Outcomes following SARS-CoV-2 infection in individuals with and without solid organ transplantation — A Danish nationwide cohort study
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Outcomes following SARS-CoV-2 infection in individuals with and without solid organ transplantation — A Danish nationwide cohort study. / Overvad, Maria; Koch, Anders; Jespersen, Bente; Gustafsson, Finn; Krause, Tyra Grove; Hansen, Christian Holm; Ethelberg, Steen; Obel, Niels.
In: American Journal of Transplantation, Vol. 22, No. 11, 2022, p. 2627-2636.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Outcomes following SARS-CoV-2 infection in individuals with and without solid organ transplantation — A Danish nationwide cohort study
AU - Overvad, Maria
AU - Koch, Anders
AU - Jespersen, Bente
AU - Gustafsson, Finn
AU - Krause, Tyra Grove
AU - Hansen, Christian Holm
AU - Ethelberg, Steen
AU - Obel, Niels
N1 - Publisher Copyright: © 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.
PY - 2022
Y1 - 2022
N2 - The risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, hospitalization and death, and the effects of SARS-CoV-2 vaccines in solid organ transplant recipients (SOTRs) is still debated. We performed a nationwide, population-based, matched cohort study, including all Danish SOTRs (n = 5184) and a matched cohort from the general population (n = 41 472). Cox regression analyses were used to calculate incidence rate ratios (IRRs). SOTRs had a slightly increased risk of SARS-CoV-2 infection and were vaccinated earlier than the general population. The overall risk of hospital contact with COVID-19, severe COVID-19, need for assisted respiration, and hospitalization followed by death was substantially higher in SOTRs (IRR: 32.8 95%CI [29.0–37.0], 9.2 [6.7–12.7], 12.5 [7.6–20.8], 12.4 [7.9–12.7]). The risk of hospitalization and death after SARS-CoV-2 infection decreased substantially in SOTRs after the emergence of the Omicron variant (IRR: 0.45 [0.37–0.56], 0.17 [0.09–0.30]). Three vaccinations reduced the risk of SARS-CoV-2 infection only marginally compared to two vaccinations, but SOTRs with three vaccinations had a lower risk of death (IRR: 022 [0.16–0.35]). We conclude that SOTRs have a risk of SARS-CoV-2 infection comparable to the general population, but substantially increased the risk of hospitalization and death following SARS-CoV-2 infection. A third vaccination only reduces the risk of SARS-CoV2 infection marginally, but SOTRs vaccinated 3 times have reduced mortality.
AB - The risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, hospitalization and death, and the effects of SARS-CoV-2 vaccines in solid organ transplant recipients (SOTRs) is still debated. We performed a nationwide, population-based, matched cohort study, including all Danish SOTRs (n = 5184) and a matched cohort from the general population (n = 41 472). Cox regression analyses were used to calculate incidence rate ratios (IRRs). SOTRs had a slightly increased risk of SARS-CoV-2 infection and were vaccinated earlier than the general population. The overall risk of hospital contact with COVID-19, severe COVID-19, need for assisted respiration, and hospitalization followed by death was substantially higher in SOTRs (IRR: 32.8 95%CI [29.0–37.0], 9.2 [6.7–12.7], 12.5 [7.6–20.8], 12.4 [7.9–12.7]). The risk of hospitalization and death after SARS-CoV-2 infection decreased substantially in SOTRs after the emergence of the Omicron variant (IRR: 0.45 [0.37–0.56], 0.17 [0.09–0.30]). Three vaccinations reduced the risk of SARS-CoV-2 infection only marginally compared to two vaccinations, but SOTRs with three vaccinations had a lower risk of death (IRR: 022 [0.16–0.35]). We conclude that SOTRs have a risk of SARS-CoV-2 infection comparable to the general population, but substantially increased the risk of hospitalization and death following SARS-CoV-2 infection. A third vaccination only reduces the risk of SARS-CoV2 infection marginally, but SOTRs vaccinated 3 times have reduced mortality.
KW - clinical research/practice
KW - infection and infectious agents - viral
KW - infection and infectious agents – viral: SARS-CoV-2/COVID-19
KW - infectious disease
KW - solid organ transplantation
U2 - 10.1111/ajt.17142
DO - 10.1111/ajt.17142
M3 - Journal article
C2 - 35801493
AN - SCOPUS:85134622019
VL - 22
SP - 2627
EP - 2636
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 11
ER -
ID: 322652472