U2 - 10.1038/s41398-024-02772-8

DO - 10.1038/s41398-024-02772-8

M3 - Journal article

C2 - 38331875

AN - SCOPUS:85184791013

VL - 14

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 1

M1 - 81

ER -

ID: 383703032