On the etiology of incident brain lacunes: longitudinal observations from the LADIS study
Research output: Contribution to journal › Journal article › Research › peer-review
BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes. CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region
Udgivelsesdato: 2008/11
Udgivelsesdato: 2008/11
Original language | English |
---|---|
Journal | Stroke |
Volume | 39 |
Issue number | 11 |
Pages (from-to) | 3083-3085 |
Number of pages | 2 |
ISSN | 0039-2499 |
Publication status | Published - 2008 |
ID: 14150626