Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors

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Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors. / Ketabi, Zohreh; Bartuma, Katarina; Bernstein, Inge; Malander, Susanne; Grönberg, Henrik; Björck, Erik; Holck, Susanne; Nilbert, Mef; Ketabi, Zohreh; Ketabi, Zohreh.

In: Gynecologic Oncology, Vol. 121, No. 3, 06.2011.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ketabi, Z, Bartuma, K, Bernstein, I, Malander, S, Grönberg, H, Björck, E, Holck, S, Nilbert, M, Ketabi, Z & Ketabi, Z 2011, 'Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors', Gynecologic Oncology, vol. 121, no. 3. https://doi.org/10.1016/j.ygyno.2011.02.010, https://doi.org/10.1016/j.ygyno.2011.02.010

APA

Ketabi, Z., Bartuma, K., Bernstein, I., Malander, S., Grönberg, H., Björck, E., Holck, S., Nilbert, M., Ketabi, Z., & Ketabi, Z. (2011). Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors. Gynecologic Oncology, 121(3). https://doi.org/10.1016/j.ygyno.2011.02.010, https://doi.org/10.1016/j.ygyno.2011.02.010

Vancouver

Ketabi Z, Bartuma K, Bernstein I, Malander S, Grönberg H, Björck E et al. Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors. Gynecologic Oncology. 2011 Jun;121(3). https://doi.org/10.1016/j.ygyno.2011.02.010, https://doi.org/10.1016/j.ygyno.2011.02.010

Author

Ketabi, Zohreh ; Bartuma, Katarina ; Bernstein, Inge ; Malander, Susanne ; Grönberg, Henrik ; Björck, Erik ; Holck, Susanne ; Nilbert, Mef ; Ketabi, Zohreh ; Ketabi, Zohreh. / Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors. In: Gynecologic Oncology. 2011 ; Vol. 121, No. 3.

Bibtex

@article{8b8c35d340194bacbbcfa55a3d7dcdc6,

title = "Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors",

abstract = "OBJECTIVE: Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. METHODS: We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers identified in Swedish and Danish Lynch syndrome families. RESULTS: In total, 63 epithelial ovarian cancers developed at mean 48 (range 30-79) years of age with 47% being early stage (FIGO stage I). Histologically, endometrioid (35%) and clear cell (17%) tumors were overrepresented. The underlying MMR gene mutations in these families affected MSH2 in 49%, MSH6 in 33% and MLH1 in 17%. Immunohistochemical loss of the corresponding MMR protein was demonstrated in 33/36 (92%) tumors analyzed. CONCLUSION: The combined data from our cohorts demonstrate that ovarian cancer associated with Lynch syndrome typically presents at young age as early-stage, non-serous tumors, which implicates that a family history of colorectal and endometrial cancer should be specifically considered in such cases.",

author = "Zohreh Ketabi and Katarina Bartuma and Inge Bernstein and Susanne Malander and Henrik Gr{\"o}nberg and Erik Bj{\"o}rck and Susanne Holck and Mef Nilbert and Zohreh Ketabi and Zohreh Ketabi",

year = "2011",

month = jun,

doi = "10.1016/j.ygyno.2011.02.010",

language = "English",

volume = "121",

journal = "Gynecologic Oncology",

issn = "0090-8258",

publisher = "Academic Press",

number = "3",

}

RIS

TY - JOUR

T1 - Ovarian cancer linked to lynch syndrome typically presents as early-onset, non-serous epithelial tumors

AU - Ketabi, Zohreh

AU - Bartuma, Katarina

AU - Bernstein, Inge

AU - Malander, Susanne

AU - Grönberg, Henrik

AU - Björck, Erik

AU - Holck, Susanne

AU - Nilbert, Mef

AU - Ketabi, Zohreh

PY - 2011/6

Y1 - 2011/6

N2 - OBJECTIVE: Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. METHODS: We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers identified in Swedish and Danish Lynch syndrome families. RESULTS: In total, 63 epithelial ovarian cancers developed at mean 48 (range 30-79) years of age with 47% being early stage (FIGO stage I). Histologically, endometrioid (35%) and clear cell (17%) tumors were overrepresented. The underlying MMR gene mutations in these families affected MSH2 in 49%, MSH6 in 33% and MLH1 in 17%. Immunohistochemical loss of the corresponding MMR protein was demonstrated in 33/36 (92%) tumors analyzed. CONCLUSION: The combined data from our cohorts demonstrate that ovarian cancer associated with Lynch syndrome typically presents at young age as early-stage, non-serous tumors, which implicates that a family history of colorectal and endometrial cancer should be specifically considered in such cases.

AB - OBJECTIVE: Heredity is a major cause of ovarian cancer and during recent years the contribution from germline mismatch repair (MMR) gene mutations linked to Lynch syndrome has gradually been recognized. METHODS: We characterized clinical features, tumor morphology and mismatch repair defects in all ovarian cancers identified in Swedish and Danish Lynch syndrome families. RESULTS: In total, 63 epithelial ovarian cancers developed at mean 48 (range 30-79) years of age with 47% being early stage (FIGO stage I). Histologically, endometrioid (35%) and clear cell (17%) tumors were overrepresented. The underlying MMR gene mutations in these families affected MSH2 in 49%, MSH6 in 33% and MLH1 in 17%. Immunohistochemical loss of the corresponding MMR protein was demonstrated in 33/36 (92%) tumors analyzed. CONCLUSION: The combined data from our cohorts demonstrate that ovarian cancer associated with Lynch syndrome typically presents at young age as early-stage, non-serous tumors, which implicates that a family history of colorectal and endometrial cancer should be specifically considered in such cases.

U2 - 10.1016/j.ygyno.2011.02.010

DO - 10.1016/j.ygyno.2011.02.010

M3 - Journal article

C2 - 21388660

VL - 121

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 3

ER -

ID: 34071102