On-chip electromembrane extraction for monitoring drug metabolism in real time by electrospray ionization mass spectrometry
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
Sample preparation is an essential step in any bioanalytical procedure and very often the most challenging step in method development. Most of the currently used methods require a relatively large amount of sample and are time consuming. Here, we describe a new approach based on electromembrane extraction (EME) integrated in microfluidic polymer chips. This procedure is fast, requires only small amounts of sample, and may thus be used for monitoring drug metabolism and the formation of metabolites in real time.
Original language | English |
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Title of host publication | Microchip Capillary Electrophoresis Protocols |
Editors | Ann Van Schepdael |
Number of pages | 12 |
Volume | 1274 |
Publisher | Humana Press |
Publication date | 2015 |
Pages | 171-82 |
Chapter | 15 |
ISBN (Print) | 978-1-4939-2352-6 |
ISBN (Electronic) | 978-1-4939-2353-3 |
DOIs | |
Publication status | Published - 2015 |
Series | Methods in molecular biology (Clifton, N.J.) |
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ID: 161364246