Notch 1 as a potential therapeutic target in cutaneous T-cell lymphoma

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Standard

Notch 1 as a potential therapeutic target in cutaneous T-cell lymphoma. / Kamstrup, Maria Rørbæk; Gjerdrum, Lise Mette Rahbek; Biskup, Edyta Urszula; Lauenborg, Britt Thyssing; Ralfkiær, Elisabeth Methner; Andersen, Anders Woetmann; Ødum, Niels; Gniadecki, Robert.

In: Blood, Vol. 116, No. 14, 07.01.2010, p. 2504-12.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kamstrup, MR, Gjerdrum, LMR, Biskup, EU, Lauenborg, BT, Ralfkiær, EM, Andersen, AW, Ødum, N & Gniadecki, R 2010, 'Notch 1 as a potential therapeutic target in cutaneous T-cell lymphoma', Blood, vol. 116, no. 14, pp. 2504-12. https://doi.org/10.1182/blood-2009-12-260216

APA

Kamstrup, M. R., Gjerdrum, L. M. R., Biskup, E. U., Lauenborg, B. T., Ralfkiær, E. M., Andersen, A. W., Ødum, N., & Gniadecki, R. (2010). Notch 1 as a potential therapeutic target in cutaneous T-cell lymphoma. Blood, 116(14), 2504-12. https://doi.org/10.1182/blood-2009-12-260216

Vancouver

Kamstrup MR, Gjerdrum LMR, Biskup EU, Lauenborg BT, Ralfkiær EM, Andersen AW et al. Notch 1 as a potential therapeutic target in cutaneous T-cell lymphoma. Blood. 2010 Jan 7;116(14):2504-12. https://doi.org/10.1182/blood-2009-12-260216

Author

Kamstrup, Maria Rørbæk ; Gjerdrum, Lise Mette Rahbek ; Biskup, Edyta Urszula ; Lauenborg, Britt Thyssing ; Ralfkiær, Elisabeth Methner ; Andersen, Anders Woetmann ; Ødum, Niels ; Gniadecki, Robert. / Notch 1 as a potential therapeutic target in cutaneous T-cell lymphoma. In: Blood. 2010 ; Vol. 116, No. 14. pp. 2504-12.

Bibtex

@article{338f5280c55f11df825b000ea68e967b,
title = "Notch 1 as a potential therapeutic target in cutaneous T-cell lymphoma",
abstract = "Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is unknown whether Notch signalling is involved in the pathogenesis of mycosis fungoides and Sezary syndrome, the most common subtypes of cutaneous T cell lymphoma. By immunohistochemistry of 40 biopsies taken from skin lesions of mycosis fungoides and Sezary syndrome we demonstrated prominent expression of Notch1 on tumor cells, especially in the more advanced stages. The gamma-secretase inhibitor I blocked Notch signaling and potently induced apoptosis in cell lines derived from mycosis fungoides (MyLa) and Sezary syndrome (SeAx, HuT-78)and in primary leukemic S{\'e}zary cells. Specific downregulation of Notch1 (but not Notch2 and Notch3) by siRNA induced apoptosis in SeAx. The mechanism of apoptosis involved the inhibition of NF-kappaB, which is the most important prosurvival pathway in cutaneous T cell lymphoma. Our data show that Notch is present in cutaneous T cell lymphoma and that its inhibition may provide a new way to treat cutaneous T cell lymphoma.",
author = "Kamstrup, {Maria R{\o}rb{\ae}k} and Gjerdrum, {Lise Mette Rahbek} and Biskup, {Edyta Urszula} and Lauenborg, {Britt Thyssing} and Ralfki{\ae}r, {Elisabeth Methner} and Andersen, {Anders Woetmann} and Niels {\O}dum and Robert Gniadecki",
year = "2010",
month = jan,
day = "7",
doi = "10.1182/blood-2009-12-260216",
language = "English",
volume = "116",
pages = "2504--12",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "14",

}

RIS

TY - JOUR

T1 - Notch 1 as a potential therapeutic target in cutaneous T-cell lymphoma

AU - Kamstrup, Maria Rørbæk

AU - Gjerdrum, Lise Mette Rahbek

AU - Biskup, Edyta Urszula

AU - Lauenborg, Britt Thyssing

AU - Ralfkiær, Elisabeth Methner

AU - Andersen, Anders Woetmann

AU - Ødum, Niels

AU - Gniadecki, Robert

PY - 2010/1/7

Y1 - 2010/1/7

N2 - Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is unknown whether Notch signalling is involved in the pathogenesis of mycosis fungoides and Sezary syndrome, the most common subtypes of cutaneous T cell lymphoma. By immunohistochemistry of 40 biopsies taken from skin lesions of mycosis fungoides and Sezary syndrome we demonstrated prominent expression of Notch1 on tumor cells, especially in the more advanced stages. The gamma-secretase inhibitor I blocked Notch signaling and potently induced apoptosis in cell lines derived from mycosis fungoides (MyLa) and Sezary syndrome (SeAx, HuT-78)and in primary leukemic Sézary cells. Specific downregulation of Notch1 (but not Notch2 and Notch3) by siRNA induced apoptosis in SeAx. The mechanism of apoptosis involved the inhibition of NF-kappaB, which is the most important prosurvival pathway in cutaneous T cell lymphoma. Our data show that Notch is present in cutaneous T cell lymphoma and that its inhibition may provide a new way to treat cutaneous T cell lymphoma.

AB - Deregulation of Notch signaling has been linked to the development of T-cell leukemias and several solid malignancies. Yet, it is unknown whether Notch signalling is involved in the pathogenesis of mycosis fungoides and Sezary syndrome, the most common subtypes of cutaneous T cell lymphoma. By immunohistochemistry of 40 biopsies taken from skin lesions of mycosis fungoides and Sezary syndrome we demonstrated prominent expression of Notch1 on tumor cells, especially in the more advanced stages. The gamma-secretase inhibitor I blocked Notch signaling and potently induced apoptosis in cell lines derived from mycosis fungoides (MyLa) and Sezary syndrome (SeAx, HuT-78)and in primary leukemic Sézary cells. Specific downregulation of Notch1 (but not Notch2 and Notch3) by siRNA induced apoptosis in SeAx. The mechanism of apoptosis involved the inhibition of NF-kappaB, which is the most important prosurvival pathway in cutaneous T cell lymphoma. Our data show that Notch is present in cutaneous T cell lymphoma and that its inhibition may provide a new way to treat cutaneous T cell lymphoma.

U2 - 10.1182/blood-2009-12-260216

DO - 10.1182/blood-2009-12-260216

M3 - Journal article

C2 - 20538790

VL - 116

SP - 2504

EP - 2512

JO - Blood

JF - Blood

SN - 0006-4971

IS - 14

ER -

ID: 22127101