Outcome of peripheral T-cell lymphoma in first complete remission: a Danish-Swedish population-based study

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  • Henrik Cederleuf
  • Lasse Hjort Jakobsen
  • Fredrik Ellin
  • Brown, Peter de Nully
  • Thomas Stauffer Larsen
  • Martin Bøgsted
  • Thomas Relander
  • Mats Jerkeman
  • Tarec Christoffer El-Galaly

In the present study, we investigate the outcome of 109 Danish and 123 Swedish patients with nodal PTCL in first complete remission (CR), and examine the impact of imaging-based follow-up (FU) strategies. The patients were selected by the following criteria: (a) newly diagnosed nodal PTCL from 2007 to 2012, (b) age ≥18 years, and (c) CR after CHOP or CHOEP therapy. FU guidelines in Sweden included symptom assessment, clinical examinations and blood tests at 3–4-month intervals for 2 years. FU strategies in Denmark was similar but included routine imaging, usually every 6 months for 2 years. Patients had fully comparable characteristics. Overall survival (OS) estimates for patients in CR were similar for all patients (p =.6) and in PTCL subtypes. In multivariate analysis, country of follow-up had no impact on OS. However, despite continuous CR for ≥2 years, the OS of PTCL remained inferior to a matched general population.

Original languageEnglish
JournalLeukemia and Lymphoma
Issue number12
Pages (from-to)2815-2823
Number of pages9
Publication statusPublished - Dec 2017

    Research areas

  • Peripheral T-cell lymphoma, population based, routine imaging

ID: 188395327