TY - JOUR

T1 - Occupational variation in incidence of bladder cancer

T2 - a comparison of population-representative cohorts from Nordic countries and Canada

AU - Hadkhale, Kishor

AU - MacLeod, Jill

AU - Demers, Paul A.

AU - Martinsen, Jan Ivar

AU - Weiderpass, Elisabete

AU - Kjaerheim, Kristina

AU - Lynge, Elsebeth

AU - Sparen, Pär

AU - Tryggvadottir, Laufey

AU - Harris, M. Anne

AU - Tjepkema, Michael

AU - Peters, Paul A.

AU - Pukkala, Eero

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Objectives: The objective of this study was to compare occupational variation of the risk of bladder cancer in the Nordic countries and Canada.Methods: In the Nordic Occupational Cancer study (NOCCA), 73 653 bladder cancer cases were observed during follow-up of 141.6 million person-years. In the Canadian Census Health and Environment Cohort (CanCHEC), 8170 cases were observed during the follow-up of 36.7 million person-years. Standardised incidence ratios with 95% CI were estimated for 53 occupations in the NOCCA cohort and HR with 95% CIs were estimated for 42 occupations in the CanCHEC.Results: Elevated risks of bladder cancer were observed among hairdressers, printers, sales workers, plumbers, painters, miners and laundry workers. Teachers and agricultural workers had reduced risk of bladder cancer in both cohorts. Chimney-sweeps, tobacco workers and waiters had about 1.5-fold risk in the Nordic countries; no risk estimates for these categories were given from the CanCHEC cohort.Conclusion: We observed different occupational patterns in risk of bladder cancer in Nordic countries and Canada. The only occupation with similarly increased risk was observed among sales workers. Differences in smoking across occupational groups may explain some, but not all, of this variation.

AB - Objectives: The objective of this study was to compare occupational variation of the risk of bladder cancer in the Nordic countries and Canada.Methods: In the Nordic Occupational Cancer study (NOCCA), 73 653 bladder cancer cases were observed during follow-up of 141.6 million person-years. In the Canadian Census Health and Environment Cohort (CanCHEC), 8170 cases were observed during the follow-up of 36.7 million person-years. Standardised incidence ratios with 95% CI were estimated for 53 occupations in the NOCCA cohort and HR with 95% CIs were estimated for 42 occupations in the CanCHEC.Results: Elevated risks of bladder cancer were observed among hairdressers, printers, sales workers, plumbers, painters, miners and laundry workers. Teachers and agricultural workers had reduced risk of bladder cancer in both cohorts. Chimney-sweeps, tobacco workers and waiters had about 1.5-fold risk in the Nordic countries; no risk estimates for these categories were given from the CanCHEC cohort.Conclusion: We observed different occupational patterns in risk of bladder cancer in Nordic countries and Canada. The only occupation with similarly increased risk was observed among sales workers. Differences in smoking across occupational groups may explain some, but not all, of this variation.

U2 - 10.1136/bmjopen-2017-016538

DO - 10.1136/bmjopen-2017-016538

M3 - Journal article

C2 - 28780557

VL - 7

SP - 1

EP - 9

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 8

M1 - e016538

ER -