Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference. / Foghsgaard, Signe; Andreasen, Camilla; Vedtofte, Louise; Andersen, Emilie S.; Bahne, Emilie; Strandberg, Charlotte; Buhl, Thora; Holst, Jens J; Svare, Jens A; Clausen, Tine D; Mathiesen, Elisabeth R; Damm, Peter; Gluud, Lise L; Knop, Filip K; Lauritsen, Tina Vilsbøll.

In: Diabetes Care, Vol. 40, No. 1, 01.2017, p. 109-116.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Foghsgaard, S, Andreasen, C, Vedtofte, L, Andersen, ES, Bahne, E, Strandberg, C, Buhl, T, Holst, JJ, Svare, JA, Clausen, TD, Mathiesen, ER, Damm, P, Gluud, LL, Knop, FK & Lauritsen, TV 2017, 'Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference', Diabetes Care, vol. 40, no. 1, pp. 109-116. https://doi.org/10.2337/dc16-1017

APA

Foghsgaard, S., Andreasen, C., Vedtofte, L., Andersen, E. S., Bahne, E., Strandberg, C., Buhl, T., Holst, J. J., Svare, J. A., Clausen, T. D., Mathiesen, E. R., Damm, P., Gluud, L. L., Knop, F. K., & Lauritsen, T. V. (2017). Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference. Diabetes Care, 40(1), 109-116. https://doi.org/10.2337/dc16-1017

Vancouver

Foghsgaard S, Andreasen C, Vedtofte L, Andersen ES, Bahne E, Strandberg C et al. Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference. Diabetes Care. 2017 Jan;40(1):109-116. https://doi.org/10.2337/dc16-1017

Author

Foghsgaard, Signe ; Andreasen, Camilla ; Vedtofte, Louise ; Andersen, Emilie S. ; Bahne, Emilie ; Strandberg, Charlotte ; Buhl, Thora ; Holst, Jens J ; Svare, Jens A ; Clausen, Tine D ; Mathiesen, Elisabeth R ; Damm, Peter ; Gluud, Lise L ; Knop, Filip K ; Lauritsen, Tina Vilsbøll. / Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference. In: Diabetes Care. 2017 ; Vol. 40, No. 1. pp. 109-116.

Bibtex

@article{0eedd88131334871a1e29500505b38e8,
title = "Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference",
abstract = "OBJECTIVE: Type 2 diabetes increases the risk of nonalcoholic fatty liver disease (NAFLD), which is a potentially reversible condition but is also associated with progressive fibrosis and cirrhosis. Women with prior gestational diabetes mellitus (pGDM) have a higher risk for NAFLD.RESEARCH DESIGN AND METHODS: One hundred women without diabetes who had pGDM (median [interquartile range]: age 38.6 [6.4] years; BMI 31.0 [6.2] kg/m(2)) and 11 healthy control subjects without NAFLD (age 37.9 [7.8] years; BMI 28.1 [0.8] kg/m(2)) underwent a 75-g oral glucose tolerance test (OGTT), DXA whole-body scan, and ultrasonic evaluation of hepatic steatosis.RESULTS: Twenty-four (24%) women with pGDM had NAFLD on the basis of the ultrasound scan. None had cirrhosis. Women with NAFLD had a higher BMI (P = 0.0002) and waist circumference (P = 0.0003), increased insulin resistance (P = 0.0004), and delayed suppression of glucagon after the OGTT (P < 0.0001), but NAFLD was not associated with the degree of glucose intolerance (P = 0.2196). Visceral fat mass differed among the three groups, with the NAFLD group having the highest amount of fat and the control subjects the lowest (P = 0.0003). By logistic regression analysis, insulin resistance (P = 0.0057) and waist circumference (P = 0.0109) were independently associated with NAFLD.CONCLUSIONS: NAFLD was prevalent in this cohort of relatively young and nonseverely obese women with pGDM who are considered healthy apart from their increased risk for diabetes. Insulin resistance and a larger waist circumference were independently associated with the presence of NAFLD, whereas glucose intolerance was not.",
author = "Signe Foghsgaard and Camilla Andreasen and Louise Vedtofte and Andersen, {Emilie S.} and Emilie Bahne and Charlotte Strandberg and Thora Buhl and Holst, {Jens J} and Svare, {Jens A} and Clausen, {Tine D} and Mathiesen, {Elisabeth R} and Peter Damm and Gluud, {Lise L} and Knop, {Filip K} and Lauritsen, {Tina Vilsb{\o}ll}",
note = "{\textcopyright} 2017 by the American Diabetes Association.",
year = "2017",
month = jan,
doi = "10.2337/dc16-1017",
language = "English",
volume = "40",
pages = "109--116",
journal = "Diabetes Care",
issn = "0149-5992",
publisher = "American Diabetes Association",
number = "1",

}

RIS

TY - JOUR

T1 - Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference

AU - Foghsgaard, Signe

AU - Andreasen, Camilla

AU - Vedtofte, Louise

AU - Andersen, Emilie S.

AU - Bahne, Emilie

AU - Strandberg, Charlotte

AU - Buhl, Thora

AU - Holst, Jens J

AU - Svare, Jens A

AU - Clausen, Tine D

AU - Mathiesen, Elisabeth R

AU - Damm, Peter

AU - Gluud, Lise L

AU - Knop, Filip K

AU - Lauritsen, Tina Vilsbøll

N1 - © 2017 by the American Diabetes Association.

PY - 2017/1

Y1 - 2017/1

N2 - OBJECTIVE: Type 2 diabetes increases the risk of nonalcoholic fatty liver disease (NAFLD), which is a potentially reversible condition but is also associated with progressive fibrosis and cirrhosis. Women with prior gestational diabetes mellitus (pGDM) have a higher risk for NAFLD.RESEARCH DESIGN AND METHODS: One hundred women without diabetes who had pGDM (median [interquartile range]: age 38.6 [6.4] years; BMI 31.0 [6.2] kg/m(2)) and 11 healthy control subjects without NAFLD (age 37.9 [7.8] years; BMI 28.1 [0.8] kg/m(2)) underwent a 75-g oral glucose tolerance test (OGTT), DXA whole-body scan, and ultrasonic evaluation of hepatic steatosis.RESULTS: Twenty-four (24%) women with pGDM had NAFLD on the basis of the ultrasound scan. None had cirrhosis. Women with NAFLD had a higher BMI (P = 0.0002) and waist circumference (P = 0.0003), increased insulin resistance (P = 0.0004), and delayed suppression of glucagon after the OGTT (P < 0.0001), but NAFLD was not associated with the degree of glucose intolerance (P = 0.2196). Visceral fat mass differed among the three groups, with the NAFLD group having the highest amount of fat and the control subjects the lowest (P = 0.0003). By logistic regression analysis, insulin resistance (P = 0.0057) and waist circumference (P = 0.0109) were independently associated with NAFLD.CONCLUSIONS: NAFLD was prevalent in this cohort of relatively young and nonseverely obese women with pGDM who are considered healthy apart from their increased risk for diabetes. Insulin resistance and a larger waist circumference were independently associated with the presence of NAFLD, whereas glucose intolerance was not.

AB - OBJECTIVE: Type 2 diabetes increases the risk of nonalcoholic fatty liver disease (NAFLD), which is a potentially reversible condition but is also associated with progressive fibrosis and cirrhosis. Women with prior gestational diabetes mellitus (pGDM) have a higher risk for NAFLD.RESEARCH DESIGN AND METHODS: One hundred women without diabetes who had pGDM (median [interquartile range]: age 38.6 [6.4] years; BMI 31.0 [6.2] kg/m(2)) and 11 healthy control subjects without NAFLD (age 37.9 [7.8] years; BMI 28.1 [0.8] kg/m(2)) underwent a 75-g oral glucose tolerance test (OGTT), DXA whole-body scan, and ultrasonic evaluation of hepatic steatosis.RESULTS: Twenty-four (24%) women with pGDM had NAFLD on the basis of the ultrasound scan. None had cirrhosis. Women with NAFLD had a higher BMI (P = 0.0002) and waist circumference (P = 0.0003), increased insulin resistance (P = 0.0004), and delayed suppression of glucagon after the OGTT (P < 0.0001), but NAFLD was not associated with the degree of glucose intolerance (P = 0.2196). Visceral fat mass differed among the three groups, with the NAFLD group having the highest amount of fat and the control subjects the lowest (P = 0.0003). By logistic regression analysis, insulin resistance (P = 0.0057) and waist circumference (P = 0.0109) were independently associated with NAFLD.CONCLUSIONS: NAFLD was prevalent in this cohort of relatively young and nonseverely obese women with pGDM who are considered healthy apart from their increased risk for diabetes. Insulin resistance and a larger waist circumference were independently associated with the presence of NAFLD, whereas glucose intolerance was not.

U2 - 10.2337/dc16-1017

DO - 10.2337/dc16-1017

M3 - Journal article

C2 - 27810989

VL - 40

SP - 109

EP - 116

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 1

ER -

ID: 172765793