Ny markør ved trombotisk trombocytopenisk purpura.

Research output: Contribution to journalJournal articleResearchpeer-review

  • Gotze, Jens P.
  • Andreas Hillarp
  • Anders Lindblom
  • Peter Björk
  • Karin Strandberg
  • Lars Bo Nielsen
Thrombotic microangiopathy can be caused by several conditions which are difficult to diagnose from the clinical presentation alone. Deficient enzyme activity of a newly-discovered enzyme, ADAMTS-13, can lead to thrombotic thrombocytopenic purpura (TTP). Lack of ADAMTS-13 activity causes increased concentrations of high molecular weight von Willebrand factor forms and increased platelet aggregation. Measurement of ADAMTS-13 activity is useful for the diagnosis of TTP and may also be relevant as a prognostic test for recurrent TTP.
Udgivelsesdato: 2008-Aug-11
Original languageDanish
JournalUgeskrift for læger
Volume170
Issue number33
Pages (from-to)2446-9
Number of pages3
ISSN0041-5782
Publication statusPublished - 2008

Bibliographical note

Keywords: ADAM Proteins; Biological Markers; Diagnosis, Differential; Humans; Purpura, Thrombotic Thrombocytopenic; von Willebrand Factor

ID: 8466128